A5049085403- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Physical Activity and Health
- Advanced MRI Techniques and Applications
- Diet and metabolism studies
- Retinal Imaging and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Nutrition and Health in Aging
- Folate and B Vitamins Research
- Acute Myocardial Infarction Research
- Birth, Development, and Health
- Frailty in Older Adults
- Advanced Neuroimaging Techniques and Applications
- Fatty Acid Research and Health
- Agriculture Sustainability and Environmental Impact
- Skin and Cellular Biology Research
- Child Abuse and Related Trauma
Loma Linda University
2009-2022
California State University Los Angeles
2022
Northern Arizona University
2022
Cedars-Sinai Medical Center
2015-2017
Columbia University
2015-2017
City of Hope
2017
Columbia University Irving Medical Center
2015
Loma Linda University Medical Center
2009-2014
University of California, San Diego
2008-2012
National Institute of Neurological Disorders and Stroke
2003
<b><i>Background:</i></b> Observations in animal models suggest that A<sub>2A</sub> antagonists confer benefit by modulating dopaminergic effects on the striatal dysfunction associated with motor disability. This double-blind, placebo-controlled, proof-of-principle study evaluated pathogenic contribution and therapeutic potential of adenosine receptor–mediated mechanisms Parkinson disease (PD) levodopa-induced complications. <b><i>Methods:</i></b> Fifteen patients moderate to advanced PD...
Despite advances in imaging retinal amyloidosis, a quantitative and topographical investigation of amyloid beta burden patients with cognitive decline has never been reported.
The purpose of this article was to explore sex- and race-specific variables comorbidities associated with transient global amnesia (TGA) using a nationally representative database. Data were obtained from the Nationwide Inpatient Sample ICD-9 procedure codes. Descriptive survey logistic regression analyses conducted adjusted for influence comorbidities, demographic characteristics, hospitalization-related factors. Patients migraines 5.98 times more likely also have diagnosis TGA compared...
Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory curcumin-fluorescence (RFI) study, we sought determine whether vascular features combined with amyloid burden correlate the neurocognitive status.We used quantitative RFI in cohort of patients cognitive impairment automatically compute burden. blood vessels were segmented, vessel tortuosity index (VTI), inflection index, branching angle quantified. We assessed correlations...
Background Prior studies show an increased risk of ischemic stroke ( IS ) after myocardial infarction; however, there is limited evidence on long‐term and whether it directly related to cardiac injury. We hypothesized that the acute coronary syndrome significantly higher if injury, such as ST‐segment elevation infarction STEMI or non‐ , than when no in unstable angina. Methods Results Administrative claims data were obtained from all emergency department encounters hospitalizations at...
Background and Purpose— Whether changes in leisure-time physical activity (LTPA) over time are associated with lower risk of stroke is not well established. We examined the association between self-reported LTPA 10 years apart, incident CTS (California Teachers Study). hypothesized that would be lowest among those who remained active. Methods— Sixty-one thousand two hundred fifty-six participants reported at 2 intensity levels (moderate strenuous activity) points (baseline 1995–96; 10-year...
Dementia is the fastest growing epidemic in developed nations, and if not curtailed, it will single handedly collapse our health care system. The prevalence of dementia 1 10 individuals older than 65 years increases to 50% all 85 years. Alzheimer's (AD), most common form dementia, has been increasing rapidly projected reach 16 million by year 2050. Several prevailing myths about science are discussed, such as that AD inevitable exclusively a genetic disease. fact dependent on multitude...
Introduction: Studies have demonstrated an inverse relationship between Alzheimer dementia (AD) and cancer. This was further explored. In addition, Pin1 expression has been implicated in the cell cycle regulation of both disease processes. The 10 cancer types secondary diagnosis AD examined. Materials Methods: A cross-sectional analysis performed using discharge data from National Inpatient Sample 1999 to 2008. Cancer defined as primary diagnosis. were grouped according their examine its...
Background/Aim: To date, few studies have cross-examined the relationship between diabetes mellitus (DM) and dementia nationally. There is also a lack of evidence regarding subtypes how this changes among older individuals. The objective was to better delineate influence multiple comorbidities using nationwide sample. Methods: Data were obtained from Nationwide Inpatient Sample 1998 2011 appropriate International Classification Diseases, Ninth Version codes. Descriptive bivariate analysis...
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Although precise pathogenetic mechanisms of PD remain undetermined, there appears to be both genetic and environmental factors that contribute risk developing PD. With regard factors, has been significant interest related role diet, nutrition, nutrients on onset progression As current treatments are predominantly focused symptomatic management, efforts must directed toward prevention identification potentially...
Dementia with Lewy bodies (DLB) is characterized neuropathologically by brainstem and cortical neurites, neuronal loss in nuclei, Alzheimer disease (AD) pathology. Previous studies have suggested that spongiform change the entorhinal cortex may also be a pathologic feature; however, this has not been well characterized.
Symptomatic intracerebral hemorrhage (sICH) occurs in up to 7% of stroke patients treated with thrombolytic therapy. There are limited data on the effectiveness reversal agents used for intravenous tissue plasminogen activator related intracranial bleeds. We report a patient sICH following thrombolysis whose continued expand despite treatment platelets and cryoprecipitate, needing recombinant factor VIIa use stabilization before surgical evacuation. Factor along routine may further enhance...