A5027093612- Dementia and Cognitive Impairment Research
- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Noise Effects and Management
- Health disparities and outcomes
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Climate Change and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Health and Risk Factors
- Heavy Metal Exposure and Toxicity
- Advanced Causal Inference Techniques
- Nutritional Studies and Diet
- Air Quality Monitoring and Forecasting
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Advanced Neuroimaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Geriatric Care and Nursing Homes
- Traumatic Brain Injury Research
- Cardiovascular Disease and Adiposity
- Hearing Loss and Rehabilitation
- Cardiac Arrest and Resuscitation
Milken Institute
2016-2024
George Washington University
2016-2024
Gates Foundation
2017-2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Johns Hopkins University
2014-2021
University of Mississippi Medical Center
2015-2021
Jackson Memorial Hospital
2015-2021
Mayo Clinic in Arizona
2015-2021
<h3>Importance</h3> Hypertension is a treatable potential cause of cognitive decline and dementia, but its greatest influence on cognition may occur in middle age. <h3>Objective</h3> To evaluate the association between midlife (48-67 years age) hypertension 20-year change performance. <h3>Design, Setting, Participants</h3> The Atherosclerosis Risk Communities cohort (1990-1992 through 2011-2013) underwent evaluation at field centers Washington County, Maryland, Forsyth North Carolina,...
Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment.We assessed the association between black carbon (BC), a marker of traffic-related air pollution, cognition in older men.A total 680 men (mean ± SD, 71 7 years age) from U.S. Department Veterans Affairs Normative Aging Study completed battery seven tests at least once 1996 2007. We long-term exposure to pollution using validated...
<b>Objective</b> To determine whether higher past exposure to particulate air pollution is associated with prevalent high symptoms of anxiety. <b>Design</b> Observational cohort study. <b>Setting</b> Nurses’ Health Study. <b>Participants</b> 71 271 women enrolled in the Study residing throughout contiguous United States who had valid estimates on matter for at least one period interest and data anxiety symptoms. <b>Main outcome measures</b> Meaningfully anxiety, defined as a score 6 points...
The association between late-life blood pressure (BP) and cognition may depend on the presence chronicity of past hypertension. Late-life declines in following prolonged hypertension be associated with poor cognitive outcomes.To examine midlife to BP patterns subsequent dementia, mild impairment, decline.The Atherosclerosis Risk Communities prospective population-based cohort study enrolled 4761 participants during (visit 1, 1987-1989) followed-up over 6 visits through 2016-2017 6). was...
Objective Our objectives were to characterize the inter‐relation of known dementia‐related neuropathologies in one comprehensive model and quantify extent which accumulation accounts for association between age dementia. Methods We used data from 1,362 autopsied participants three community‐based clinicopathological cohorts: Religious Orders Study, Rush Memory Aging Project, Minority Research Study. estimated a series structural equation models summarizing priori hypothesized...
Despite recently reported associations between air pollution and acute psychiatric outcomes, the association with depression onset has not, to our knowledge, been previously examined. We conducted a prospective cohort study among 41,844 women in Nurses’ Health Study, United States. The had an average age of 66.6 (standard deviation, 7.6) years, were depression-free 1996, followed through 2008. May–September ozone exposures predicted by interpolating concentrations from 5 nearest monitors....
OBJECTIVE We sought to examine associations in older adults among diabetes, glycemic control, diabetes duration, and biomarkers of hyperglycemia with incident mild cognitive impairment (MCI) dementia. RESEARCH DESIGN AND METHODS conducted a prospective analysis 5,099 participants from the Atherosclerosis Risk Communities (ARIC) Study who attended fifth (2011–2013) exam. Cognitive status was assessed during follow-up via telephone calls, death certificate codes, surveillance, examination...
Systematic disparities in misdiagnosis of dementia across racial/ethnic groups have implications for health disparities. We compared the risk under- and overdiagnosis clinical settings from 2000 to 2010.We linked fee-for-service Medicare claims participants aged ≥70 nationally representative Health Retirement Study. classified status using an algorithm with similar sensitivity specificity assigned diagnosis ICD-9-CM codes claims. Multinomial logit models were used estimate relative risks...
Abstract Introduction Existing studies predominantly consider the association of late‐life lipid levels and subsequent cognitive change. However, midlife rather than risk factors are often most relevant to health. Methods We quantified between measured serum lipids in 20‐year change performance on three tests 13,997 participants Atherosclerosis Risk Communities study. Results Elevated total cholesterol, low‐density lipoprotein triglycerides were associated with greater decline a test...
In the US, dementia risk is higher in non-Hispanic Black individuals than White individuals. To evaluate progress toward reducing such disparities, tracking secular trends racial disparities prevalence essential.To examine whether relative or incidence have changed US from 2000 to 2016.The Health and Retirement Study (HRS) a nationally representative study of adults 50 years older. New participants are recruited every 6 years, visits occur biennially. Approximately 17 000 22 respondents been...
Studies of long-term cognitive change should account for the potential effects education on outcome, since some studies have demonstrated an association with dementia risk. Evaluating is more ideal than evaluating performance at a single time point, because it be less susceptible to confounding. In this analysis 14,020 persons from US cohort study, Atherosclerosis Risk in Communities (ARIC) Study, we measured 3 tests over 20-year period, ages 48-67 years (1990-1992) through 70-89...
OBJECTIVES Understanding how dementia risk is impacted by timing of smoking cessation has public health implications for prevention efforts. We investigated the relationship cigarette and with cognitive decline in Atherosclerosis Risk Communities (ARIC) study. DESIGN Ongoing prospective cohort SETTING Begun 1987‐1989, ARIC was conducted four US communities. PARTICIPANTS A total 13 002 men women (25% African American) aged 52 to 75 years. MEASUREMENTS All‐cause defined using standardized...
Background: Increasing evidence links higher particulate matter (PM) air pollution exposure to late-life cognitive impairment. However, few studies have considered associations between direct estimates of long-term past exposures and brain MRI findings indicative neurodegeneration or cerebrovascular disease. Objective: Our objective was quantify the association PM approximately 5 20 y prior in Atherosclerosis Risk Communities (ARIC) study. Methods: ARIC is based four U.S. sites: Washington...
Background and Purpose— It is currently unclear whether midlife systemic inflammation promotes the development of white matter (WM) abnormalities small vessel disease in elderly. We examined association with late-life WM hyperintensity volume, deep periventricular microstructural integrity (fractional anisotropy mean diffusivity [MD]), cerebral infarcts, microbleeds a biracial prospective cohort study. Methods— Linear logistic regression relation between high-sensitivity C-reactive protein...
<h3>Objective:</h3> Our objective was to examine the link between smoking and history, including intensity cessation, overall by race, in a biracial prospective cohort study. <h3>Methods:</h3> A subset of Atherosclerosis Risk Communities Study participants (n = 972, 49% black) completed brain MRI scans twice (1993–1995 2004–2006). We defined white matter hyperintensity (WMH) progression as an increase ≥2 points on 9-point Cardiovascular Health scale across scans. Participants reported...
Improvements in cognitive test scores upon repeated assessment due to practice effects (PEs) are well documented, but there is no empirical evidence on whether alternative specifications of PEs result different estimated associations between exposure and rate change. If PE produce estimates association an change, this would be a challenge for nearly all longitudinal research determinants aging. Using data from 3 cohort studies—the Three-City Study–Dijon (Dijon, France, 1999–2010), the...