A5066026439- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Colorectal and Anal Carcinomas
- Cardiac tumors and thrombi
- 3D Shape Modeling and Analysis
- Angiogenesis and VEGF in Cancer
- CAR-T cell therapy research
- Surgical site infection prevention
- 3D Surveying and Cultural Heritage
- Cutaneous Melanoma Detection and Management
- Cutaneous lymphoproliferative disorders research
- Soft tissue tumor case studies
- Cancer Immunotherapy and Biomarkers
- Tumors and Oncological Cases
- Optical Systems and Laser Technology
- Lymphoma Diagnosis and Treatment
- Remote Sensing and LiDAR Applications
- Metastasis and carcinoma case studies
- Soft tissue tumors and treatment
- Cancer-related molecular mechanisms research
- Bone Tumor Diagnosis and Treatments
- Cancer-related gene regulation
- Advanced Measurement and Metrology Techniques
- Ubiquitin and proteasome pathways
- Estrogen and related hormone effects
Tianjin Medical University Cancer Institute and Hospital
2014-2025
Tsinghua University
2024-2025
Heilongjiang University of Chinese Medicine
2024
Tsinghua–Berkeley Shenzhen Institute
2024
National Clinical Research
2020
South China Agricultural University
2015
Jiangnan University
2013
Tianjin Medical University
2012-2013
Zhongnan Hospital of Wuhan University
2008
Wuhan University
2008
Acral melanoma is a dismal subtype of occurring in glabrous acral skin, and has higher incidence East Asians. We perform single-cell RNA sequencing for 63,394 cells obtained from 5 3 cutaneous samples to investigate tumor heterogeneity immune environment. define orthogonal functional cell clusters that are involved TGF-beta signaling, Type I interferon, Wnt Cell cycle, Cholesterol efflux signaling. Signatures enriched TGF-beta, cholesterol signaling significantly associated with good...
Abstract Purpose: We aimed to investigate the efficacy and safety of anlotinib as adjuvant targeted therapy for completely resected localized high-grade soft-tissue sarcomas (STS). Patients Methods: with STS after complete resection were randomly assigned in a 1:1 ratio receive either oral 12 mg or placebo once daily on days 1 14 every 21 cycle, up six cycles until disease relapse, unmanageable toxicity, death. The analyzed. This trial was first exploring (NCT03951571). Results: Between June...
// Feng Li 1,2 , Zhichao Liao Jun Zhao Gang 2,3 Xubin 2,4 Xiaoling Du 5 Yun Yang and Jilong 1 Department of Bone Soft Tissue Tumor, Tianjin Medical University Cancer Institute & Hospital, Tianjin, People's Republic China 2 National Clinical Research Center Cancer, 3 Pathology, 4 Radiology, Diagnostics, University, Correspondence to: Yang, email: Keywords : sarcoma; Apatinib; efficacy; progression free survival; clinical benefit response Received October 06, 2016 Accepted March 01, 2017...
As the most aggressive type of skin cancer, melanoma seriously affects human health. Long noncoding (lncRNA) 19 has been demonstrated to be involved in progression a number different types cancers. However, involvement lncRNA H19 remains unknown. Therefore, present study was performed investigate roles development and melanoma. In study, 49 patients with were included. Expression tumor tissue, adjacent healthy tissue various cell lines treatments measured by reverse...
Apatinib (YN968D1) is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR-2). We conducted single-arm, nonrandomized phase II study (NCT03121846) to assess the efficacy and safety of apatinib in patients with stage IV sarcoma. recruited 64 sarcoma who had failed chemotherapy. The primary endpoint was progression-free survival (PFS), secondary endpoints were rate (PFR), objective response (ORR), disease control (DCR) at week 12. Treatment-related...
Immunotherapy is an essential therapy for individuals with advanced melanoma. However, not all patients respond to such treatment due individual differences. We conducted a multidimensional analysis using transcriptome data from our center, as well publicly available databases. found that effective nivolumab led upregulation of C2 levels, and higher levels following are indicative good outcome. Through bioinformatics analyses immunofluorescence, we identified correlation between M1...
<div>AbstractPurpose:<p>We aimed to investigate the efficacy and safety of anlotinib as adjuvant targeted therapy for completely resected localized high-grade soft-tissue sarcomas (STS).</p>Patients Methods:<p>Patients with STS after complete resection were randomly assigned in a 1:1 ratio receive either oral 12 mg or placebo once daily on days 1 14 every 21 cycle, up six cycles until disease relapse, unmanageable toxicity, death. The analyzed. This trial was first...
<p>Supplementary Figure S1. Kaplan-Meier Curve showing the 1-year real-world recurrence-free survival (rwRFS) rate in UPS patients with and without adjuvant anlotinib therapy.</p>
To investigate associations between WW domain-containing oxidoreductase (WWOX), runt-related transcription factor 2 (RUNX2) and vascular endothelial growth alpha (VEGFA) in human osteosarcoma (OS). Copy number aberrations of WWOX, RUNX2and VEGFA genes were detected by microarray comparative genomic hybridization (aCGH) 10 fresh OS tissue samples. gene alterations also investigated validated fluorescence situ (FISH) 54 formalin-fixed paraffin-embedded (FFPE) Protein expression RUNX2 examined...
Mammalian milk is a key source of lipids, providing not only important calories but also essential fatty acids. Veterinary medicine and omics systems sciences intersection, termed as "veterinomics" here, has received little attention to date stands offer much promise for building bridges between human animal health. We determined the changes in porcine mammary genes proteomics expression associated with triacylglycerol (TAG) synthesis secretion from late pregnancy lactation. TAG content acid...
Abstract Extraskeletal osteosarcoma (ESOS) is an extremely rare malignancy with poor prognosis, accounting for 2–4% of all osteogenic sarcomas. The purpose this study was to examine the oncological outcomes disease related surgical treatment and/or combined adjuvant therapies and analyze associated prognostic factors in ESOS. From January 1990 June 2016, 22 patients primary ESOS were analyzed retrospective study. Overall survival (OS) progression-free (PFS) rates calculated by Kaplan-Meier...
This retrospective case-series study evaluated efficacy and safety of Endostar combined with chemotherapy in the treatment advanced bone soft tissue sarcomas stage IV.Forty-seven patients diagnosed IV treated Tianjin Medical University Cancer Institute & Hospital were reviewed. Of these patients, 23 plus (designated as group), 24 received only control group). Progression-free survival (PFS), overall (OS), objective response rate (ORR) clinical benefit (CBR) analyzed to find difference...
The rarity and complexity of soft tissue sarcoma (STS) make it a challenge to determine the incidence, survival, metastasis rates. In addition, clinicopathological risk factors for lymph node have rarely been reported.Data on patients diagnosed with STS in SEER database from 2000 2018 were extracted by SEER*Stat 8.3.9.1, incidence trend was calculated Joinpoint 4.9 software. KM method used calculate survival curve, log-rank compare differences curves. screened logistic regression.Among 35987...
Background Sarcoma is a highly heterogeneous malignancy with poor prognosis. Although chemotherapy and targeted therapy have improved the prognosis to some extent, efficacy remains unsatisfactory in patients. The safety of immunotherapy sarcoma need further evaluation. Methods We conducted two-center study patients receiving PD-1 at Tianjin Medical University Cancer Institute Hospital Henan Provincial Hospital. treatment regimens included inhibitor monotherapy combination based on...
Breast carcinomas show a trend toward bone metastasis that is prevalent worldwide. Celecoxib (CX) and minocycline hydrochloride (MH) have both been widely used in treating breast cancer; however, their combined effects on the osseous of cancer not yet studied. In present study, cells were injected into back femoral nude mice, CX MH intraperitoneally administered every other day at doses 30 40 mg/kg/day, respectively, for days. Tumor weights volumes significantly lower tumor inhibition rate...
There is no standard treatment for stage IV soft tissue sarcoma (STS) after the failure of Adriamycin-based chemotherapy. This phase II study (NCT03121846) assessed efficacy and safety apatinib (YN968D1), a new tyrosine kinase inhibitor that targets VEGFR-2, patients with STS chemotherapy failure.Forty-two subjects STSs who had failed received Apatinib were recruited between September 2015 February 2018. The primary endpoint was progression-free survival (PFS), secondary endpoints PFS rate...
<b>Objective:</b> To analyze the efficacy and safety of apatinib in treatment stage IV osteogenic sarcoma after chemotherapy failure through a single-arm, prospective, open clinical phase II study. <b>Methods:</b> Information on 34 patients with treated Tianjin Medical University Cancer Institute Hospital between September 2015 December 2019 was collected analyzed. The participants included 23 males 11 females, an average age 35.24 years (11–73 years). objective response rate (ORR), disease...
Abstract Through transcriptome sequencing, we previously identified a new osteosarcoma-specific, frequent fusion gene, LRP1 – SNRNP25 , and found that it played an important role in tumor cell invasion migration. However, the specific mechanism remains unclear. In this article, whole-genome sequencing further confirmed gene is formed by of exon 8 2. vitro, scratch Transwell assays demonstrated migration abilities LRP1–SNRNP25 -overexpressing osteosarcoma cells were significantly increased....
Drawing freehand sketches of mechanical components on multimedia devices for AI-based engineering modeling has become a new trend. However, its development is being impeded because existing works cannot produce suitable data-driven research. These either generate lacking style or utilize generative models not originally designed this task resulting in poor effectiveness. To address issue, we design two-stage framework mimicking the human sketching behavior pattern, called MSFormer, which...