A5057830517- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Air Quality and Health Impacts
- Eosinophilic Esophagitis
- Respiratory Support and Mechanisms
- Neonatal Respiratory Health Research
- Noise Effects and Management
- Nitric Oxide and Endothelin Effects
- Vitamin D Research Studies
- Adipose Tissue and Metabolism
- Neuroscience of respiration and sleep
- Pharmaceutical studies and practices
- Allergic Rhinitis and Sensitization
- Sulfur Compounds in Biology
- Climate Change and Health Impacts
- Helicobacter pylori-related gastroenterology studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Obesity, Physical Activity, Diet
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Global Health Care Issues
University of Colorado Denver
2017-2025
University of Colorado Anschutz Medical Campus
2017-2025
RELX Group (United States)
2024
Pulmonary and Critical Care Associates
2023
University of Colorado System
2020-2021
University of Colorado Boulder
2020
University of Pittsburgh
2010-2019
University of Pittsburgh Medical Center
2012-2019
University of Colorado Health
2019
Denver School of Nursing
2019
Chronic obstructive pulmonary disease (COPD) is associated with important chronic comorbid diseases, including cardiovascular disease, diabetes and hypertension. The present study analysed data from 20,296 subjects aged ≥45 yrs at baseline in the Atherosclerosis Risk Communities Study (ARIC) Cardiovascular Health (CHS). sample was stratified based on lung function data, according to modified Global Initiative for Obstructive Lung Disease (GOLD) criteria. Comorbid death hospitalisations over...
This document provides clinical recommendations for the management of severe asthma. Comprehensive evidence syntheses, including meta-analyses, were performed to summarise all available relevant European Respiratory Society/American Thoracic Society Task Force's questions. The was appraised using GRADE (Grading Recommendations, Assessment, Development and Evaluation) approach results summarised in profiles. syntheses discussed formulated by a multidisciplinary Force asthma experts, who made...
Reducing asthma exacerbation frequency is an important criterion for approval of therapies, but the clinical features exacerbation-prone (EPA) remain incompletely defined.To describe clinical, physiologic, inflammatory, and comorbidity factors associated with EPA.Baseline data from NHLBI Severe Asthma Research Program (SARP)-3 were analyzed. An was defined as a burst systemic corticosteroids lasting 3 days or more. Patients classified by their number exacerbations in past year: none, few...
The patterns and outcomes of noninvasive, positive-pressure ventilation (NIPPV) use in patients hospitalized for acute exacerbations chronic obstructive pulmonary disease (COPD) nationwide are unknown.
Severe asthma (SA) is a challenge to control, as patients are not responsive high doses of systemic corticosteroids (CS). In contrast, mild-moderate (MMA) low inhaled CS, indicating that Th2 cells, which dominant in MMA, do solely orchestrate SA development. Here, we analyzed broncholalveolar lavage cells isolated from MMA and determined IFN-γ (Th1) immune responses exacerbated the airways individuals with SA, reduced IL-17 responses. We developed protocol recapitulates complex response...
The association between obesity and asthma severity remains controversial limited to small studies.We determined the of body mass index (BMI) in National Asthma Survey. We included adults (age > or = 18 years) who self-reported symptoms past 5 years. A total 3095 patients were divided into following BMI categories: 1080 (35%) non-overweight (BMI < 25), 993 (32%) overweight 25 30) 1022 (33%) obese 30). measures respiratory symptoms, healthcare utilisation, medication use, missed work days...
Section:ChooseTop of pageAbstract <<EXECUTIVE SUMMARYEPIDEMIOLOGY OF ASTHMA AN...ANIMALS MODELS SUPPORT A ...PATHOGENESIS IN...OBESE ASTHMA: NEW PHENO...CONCLUSIONS AND FUTURE DI...ReferencesCITING ARTICLES
IMPORTANCEIn asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes.It not known if supplementing inhaled corticosteroids oral 3 improves outcomes in patients insufficiency.OBJECTIVE To evaluate supplementation would improve the clinical efficacy of symptomatic lower levels. DESIGN, SETTING, AND PARTICIPANTSThe VIDA (Vitamin Add-on Therapy Enhances Corticosteroid Responsiveness Asthma) randomized, double-blind, parallel, placebo-controlled trial studying adult...
The National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP) has characterized over the past 10 years 1,644 patients with asthma, including 583 individuals severe asthma. SARP collaboration led to a rapid recruitment of subjects efficient sharing samples among participating sites conduct independent mechanistic investigations Enrolled underwent detailed clinical, physiologic, genomic, radiological evaluations. In addition, investigators developed safe procedures for...
<h3>Importance</h3> Many preschool children develop recurrent, severe episodes of lower respiratory tract illness (LRTI). Although viral infections are often present, bacteria may also contribute to pathogenesis. Strategies that effectively attenuate such needed. <h3>Objective</h3> To evaluate if early administration azithromycin, started prior the onset LRTI symptoms, in with recurrent LRTIs can prevent progression these episodes. <h3>Design, Setting, and Participants</h3> A randomized,...
Abstract Background Recently, it has been shown that increasing body mass index (BMI) in asthma is associated with reduced exhaled NO. Our objective this study was to determine if the BMI-related changes NO differ across asthmatics and controls, these are related increased airway oxidative stress systemic levels of leptin adiponectin. Methods Observational association BMI, leptin, adiponectin nitric oxide (NO) 8-isoprostanes 67 non-smoking patients moderate severe persistent during baseline...
Increasing body mass index (BMI) has been associated with less fractional exhaled nitric oxide (Fe(NO)). This may be explained by an increase in the concentration of asymmetric dimethyl arginine (ADMA) relative to L-arginine, which can lead greater synthase uncoupling.To compare this mechanism across age asthma onset groups and determine its association morbidity lung function.Cross-sectional study participants from Severe Asthma Research Program, early- (<12 yr) late- (>12...