A5024561283- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Neonatal Respiratory Health Research
- Genetic Associations and Epidemiology
- Respiratory and Cough-Related Research
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- School Health and Nursing Education
- Respiratory viral infections research
- Vitamin D Research Studies
- Breastfeeding Practices and Influences
- Inhalation and Respiratory Drug Delivery
- Child and Adolescent Health
- Obesity, Physical Activity, Diet
- Occupational Health and Performance
- Noise Effects and Management
- Injury Epidemiology and Prevention
- Climate Change and Health Impacts
- Health, psychology, and well-being
- Food Allergy and Anaphylaxis Research
- Dermatology and Skin Diseases
- Gene expression and cancer classification
University of Pittsburgh
2016-2025
Children's Hospital of Pittsburgh
2016-2025
University of Pittsburgh Medical Center
2015-2024
Massachusetts General Hospital
2024
University of Puerto Rico System
2024
Outcomes Research Consortium
2023
Pulmonary Associates
2015-2022
Metropolitan University
2019-2020
St. Francis Hospital
2019
Icahn School of Medicine at Mount Sinai
2019
Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study examined the relationship between measured levels and markers of severity childhood.To determine both allergy childhood.We relation 25-hydroxyvitamin (the major circulating form D) a cross-sectional 616 Costa Rican children ages 6 14 years. Linear, logistic, negative binomial regressions were used for univariate multivariate analyses.Of asthma, 175 (28%) had...
Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly high-risk groups.We tested for an association between single-nucleotide polymorphisms (SNPs) gene encoding matrix metalloproteinase 12 (MMP12) a measure (prebronchodilator forced expiratory volume 1 second [FEV(1)]) more than 8300 subjects seven cohorts that included adults. Within Normative Aging Study (NAS), cohort initially...
Section:ChooseTop of pageAbstract <<EXECUTIVE SUMMARYEPIDEMIOLOGY OF ASTHMA AN...ANIMALS MODELS SUPPORT A ...PATHOGENESIS IN...OBESE ASTHMA: NEW PHENO...CONCLUSIONS AND FUTURE DI...ReferencesCITING ARTICLES
For unclear reasons, obese children with asthma have higher morbidity and reduced response to inhaled corticosteroids.To assess whether childhood obesity is associated airway dysanapsis (an incongruence between the growth of lungs airways) morbidity.We examined relationship in six cohorts without asthma, as well clinical outcomes asthma. Adjusted odds ratios (ORs) were calculated for each cohort a combined analysis all cohorts; longitudinal analyses also performed available data. Hazard...
Author(s): Thakur, Neeta; Lovinsky-Desir, Stephanie; Bime, Christian; Wisnivesky, Juan P; Celedon, C
The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect swabs from the anterior nares 547 children (mean-age 12.9 y), measure DNA methylation (DNAm) with Infinium MethylationEPIC BeadChip. We perform Epigenome-Wide Association analyses (EWAS) current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric oxide (FeNO) lung function. find multiple differentially methylated CpGs (FDR < 0.05) Regions (DMRs; ≥ 5-CpGs...
The rising prevalence of asthma in developed nations may be associated with the obesity these same nations. relationship between body mass index (BMI) and development an objective marker for asthma, methacholine airway hyperresponsiveness (AHR), was investigated adult men.Sixty one men who had no AHR at initial challenge testing but about 4 years later 244 matched controls participated study. effects BMI change on were examined conditional logistic regression models.Initial found to have a...
Although cigarette smoking is the primary environmental risk factor, genetic factors likely influence development of chronic obstructive pulmonary disease (COPD). Linkage analysis between short-tandem repeat markers on chromosome 19 and COPD phenotypes was followed by association single nucleotide polymorphisms in a gene 19q [transforming growth factor-beta1 (TGFB1)] family-based sample case-control study (cases with severe control subjects significant history but no COPD). Stratification...
There is growing international interest in the possible relationships between helminthic infection and allergic disease, although nature of remains uncertain controversial. The interrelationships current past with Ascaris lumbricoides asthma atopy were investigated a cross-sectional sample 2,164 children ages 8 18 years from Anqing Province, China. sampled larger family-based study genetics asthma. prevalence either history or positive stool examination for was 24.5%. Asthma defined analytic...
Rationale: Vitamin D insufficiency (a serum 25(OH)D <30 ng/ml) has been associated with severe asthma exacerbations, but this could be explained by underlying racial ancestry or disease severity. Little is known about vitamin and in Puerto Ricans.Objectives: To examine whether exacerbations Rican children, independently of ancestry, atopy, time outdoors.Methods: A cross-sectional study was conducted 560 children ages 6–14 years (n = 287) without 273) San Juan, Rico. We measured plasma...