David Couper
A5089417042- Chronic Obstructive Pulmonary Disease (COPD) Research
- Macrophage Migration Inhibitory Factor
- GDF15 and Related Biomarkers
- Apelin-related biomedical research
- Asthma and respiratory diseases
- Genetic Associations and Epidemiology
- Retinal Imaging and Analysis
- Nuclear Receptors and Signaling
- Cardiovascular Health and Disease Prevention
- Respiratory Support and Mechanisms
- Cardiovascular Health and Risk Factors
- Blood Pressure and Hypertension Studies
- Retinal Diseases and Treatments
- Pediatric health and respiratory diseases
- Cardiovascular Disease and Adiposity
- Retinal and Optic Conditions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Cancer, Lipids, and Metabolism
- Smoking Behavior and Cessation
- Lung Cancer Diagnosis and Treatment
- Noise Effects and Management
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Nutrition, Genetics, and Disease
University of North Carolina at Chapel Hill
2016-2025
Johns Hopkins University
2005-2025
Columbia University
2025
University of California, Los Angeles
2025
Resonance Research (United States)
2025
Wake Forest University
2009-2025
University of Illinois Chicago
2025
Cornell University
2025
University of North Carolina Health Care
2018-2024
Google (United States)
2024
Alcohol dependence treatment may include medications, behavioral therapies, or both. It is unknown how combining these treatments impact their effectiveness, especially in the context of primary care and other nonspecialty settings.To evaluate efficacy medication, combinations for alcohol to placebo effect on overall outcome.Randomized controlled trial conducted January 2001-January 2004 among 1383 recently alcohol-abstinent volunteers (median age, 44 years) from 11 US academic sites with...
To examine the association of low-grade systemic inflammation with diabetes, as well its heterogeneity across subgroups, we designed a case-cohort study representing ∼9-year experience 10,275 Atherosclerosis Risk in Communities Study participants. Analytes were measured on stored plasma 581 incident cases diabetes and 572 noncases. Statistically significant hazard ratios developing for those fourth (versus first) quartile markers, adjusted age, sex, ethnicity, center, parental history...
OF microvascular and macrovascular processes to the risk of coronary heart disease (CHD) is unknown, but its elucidation important from etiological, preventive, therapeutic perspectives. 1,2Coronary may explain occurrence myocardial ischemia without overt artery blockage, [3][4][5][6][7] as well failure 8,9 mortality 9 after infarction (MI).Because women with chest pain are more likely have normal arteries, 1-4,7 higher rates an MI, 10,11 poorer outcomes bypass graft surgery, 12 it has been...
Background Tools for the prediction of atrial fibrillation ( AF ) may identify high‐risk individuals more likely to benefit from preventive interventions and serve as a benchmark test novel putative risk factors. Methods Results Individual‐level data 3 large cohorts in U nited S tates (Atherosclerosis Risk Communities [ ARIC ] study, Cardiovascular Health Study CHS ], Framingham Heart FHS ]), including 18 556 men women aged 46 94 years (19% A frican mericans, 81% whites) were pooled derive...
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects European ancestry after imputation using 1000 Genomes multiethnic reference panel. Promising signals were followed up in additional sets (of 14,545 or 7,397 38,994 71,604 subjects). We identified 13 novel T2D-associated loci (P < 5 × 10-8), including variants near GLP2R, GIP, HLA-DQA1...
Currently, the diagnosis of chronic obstructive pulmonary disease (COPD) requires a ratio forced expiratory volume in 1 second (FEV1) to vital capacity (FVC) less than 0.70 as assessed by spirometry after bronchodilator use. However, many smokers who do not meet this definition have respiratory symptoms.
Context White matter lesions (WMLs) detected on cerebral imaging scans have been hypothesized to a microvascular etiology and precede the development of clinical stroke.However, few data are available support these hypotheses.Objective To examine relationship WMLs, retinal abnormalities, incident stroke in healthy, middle-aged men women. Design SettingThe Atherosclerosis Risk Communities Study (ARIC), prospective, population-based cohort study conducted 4 US communities initiated...
Naltrexone hydrochloride treatment for alcohol dependence works some individuals but not everyone. Asn40Asp, a functional polymorphism of the mu-opioid receptor gene (OPRM1), might predict naltrexone response.To evaluate whether with alcoholism who are heterozygous (Asp40/Asn40) or homozygous (Asp40/Asp40) OPRM1 Asp40 allele respond better to naltrexone.Pharmacogenetic analysis conducted between January 1, 2001, and 31, 2004.Eleven academic sites in COMBINE Study.Recently abstinent...
To investigate the relationship between plasma levels of small dense low-density lipoprotein-cholesterol (sdLDL-C) and risk for incident coronary heart disease (CHD) in a prospective study among Atherosclerosis Risk Communities (ARIC) participants.
Periodontitis has been linked to clinical cardiovascular disease but not subclinical atherosclerosis. The purpose of this study was determine whether periodontitis is associated with carotid artery intima-media wall thickness (IMT). Cross-sectional data on 6017 persons aged 52 75 years were obtained from the Atherosclerosis Risk in Communities Study 1996 1998 examination. dependent variable IMT ≥1 mm. defined by extent attachment loss ≥3 mm: none/mild (<10%), moderate (10% <30%), or...
Type 2 diabetes is associated with dementia risk, but evidence limited for possible associations of and prediabetes cognitive decline.To determine whether in midlife 20-year decline to characterize long-term across clinical categories hemoglobin A1c (HbA1c) levels.Prospective cohort study.The community-based ARIC (Atherosclerosis Risk Communities) study.13,351 black white adults aged 48 67 years at baseline (1990 1992).Diabetes was defined by self-reported physician diagnosis or medication...
Background— Results from studies relating periodontal disease to cardiovascular have been mixed. Residual confounding by smoking and use of clinical measures rather than infection 2 major criticisms. The aims this study were investigate relationships between prevalent coronary heart (CHD) exposures, (1) (2) IgG antibodies 17 oral organisms, evaluate the role in these relationships. Methods Results— Our is based on a subset participants Atherosclerosis Risk Communities (ARIC) Study, who...
Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development therapies for by providing robust criteria subclassifying participants into groups most likely benefit from given therapy during clinical trial, identifying biomarkers/phenotypes that can be used as intermediate outcomes reliably predict therapeutic trials. The goal enrol 3200 four strata. Participants...