A5029360157- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Advanced Nanomaterials in Catalysis
- Photoacoustic and Ultrasonic Imaging
- Extracellular vesicles in disease
- Lung Cancer Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Inflammatory Biomarkers in Disease Prognosis
- Photodynamic Therapy Research Studies
- Epigenetics and DNA Methylation
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Advanced biosensing and bioanalysis techniques
- Colorectal Cancer Treatments and Studies
- Cancer-related gene regulation
- Ferroptosis and cancer prognosis
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Luminescence and Fluorescent Materials
- Histone Deacetylase Inhibitors Research
Shenzhen University
2018-2025
Yantai Institute of Coastal Zone Research
2024-2025
University of Chinese Academy of Sciences
2025
Fudan University Shanghai Cancer Center
2022-2024
Shanghai Medical College of Fudan University
2022-2024
Jiangxi Provincial People's Hospital
2024
Shenzhen University Health Science Center
2019-2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2024
Glucose oxidase (GOx) has been recognized as a "star" enzyme catalyst involved in cancer treatment the past few years. Herein, GOx is mineralized with manganese-doped calcium phosphate (MnCaP) to form spherical nanoparticles (GOx-MnCaP NPs) by an situ biomimetic mineralization method, followed loading of doxorubicin (DOX) construct biodegradable, biocompatible, and tumor acidity-responsive nanotheranostics for magnetic resonance imaging (MRI) cascade reaction-enhanced cooperative treatment....
Colitis-associated colorectal cancer (CAC), in which chronic inflammation is a well-recognized carcinogen, requires concurrent anti-inflammation and antitumor treatments the clinic. Herein, we report polyethylene glycol (PEG)-coated (PEGylated) ultrasmall rhodium nanodots (Rh-PEG NDs) can serve as metallic nanozyme with reactive oxygen nitrogen species (RONS) scavenging properties well photothermal activities for theranostics colon diseases. Benefiting from multienzyme against RONS, Rh-PEG...
Companion diagnostics (CDx) provides critical information for precision medicine. However, current CDx is mostly limited to in vitro tests, which cannot accurately evaluate the disease progression and treatment response real time. To overcome this challenge, herein a glucose oxidase (GOx)-engineered conjugated polymer (polyaniline, PANI) nanoplatform (denoted as PANITG) reported activatable imaging-based multistage augmented photothermal/starvation synergistic therapy. PANITG comprises...
Abstract The development of semiconducting polymers (SPs) with simultaneous second near‐infrared (NIR‐II) absorption and multimodal phototheranostic functions is highly desired in the field oncotherapy. Aggregation‐induced emission luminogens (AIEgens) have been acknowledged to possess unique potential integrating multiple diagnostic therapeutic modalities into one organic molecule. Nevertheless, SPs are hard achieve AIE activity due their extended π‐conjugated skeletons as well large planar...
To design a clinically translatable nanomedicine for photodynamic theranostics, the ingredients should be carefully considered. A high content of nanocarriers may cause extra toxicity in metabolism, and multiple theranostic agents would complicate preparation process. These issues less concern if nanocarrier itself has most functions. In this work, poly(ethylene glycol)-boron dipyrromethene amphiphile (PEG-F54 -BODIPY) with 54 fluorine-19 (19 F) is synthesized employed to emulsify...
Inspired by the chain reactions among silver nanoparticles, glucose oxidase (GOx) and intratumoral glucose, a degradable silver-based nanoplatform was developed for synergistic cancer starving-like/metal ion therapy.
Abstract Tumor‐microenvironment‐responsive theranostics have great potential for precision diagnosis and effective treatment of cancer. Polyaniline (PANI) is the first reported pH‐responsive organic photothermal agent widely used as a theranostic agent. However, tumor PANI‐based agents are not explored, mainly because conversion from emeraldine base (EB) to salt (ES) state PANI requires pH < 4, which lower than acidic microenvironment. Herein, designed prepared amplified photoacoustic...
Carbapenem-resistant organisms (CRO) have emerged as a significant worldwide issue. However, the availability of efficacious antibiotics for treating CRO infections remains limited. Polymyxins, including colistin sulfate, represent last-line therapeutic option against infections. This study aims to retrospectively evaluate clinical effectiveness and safety sulfate in managing among patients with hematological diseases. Between April 2022 January 2023, total 118 diagnosed infection were...
Alkaline phosphatase (ALP) is distributed widely in living organisms and an important biomarker closely related to many physiological pathological processes. However, vivo real-time detection of ALP remains a significant challenge. Herein, we developed turn-on molecular probe (denoted as LET-3) visualize activity tumor tissues through near-infrared fluorescence (NIRF) photoacoustic (PA) dual-modal imaging. LET-3, composed NIR hemicyanine dye (LET-CyOH) phosphate moiety, showed 23-fold NIRF...
Abstract The delivery of glucose oxidase (GOx) requires extra carriers, which suffers from early leakage and exposure GOx. These issues will be less concern if GOx itself acts as a drug carrier. However, the catalytic activity in blood still needs to inhibited. Herein, we found that could self‐assemble with hydrophobic molecules into uniform stable nanoparticles (NPs), including sorafenib, 4′‐(amino‐methyl phenyl)‐2,2′ : 6′,2′′‐terpyridine modified cyanin paclitaxel. NPs was significantly...
Biopsy samples were taken from the gastric mucosa of 209 patients endoscoped for dyspepsia symptoms. Campylobacter-like organisms (CLOs) cultured 74 179 (41.4%) cases and seen in sections 110 (52.6%) smears 119 (56.9%) cases; totally, 145 positive, giving a rate 69.4%. CLOs positive 45 57 (78.9%) with superficial gastritis, 52 64 (81.3%) atrophic 18 21 (85.7%) ulcer, 12 14 duodenal 8 10 (80.0%) stump whereas only few found 3 15 (20.0%) histologically normal subjects 7 28 (25.0%) carcinoma....
Annexin A3 (ANXA3) has been found to play important roles in cancer progression, metastasis, and drug resistance; however, its role hepatocellular carcinoma (HCC) remains unknown. In this study, we investigated the expression level, clinical significance biologic function of ANXA3 HCC. Real-time quantitative reverse transcriptase-polymerase chain reaction, western blotting immunohistochemical staining were used examine levels HCC tumor tissue, correlation with clinicopathological features...
Abstract Afatinib, a second-generation tyrosine kinase inhibitor (TKI), has been approved for the treatment of advanced EGFR -mutant non-small cell lung cancer (NSCLC). However, afatinib’s clinical application is still hampered by acquired resistance. Recently, autophagy considered as an important mechanism resistance to TKI. Herein, we investigated induction well its influence on anti-lung adenocarcinoma activity afatinib in two activating -mutants H1975 and H1650 cells. First, Growth...