A5001429661- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Blood Pressure and Hypertension Studies
- Advanced MRI Techniques and Applications
- Aging and Gerontology Research
- Acute Ischemic Stroke Management
- Neurobiology of Language and Bilingualism
- Health, Environment, Cognitive Aging
- Health disparities and outcomes
- Optimism, Hope, and Well-being
- Parkinson's Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Cognitive Functions and Memory
- Frailty in Older Adults
- Memory and Neural Mechanisms
- MRI in cancer diagnosis
- Cardiac Arrest and Resuscitation
- Older Adults Driving Studies
University of California, San Diego
2016-2025
VA San Diego Healthcare System
2016-2025
Rady Children's Hospital-San Diego
2021
San Diego State University
2007-2019
La Jolla Alcohol Research
2018
Institute on Aging
2013-2014
Massachusetts Institute of Technology
2008
Rush University Medical Center
2004-2008
University of Illinois Chicago
2008
Stanford University
2004-2008
Racial disparities in late-life cognition persist even after accounting for educational attainment. We examined whether early-life quality and literacy later life help explain these disparities. used longitudinal data from the Washington Heights-Inwood Columbia Aging Project (WHICAP). Educational (percent white students; urban/rural school; combined grades classroom) was operationalized using canonical correlation analysis. Late-life (reading comprehension ability, writing) confirmatory...
Objective Our objectives were to characterize the inter‐relation of known dementia‐related neuropathologies in one comprehensive model and quantify extent which accumulation accounts for association between age dementia. Methods We used data from 1,362 autopsied participants three community‐based clinicopathological cohorts: Religious Orders Study, Rush Memory Aging Project, Minority Research Study. estimated a series structural equation models summarizing priori hypothesized...
Objective: To compare fMRI activation during two visual stimulation paradigms in Parkinson disease (PD) subjects with chronic hallucinations vs PD patients who had never hallucinated.
Patients with ischemic stroke are at risk for developing vascular cognitive impairment ranging from mild impairments to dementia. MRI findings of infarction, white matter hyperintensities, and global cerebral atrophy have been implicated in the development impairment. The present study investigated regional gray volume differences between patients no those least one domain function.Ninety-one participated. Detailed neuropsychological testing was used characterize functioning 7 domains:...
Abstract Given the importance of identifying dementia prodromes for future treatment efforts, we examined two methods diagnosing mild cognitive impairment (MCI) and determined whether empirically-derived MCI subtypes these diagnostic were consistent with one another as well conventional (i.e., amnestic, non-amnestic, single-domain, multi-domain). Participants diagnosed using either Petersen/Winblad criteria ( n = 134; >1.5 SD s below normal on test within a domain) or comprehensive...
Increased pulse pressure associated with age-related arterial stiffening increases risk for Alzheimer dementia but the mechanism responsible this association remains unclear.To determine relationship between and cerebral spinal fluid biomarker profiles of preclinical disease, investigate whether observed relationships are stronger in adults more advanced age (≥80 years age), examine progression to dementia.In retrospective cohort study, 877 participants without (55-91 age) from Alzheimer's...
<h3>Objective</h3> To determine the temporal sequence of objectively defined subtle cognitive difficulties (Obj-SCD) in relation to amyloidosis and neurodegeneration, current study examined trajectories amyloid PET medial neurodegeneration participants with Obj-SCD relative cognitively normal (CN) mild impairment (MCI) groups. <h3>Method</h3> A total 747 Alzheimer9s Disease Neuroimaging Initiative (305 CN, 153 Obj-SCD, 289 MCI) underwent neuropsychological testing serial structural MRI...
Abstract We examined the relationships of antemortem vascular risk factors to postmortem cerebrovascular and Alzheimer's disease (AD) pathologies. Eighty‐four AD patients underwent an assessment (blood pressure, cholesterol, smoking, cardiovascular disease, diabetes, atrial fibrillation, transient ischemic attack [TIA], or stroke) later brain autopsy. Given our aim examine mild changes (CVCs), individuals were excluded if autopsy revealed large stroke. The most common forms CVC circle Willis...
Type 2 diabetes mellitus (T2DM) increases risk for dementia, including Alzheimer's disease (AD). Many previous studies of brain changes underlying cognitive impairment in T2DM have applied conventional structural magnetic resonance imaging (MRI) to detect macrostructural associated with cerebrovascular (CVD) such as white matter hyperintensities (WMH) or infarcts. However, pathology likely reflects end-stage manifestations chronic decrements cerebral blood flow (CBF). MRI techniques that...
Abstract There is increasing consensus regarding the importance of operationally defining and measuring functional decline in mild cognitive impairment (MCI). However, few studies have directly examined abilities MCI or its presumed subtypes and, to date, reported findings been discrepant. Nondemented older adults ( n = 120) were administered a comprehensive battery multiple domains as well performance-based ability measure. Participants characterized either cognitively normal, amnestic MCI,...
Functional magnetic resonance imaging (fMRI) of older adults at risk for Alzheimer's disease (AD) by virtue their cognitive (i.e., mild impairment [MCI]) and/or genetic apolipoprotein E [APOE] ε4 allele) status demonstrate divergent brain response patterns during memory encoding across studies. Using arterial spin labeling MRI, we examined the influence AD on resting cerebral blood flow (CBF) as well CBF and oxygenation level dependent (BOLD) signal to in medial temporal lobes (MTL) 45 (29...
Wisdom has been reported to be associated with better mental health and quality of life among older adults. Over the past decades, there considerable growth in empirical research on wisdom, including development standardized measures. The 39-item Three-Dimensional Scale (3D-WS) is a useful assessment tool, given its rigorous good psychometric properties. However, measure's length can prohibit use. In this article, we used sample 1,546 community-dwelling adults aged 21 100 years (M = 66...
Objectives To examine the association between diabetes mellitus and cognitive functioning at baseline change over time in a large, ethnically diverse sample of older adults. Design Prospective cohort study. Setting Washington Heights–Inwood Columbia Aging Project, community‐based, prospective study risk factors for dementia northern Manhattan, New York City. Participants Hispanic, non‐Hispanic black, white men women aged 65 without (N = 1,493). Measurements underwent follow‐up health...
Vascular risk factors and cerebral blood flow (CBF) reduction have been linked to increased of cognitive impairment Alzheimer's disease (AD); however the possible moderating effects age vascular burden on CBF in late life remain understudied. We examined relationships among elevated burden, age, CBF, cognition. Seventy-one non-demented older adults completed an arterial spin labeling MR scan, neuropsychological assessment, medical history interview. Relationships were a priori regions...
Using whole-brain pulsed arterial spin labeling magnetic resonance imaging, resting cerebral blood flow (CBF) was measured in 20 mild cognitive impairment (MCI; 11 ε3 and 9 ε4) 40 demographically matched cognitively normal (CN; 27 13 participants. An interaction of apolipoprotein (APOE) genotype ( status (CN MCI) on quantified gray-matter CBF corrected for partial volume effects found the left parahippocampal fusiform gyri (PHG/FG), right middle frontal gyrus, medial gyrus. In PHG/FG,...
The amyloid cascade model of Alzheimer's disease posits the primacy beta deposition preceding tau-mediated neurofibrillary tangle formation. amyloid-tau-neurodegeneration biomarker-only diagnostic framework similarly requires presence for a diagnosis on continuum. However, medial temporal lobe tau pathology in absence is frequently observed at autopsy cognitively normal individuals, phenomenon that may reflect consequence aging and has been labelled 'primary age-related tauopathy'....
Introduction: We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline conversion from normal cognition to MCI follow-up. Methods: Framingham Offspring participants underwent brain MRI neuropsychological assessment (n=1049) follow-up (n=561). Participants were classified as cognitively or using sensitive criteria. White matter hyperintensity (WMH) volume, covert...
Apolipoprotein E (APOE) interacts with Alzheimer's disease pathology to promote progression. We investigated the moderating effect of APOE on independent associations amyloid and tau positron emission tomography (PET) cognition.For 297 nondemented older adults from Disease Neuroimaging Initiative, regression equations modeled between cognition (1) cortical beta (Aβ) PET levels adjusting for (2) medial temporal lobe (MTL) Aβ, including interactions ε4-carrier status.Adjusting PET, Aβ was not...