A5075061959- Cardiovascular Health and Risk Factors
- Nutritional Studies and Diet
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Blood Coagulation and Thrombosis Mechanisms
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Genetic Associations and Epidemiology
- Cardiovascular Function and Risk Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Blood properties and coagulation
- Cardiac Imaging and Diagnostics
- Cancer Risks and Factors
- Acute Myocardial Infarction Research
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Lipids, and Metabolism
- Obesity, Physical Activity, Diet
- Atrial Fibrillation Management and Outcomes
- Acute Ischemic Stroke Management
- Peripheral Artery Disease Management
- Platelet Disorders and Treatments
- Nutrition and Health in Aging
- Heart Rate Variability and Autonomic Control
University of Minnesota
2015-2024
University of Minnesota System
2006-2024
Minnesota Department of Health
2013-2023
Johns Hopkins University
2012-2023
Baylor College of Medicine
2011-2023
Houston Methodist
2004-2023
University of Pennsylvania
2008-2023
National Institute on Aging
2003-2023
Emory University
2016-2023
National Institute of Neurological Disorders and Stroke
2023
In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently traditional risk factors. However, it is not known whether predicts in other racial or ethnic groups.We collected data on factors and performed scanning for a population-based sample 6722 men women, whom 38.6% were white, 27.6% black, 21.9% Hispanic, 11.9% Chinese. The study subjects had no clinical cardiovascular at entry followed median 3.8 years.There 162 events,...
A high body-mass index (BMI, the weight in kilograms divided by square of height meters) is associated with increased mortality from cardiovascular disease and certain cancers, but precise relationship between BMI all-cause remains uncertain.
Coronary heart disease (CHD) is a major cause of death in Western countries. We used genome-wide association scanning to identify 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which located near the CDKN2A and CDKN2B genes, contains no annotated genes not established risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for...
There is debate about the value of assessing levels C-reactive protein (CRP) and other biomarkers inflammation for prediction first cardiovascular events.We analyzed data from 52 prospective studies that included 246,669 participants without a history disease to investigate adding CRP or fibrinogen conventional risk factors risk. We calculated measures discrimination reclassification during follow-up modeled clinical implications initiation statin therapy after assessment fibrinogen.The...
To examine the association of low-grade systemic inflammation with diabetes, as well its heterogeneity across subgroups, we designed a case-cohort study representing ∼9-year experience 10,275 Atherosclerosis Risk in Communities Study participants. Analytes were measured on stored plasma 581 incident cases diabetes and 572 noncases. Statistically significant hazard ratios developing for those fourth (versus first) quartile markers, adjusted age, sex, ethnicity, center, parental history...
The role of dietary antioxidant vitamins in preventing coronary heart disease has aroused considerable interest because the knowledge that oxidative modification low-density lipoprotein may promote atherosclerosis.We studied 34,486 postmenopausal women with no cardiovascular who early 1986 completed a questionnaire assessed, among other factors, their intake A, E, and C from food sources supplements. During approximately seven years follow-up (ending December 31, 1992), 242 died disease.In...
Most epidemiologic studies of cardiovascular disease in postmenopausal women suggest that estrogen-replacement therapy has a protective effect. The effects the use estrogen combined with progestin are less well studied.
Background— Although brachial artery flow-mediated dilation (FMD) predicts recurrent cardiovascular events, its predictive value for incident disease (CVD) events in adults free of CVD is not well established. We assessed the FMD Multi-Ethnic Study Atherosclerosis (MESA). Methods and Results— Brachial was measured a nested case-cohort sample 3026 6814 subjects (mean±SD age, 61.2±9.9 years) MESA, population-based cohort study clinical at baseline recruited 6 clinic sites United States. The...
Background —Low heart rate variability (HRV) is associated with a higher risk of death in patients disease and elderly subjects incidence coronary (CHD) the general population. Methods Results —We studied predictive value HRV for CHD from several causes population study 14 672 men women without CHD, aged 45 to 65, by using case-cohort design. At baseline, 1987 1989, 2-minute rhythm strips were recorded. Time-domain measures determined random sample 900 subjects, all incident (395 subjects),...
Although stroke mortality rates in the United States are well documented, assessment of incidence and case fatality less studied.A cohort 15 792 men women aged 45 to 64 years from a population sample households 4 US communities was followed 1987 1995, an average 7. 2 years. Incident strokes were identified through annual phone contacts hospital record searching then validated.Of 267 incident definite or probable strokes, 83% (n=221) categorized as ischemic 10% (n=27) intracerebral...
Although hemostatic factors contribute to acute coronary syndromes and atherogenesis, few studies have prospectively evaluated the association between multiple heart disease incidence.The Atherosclerosis Risk in Communities Study recruited 14,477 adults from 45 64 years of age who were initially free disease. Coronary risk several plasma measured, incidence was ascertained during an average follow-up 5.2 years. Age-, race-, field center-adjusted relative risks significantly elevated (P < or...
Background— We evaluated whether cardiac troponin T (cTnT) measured with a new highly sensitive assay was associated incident coronary heart disease (CHD), mortality, and hospitalization for failure (HF) in general population of participants the Atherosclerosis Risk Communities (ARIC) Study. Methods Results— Associations between increasing cTnT levels CHD, HF were Cox proportional hazards models adjusted traditional CHD risk factors, kidney function, high-sensitivity C-reactive protein,...
Mortality from coronary heart disease (CHD) has declined in the United States since late 1960s. To understand reasons for decline during period 1985 to 1990, we examined trends mortality and morbidity due CHD, medical care, risk factors CHD a large metropolitan population.
Context-Coronary artery calcium (CAC) and carotid intima-media thickness (IMT) are noninvasive measures of atherosclerosis that consensus panels have recommended as possible additions to risk factor assessment for predicting the probability cardiovascular disease (CVD) occurrence.Objective-To assess whether maximum IMT or CAC (Agatston Score) is better predictor incident CVD.Design, Setting, Patients-Prospective cohort study 45-84 year-olds initially free CVD (n = 6,698) in four ethnic...
<h3>Background</h3> The association between traditional cardiovascular risk factors and of venous thromboembolism (VTE) has not been extensively examined in prospective studies. <h3>Methods</h3> To determine whether atherosclerotic are also associated with increased incidence VTE, we conducted a study 19 293 men women without previous VTE 6 US communities 1987 1998. <h3>Results</h3> There were 215 validated events (1.45 per 1000 person-years) during median 8 years follow-up. age-adjusted...
Background: Recent clinical guidelines on the health risks of obesity use body mass index (BMI; calculated as weight in kilograms divided by square height meters) and waist circumference, but waist-hip ratio may provide independent information. Methods:To assess joint relative associations BMI, with multiple disease end points, we conducted a prospective cohort study 31 702 Iowa women, aged 55 to 69 years free cancer, heart disease, diabetes, assembled random sampling mail survey 1986.Study...
Experiments in animals, international correlation comparisons, and case-control studies support an association between dietary fat intake the incidence of breast cancer. Most cohort do not corroborate association, but they have been criticized for involving small numbers cases, homogeneous intake, measurement errors estimates intake.