A5012037644- Genetic Associations and Epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- AI in cancer detection
- Nutrition, Genetics, and Disease
- Genomics and Rare Diseases
- Statistical Methods in Clinical Trials
- Obstructive Sleep Apnea Research
- Lymphoma Diagnosis and Treatment
- Gene expression and cancer classification
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Neuroscience of respiration and sleep
- Diet, Metabolism, and Disease
- Genomic variations and chromosomal abnormalities
- Genetic and phenotypic traits in livestock
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- Prenatal Screening and Diagnostics
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sleep and related disorders
- Children's Physical and Motor Development
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
The University of Texas Health Science Center at Houston
2017-2025
Sichuan University
2022-2025
Shenzhen University
2025
Guangzhou Medical University
2019-2025
West China Second University Hospital of Sichuan University
2022-2025
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
The University of Texas MD Anderson Cancer Center
2013-2024
West China Hospital of Sichuan University
2024
Shanghai Jiao Tong University
2023-2024
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects European ancestry after imputation using 1000 Genomes multiethnic reference panel. Promising signals were followed up in additional sets (of 14,545 or 7,397 38,994 71,604 subjects). We identified 13 novel T2D-associated loci (P < 5 × 10-8), including variants near GLP2R, GIP, HLA-DQA1...
OBJECTIVE Proinsulin is a precursor of mature insulin and C-peptide. Higher circulating proinsulin levels are associated with impaired β-cell function, raised glucose levels, resistance, type 2 diabetes (T2D). Studies the processing pathway could provide new insights about T2D pathophysiology. RESEARCH DESIGN AND METHODS We have conducted meta-analysis genome-wide association tests ∼2.5 million genotyped or imputed single nucleotide polymorphisms (SNPs) fasting in 10,701 nondiabetic adults...
Abstract Summary The Genomic Data Storage (GDS) format provides efficient storage and retrieval of genotypes measured by microarrays sequencing. We developed GENESIS to perform various single- aggregate-variant association tests using genotype data stored in GDS format. implements highly flexible mixed models, allowing for different link functions, multiple variance components phenotypic heteroskedasticity. integrates cohesively with other R/Bioconductor packages build a complete genomic...
The role of enhancers, a key class non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization large number expressed enhancers genome-wide analysis 8928 tumor samples across 33 types using TCGA RNA-seq data. Compared with matched normal tissues, global enhancer activation was observed most cancers. Across types, activity positively associated aneuploidy, but not mutation load, suggesting hypothesis centered...
Bacterial genomics has revolutionized our understanding of the microbial tree life; however, mapping and visualizing distribution functional traits across bacteria remains a challenge. Here, we introduce AnnoTree—an interactive, functionally annotated bacterial life that integrates taxonomic, phylogenetic annotation data from over 27 000 1500 archaeal genomes. AnnoTree enables visualization millions precomputed genome annotations phylogenies, thereby allowing users to explore gene...
A large number of rare genetic variants have been discovered with the development in sequencing technology and lowering costs. Rare variant analysis may help identify novel genes associated diseases quantitative traits, adding to our knowledge explaining heritability these phenotypes. Many statistical methods for developed recent years, but some them require strong assumption that all share same direction effect, others requiring permutation calculate P ‐values are computer intensive. Among...
Summary Meta‐analysis is a powerful approach to combine evidence from multiple studies make inference about one or more parameters of interest, such as regression coefficients. The validity the fixed effect model meta‐analysis depends on underlying assumption that all in share same size. In presence heterogeneity, incorrectly ignores between‐study variance and may yield false positive results. random takes into account both within‐study variances. It conservative than should be favored...
Identification of single nucleotide polymorphisms (SNPs) associated with gene expression levels, known as quantitative trait loci (eQTLs), may improve understanding the functional role phenotype-associated SNPs in genome-wide association studies (GWAS). The small sample sizes some previous eQTL have limited their statistical power. We conducted an investigation microarray-based and exon levels whole blood a cohort 5257 individuals, exceeding size by more than factor 2.We detected over 19,000...
Theoretical reasoning suggests that cancer may result from a knockdown of the genetic constraints evolved for maintenance metazoan multicellularity. By characterizing whole-life history xenograft tumour, here we show metastasis is driven by positive selection general loss-of-function mutations on multicellularity-related genes. Expression analyses reveal mainly downregulation genes and an evolving expression profile towards embryonic stem cells, cell type resembling unicellular life in its...
Obstructive sleep apnea is a common disorder associated with increased risk for cardiovascular disease, diabetes, and premature mortality. Although there strong clinical epidemiologic evidence supporting the importance of genetic factors in influencing obstructive apnea, its basis still largely unknown. Prior studies focused on traits defined using apnea-hypopnea index, which contains limited information potentially important genetically determined physiologic factors, such as propensity...
Abstract Both short and long sleep are associated with an adverse lipid profile, likely through different biological pathways. To elucidate the biology of sleep-associated we conduct multi-ancestry genome-wide sleep-SNP interaction analyses on three traits (HDL-c, LDL-c triglycerides). In total study sample (discovery + replication) 126,926 individuals from 5 ancestry groups, when considering either or time interactions in joint analyses, identify 49 previously unreported loci, 10 additional...