A5015202222- Topological Materials and Phenomena
- Ferroptosis and cancer prognosis
- 2D Materials and Applications
- Perovskite Materials and Applications
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Adversarial Robustness in Machine Learning
- RNA modifications and cancer
- Advanced Condensed Matter Physics
- Thyroid Cancer Diagnosis and Treatment
- Reinforcement Learning in Robotics
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Bioinformatics and Genomic Networks
- Advanced Photocatalysis Techniques
- Quantum, superfluid, helium dynamics
- Electronic and Structural Properties of Oxides
- Quantum Dots Synthesis And Properties
- Gut microbiota and health
- Immune cells in cancer
- Recycling and Waste Management Techniques
- AI in cancer detection
- Extracellular vesicles in disease
- Municipal Solid Waste Management
- Nanocomposite Films for Food Packaging
Zhejiang University
2008-2025
Chinese Academy of Sciences
2022-2025
Tianjin Medical University Cancer Institute and Hospital
2015-2025
First Hospital of Lanzhou University
2025
Lanzhou University
2025
Huazhong University of Science and Technology
2019-2025
Photonics (United States)
2025
Shanghai Synchrotron Radiation Facility
2025
Shanghai Advanced Research Institute
2024-2025
Sichuan University
2019-2024
Immune checkpoint blockade (ICB) therapies have revolutionized the treatment of human cancers including lung adenocarcinoma (LUAD).However, our understanding immune subtyping LUAD and its association with clinical response inhibitor remains incomplete.Here we performed molecular analysis from Cancer Genome Atlas (TCGA) validated findings TCGA cohort in 9 independent validation cohorts.We conducted consensus nonnegative matrix factorization (NMF).Potential ICB therapy was estimated Tumor...
Abstract Cancer of unknown primary (CUP) site poses diagnostic challenges due to its elusive nature. Many cases CUP manifest as pleural and peritoneal serous effusions. Leveraging cytological images from 57,220 at four tertiary hospitals, we developed a deep-learning method for tumor origin differentiation using histology (TORCH) that can identify malignancy predict in both hydrothorax ascites. We examined performance on three internal ( n = 12,799) two external 14,538) testing sets. In...
The representative waste television recycling process was chosen as the object of this study, including manual dismantling and mechanical separation printed circuit boards (PCBs) cathode ray tubes (CRTs) in two independent workshops. During these processes, fine particulate matter heavy metals will be released into air to impact environment health workers. mass concentrations PM2.5 (particles below 2.5 μm diameter) workshops ranged from 252.6 290.8 μg/m(3) 112.7 169.4 μg/m(3), respectively....
Scissoring in thick bars suppresses buckling behavior serpentine traces that have thicknesses greater than their widths, as detailed a systematic set of analytical and experimental studies. copper enables elastic stretchability large ≈350%, corresponding to sixfold improvement over previously reported values for thin geometries (≈60%). As service our authors readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized...
Inspired by the chain reactions among silver nanoparticles, glucose oxidase (GOx) and intratumoral glucose, a degradable silver-based nanoplatform was developed for synergistic cancer starving-like/metal ion therapy.
// Shuai Zhen 1, 2 , Yoichiro Takahashi 3 Shunichi Narita Yi-Chen Yang 4 Xu Li 1 Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, P.R. China Key Laboratory Tumor Precision Medicine Shaanxi Province, iPS Cell Research and Application (CiRA), Kyoto Kyoto, Japan Tsinghua School Life Sciences, Beijing, Correspondence to: Li, email: lixu56@mail.xjtu.edu.cn Keywords: CRISPR/Cas9 delivery, aptamer-liposome chimera, prostate cancer,...
The accurate detection of glucose at cellular level remains a big challenge. In this study, signal amplification strategy mediated by silver nanocube (AgNC), oxidase (GOx), and ion fluorescence probe (denoted as AgNC-GOx/Ag+-FP) is proposed for amplified intracellular detection. AgNC oxidized into Ag+ H2O2 generated from GOx-catalyzed oxidation reaction, remarkably enhances the red Ag+-FP. Our results show that AgNC-GOx/Ag+-FP highly sensitive specific to H2O2. Afterward, feasibility using...
Abstract Colonoscopy is commonly used to screen for colorectal cancer (CRC). We develop a deep learning model called CRCNet optical diagnosis of CRC by training on 464,105 images from 12,179 patients and test its performance 2263 three independent datasets. At the patient-level, achieves an area under precision-recall curve (AUPRC) 0.882 (95% CI: 0.828–0.931), 0.874 (0.820–0.926) 0.867 (0.795–0.923). exceeds average endoscopists recall rate across two sets (91.3% versus 83.8%; two-sided...
Acral melanoma is a dismal subtype of occurring in glabrous acral skin, and has higher incidence East Asians. We perform single-cell RNA sequencing for 63,394 cells obtained from 5 3 cutaneous samples to investigate tumor heterogeneity immune environment. define orthogonal functional cell clusters that are involved TGF-beta signaling, Type I interferon, Wnt Cell cycle, Cholesterol efflux signaling. Signatures enriched TGF-beta, cholesterol signaling significantly associated with good...
Kagome superconductors AV3Sb5 (A = K, Rb, Cs) provide a fertile playground for studying intriguing phenomena, including nontrivial band topology, superconductivity, giant anomalous Hall effect, and charge density wave (CDW). Recently, C2 symmetric nematic phase prior to the superconducting state in drew enormous attention due its potential inheritance of symmetry unusual superconductivity. However, direct evidence rotation breaking electronic structure CDW from reciprocal space is still...
Exponential accumulation of single-cell transcriptomes poses great challenge for efficient assimilation. Here, we present an approach entitled generative pretraining from (tGPT) learning feature representation transcriptomes. tGPT is conceptually simple in that it autoregressive models the ranking a gene context its preceding neighbors. We developed with 22.3 million and used four datasets to evalutate performance on analysis tasks. In addition, examine applications bulk tissues. The...
Abstract Colorectal cancer is the third most common worldwide and there has been a concerning increase in incidence rate of colorectal among individuals under age 50. This study compared survival outcome between early-onset late-onset metastatic to find differences identify their prognostic factors. We obtained patient data from SEER database. Survival was estimated using Kaplan–Meier curves log-rank test. Univariate multivariate analyses were conducted utilizing COX models independent A...
Content-based video search reranking can be regarded as a process that uses visual content to recover the "true" ranking list from noisy one generated based on textual information. This paper explicitly formulates this problem in Bayesian framework, i.e., maximizing score consistency among visually similar shots while minimizing distance, which represents disagreement between objective and initial text-based. Different existing point-wise distance measures, compute terms of individual...
The crush-pneumatic separation-corona electrostatic separation production line provides a feasible method for industrialization of waste printed circuit boards (PCBs) recycling. To determine the potential environmental contamination in automatic workshop, noise and heavy metals (Cr, Cu, Cd, Pb) ambience have been evaluated this paper. mean level workshop has reduced from 96.4 to 79.3 dB since engineering control measures were employed. Noise whose frequency ranged 500 1000 Hz is controlled...
Lung cancer is one of the most common in cancer-related deaths worldwide, which characterized by its strong metastatic potential. The melatonin hormone secreted pineal grand has an antioxidant effect and protects cells against carcinogenic substances. However, effects lung stemness are largely unknown. We found that reduces CD133 expression ~50% cell lines, while results a sphere formation assay showed inhibits stemness. These were reversed when lines incubated with phospholipase C (PLC),...
Abstract Background tRNA-derived small noncoding RNAs (sncRNAs) are mainly categorized into tRNA halves (tiRNAs) and fragments (tRFs). Biological functions of tiRNAs in human solid tumor attracting more attention, but researches concerning the mechanisms tiRNAs-mediated tumorigenesis rarely. The direct regulatory relationship between splicing-related proteins remain elusive. Methods Papillary thyroid carcinoma (PTC) associated were screened by deep sequencing validated qRT-PCR Northern Blot...
Adversarial training is the most empirically successful approach in improving robustness of deep neural networks for image classification. For text classification, however, existing synonym substitution based adversarial attacks are effective but not very efficient to be incorporated into practical training. Gradient-based attacks, which images, hard implemented due lexical, grammatical and semantic constraints discrete input space. Thereby, we propose a fast attack method called Fast...
Abstract MicroRNAs (miRNAs) are involved in the progression of many cancers through largely unelucidated mechanisms. The results our present study identified a gene cluster, miR‐221/222, that is constitutively upregulated serum exosome samples patients with colorectal carcinoma (CRC) liver metastasis (LM); this upregulation predicts poor overall survival rate. Using an vitro cell coculture model, we demonstrated CRC exosomes harboring miR‐221/222 activate hepatocyte growth factor (HGF) by...
Hashimoto's thyroiditis (HT) is the main cause of hypothyroidism. We develop a deep learning model called HTNet for diagnosis HT by training on 106,513 thyroid ultrasound images from 17,934 patients and test its performance 5051 2 datasets static 1 dataset video data. achieves an area under receiver operating curve (AUC) 0.905 (95% CI: 0.894 to 0.915), 0.888 (0.836-0.939) 0.895 (0.862-0.927). exceeds radiologists' accuracy (83.2% versus 79.8%; binomial test, p < 0.001) sensitivity (82.6%...