A5071574297- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Thyroid Cancer Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Circular RNAs in diseases
- Barrier Structure and Function Studies
- Neurological Disease Mechanisms and Treatments
- Eicosanoids and Hypertension Pharmacology
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- BRCA gene mutations in cancer
- Growth Hormone and Insulin-like Growth Factors
- Molecular Biology Techniques and Applications
- Viral-associated cancers and disorders
- Alcohol Consumption and Health Effects
- AI in cancer detection
- Neonatal and fetal brain pathology
- Blood Coagulation and Thrombosis Mechanisms
- Cytokine Signaling Pathways and Interactions
- Thermal Regulation in Medicine
- Neuroscience and Neuropharmacology Research
Second Hospital of Hebei Medical University
2013-2023
Hebei Medical University
2013-2023
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2020
Second Affiliated Hospital of Zhejiang University
2020
Wenzhou Medical University
2018-2020
Cellular Research (United States)
2016
Hashimoto's thyroiditis (HT) is the main cause of hypothyroidism. We develop a deep learning model called HTNet for diagnosis HT by training on 106,513 thyroid ultrasound images from 17,934 patients and test its performance 5051 2 datasets static 1 dataset video data. achieves an area under receiver operating curve (AUC) 0.905 (95% CI: 0.894 to 0.915), 0.888 (0.836-0.939) 0.895 (0.862-0.927). exceeds radiologists' accuracy (83.2% versus 79.8%; binomial test, p < 0.001) sensitivity (82.6%...
Purpose: Recent studies have shown that long non-coding RNA (lncRNA) play an important role in cancer metabolism and development.The lncRNA small nucleolar host gene 7 (SNHG7) was reported to be upregulated colorectal contribute its progression.In the current study, we investigated of lncRNA-SNHG7 breast explored underlying mechanism.Methods: We monitored expression tissues cell lines.We evaluated effects on proliferation glycolysis cells by knocking down or overexpressing lncRNA-SNHG7.We...
Background/Aims: DNA HRR pathway and BER play vital roles in differentiated thyroid cancer (DTC) development, thus we supposed that polymorphisms of XRCC1, XRCC2, XRCC3 repair genes are associated with risk progression. Methods: We searched the NCBI database for relevant literatures to determine eight SNPs be included our study (XRCC1: rs25487, rs25489, rs1799782; XRCC2: rs3218536; XRCC3: rs1799794, rs56377012, rs1799796, rs861539). Results: SNP rs25487 was linked a 53% decrease DTC (OR:...
We previously have revealed that 1-trifluoromethoxyphenyl-3-(1- propionylpiperidin-4-yl) urea (TPPU), as a soluble epoxide hydrolase (sEH) inhibitor can reduce infarct volume, protect blood-brain barrier (BBB) and brain against ischemic injury in rats. Here, we investigated the potential mechanisms of TPPU on BBB integrity both permanent middle cerebral artery occlusion (pMCAO) rat model oxygen-glucose deprivation/reperfusion (OGD/R)-induced human microvascular endothelial cells (HBMVECs)...
Papillary thyroid cancer (PTC) is the most common endocrine malignant tumour. The purpose of this study was to explore potential molecular mechanism circRNA regulating immune-related mRNA through sponge miRNA in occurrence and immune regulation PTC.All data were downloaded from public databases, such as GEO, Immport TCGA. Differentially expressed (DE) mRNAs (DEmRNAs), DEmiRNAs DEcircRNAs identified using metaMA limma packages. Subsequently, DEmRNAs screened, circRNA-miRNA-mRNA (ceRNA)...
The aim of the present study was to investigate expression signal transducer and activator transcription 3 (STAT3) phosphorylated STAT3 (pSTAT3) in tissues papillary thyroid cancer (PTC) comparison with adjacent normal tissues. STAT3, pSTAT3, fibroblast growth factor 2 (FGF2) vascular endothelial factor-C (VEGF-C) examined 42 cases PTC 20 using immunohistochemistry western blotting. association between levels clinicopathological features analyzed. FGF2 VEGF-C (76.2, 42.9, 81.0 73.8%,...
Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) protects brain against focal ischemia in rats. Here explored mechanism TPPU action by assessing whether it could preserve blood-brain barrier integrity and reduce apoptosis during permanent middle cerebral artery...
Recombinant tissue plasminogen activator (rt-PA) is used to treat acute ischemic stroke but only effective if administered within 4.5 h after onset. Delayed rt-PA treatment causes blood-brain barrier (BBB) disruption and hemorrhagic transformation. The compound 2-(-2-benzofuranyl)-2-imidazoline (2-BFI), a newly discovered antagonist of high-affinity postsynaptic N-methyl-D-aspartate (NMDA) receptors, has been shown have neuroprotective effects in ischemia. Here, we investigated whether...
We previously demonstrated that administering 2-(2-benzofuranyl)-2-imidazolin (2-BFI), an imidazoline I2 receptor agonist, immediately after ischemia onset can protect the brain from ischemic insult. However, immediate administration stroke is difficult to realize in clinic. Thus, therapeutic time window of 2-BFI should be determined. Sprague-Dawley rats provided by Wenzhou Medical University China received right middle cerebral artery occlusion for 120 minutes, and were treated with (3...
Objective To discuss the relationship between thyroid carcinoma and epstein-barr virus (EBV) infection.Methods 155 cases of surgical resection specimen patients with cancer were selected as research object,and divided into groups according to WHO histological classification,and pericarcinomatous normal tissue control.Then we applied immunohistochemical method insitu molecules hybridization detect expression latent membrane protein-1 (LMP-1) Epstein-Barr encoded RNAs-1 (EBER-1) in adjacent...
Thyroid cancers are the most common malignancy of endocrine system. Increasing evidence has suggested potential roles for cancer susceptibility candidate 15 (CASC15) in thyroid cancer. Papillary (PTC) accounts 80% cancer, posing a great threat to public health. The present study aims investigate CASC15 PTC.PTC tissues were obtained from patients diagnosed with PTC at Second Hospital Hebei Medical University October 2016 January 2018. qRT-PCR was performed examine mRNA levels CASC15,...