Dawn L. DeMeo
A5051093934- Chronic Obstructive Pulmonary Disease (COPD) Research
- Epigenetics and DNA Methylation
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Genetic Associations and Epidemiology
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Birth, Development, and Health
- Bioinformatics and Genomic Networks
- Gene expression and cancer classification
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Air Quality and Health Impacts
- Delphi Technique in Research
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Pharmacogenetics and Drug Metabolism
- Protease and Inhibitor Mechanisms
- Cancer-related gene regulation
- Genomics and Rare Diseases
- Health, Environment, Cognitive Aging
- Genetic Mapping and Diversity in Plants and Animals
- Hormonal Regulation and Hypertension
- Gene Regulatory Network Analysis
Brigham and Women's Hospital
2016-2025
Harvard University
2016-2025
Harvard University Press
2012-2024
Woman's Hospital
2023-2024
Boston University
2006-2022
VA Boston Healthcare System
2022
Harvard Pilgrim Health Care
2022
Beth Israel Deaconess Medical Center
2004-2021
Washington University in St. Louis
2020
Pulmonary and Critical Care Associates
2011-2018
Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate the genetic architecture and biology of heart, lung, blood sleep disorders, with ultimate goal improving diagnosis, treatment prevention these diseases. initial phases focused on whole-genome sequencing individuals rich phenotypic data diverse backgrounds. Here we describe TOPMed goals design as well available resources early insights obtained from sequence data. include a variant browser, genotype...
In December 2003 and April 2005, signs symptoms suggestive of infection developed in two groups recipients solid-organ transplants. Each cluster was investigated because diagnostic evaluations were unrevealing, each a common donor recognized.
<h3>Importance</h3> Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow may assume that they are free. <h3>Objective</h3> To identify clinical radiologic evidence of smoking-related in a cohort who did not meet spirometric criteria for COPD, whom we adopted the discarded label Global Initiative Obstructive Lung Disease (GOLD) 0. <h3>Design, Setting, Participants</h3> Individuals from...
Although all human tissues carry out common processes, are distinguished by gene expression patterns, implying that distinct regulatory programs control tissue specificity. In this study, we investigate and regulation across 38 profiled in the Genotype-Tissue Expression project. We find network edges (transcription factor to target connections) have higher specificity than nodes (genes) regulating factors) less likely be expressed a tissue-specific manner as compared their targets (genes)....
Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly high-risk groups.We tested for an association between single-nucleotide polymorphisms (SNPs) gene encoding matrix metalloproteinase 12 (MMP12) a measure (prebronchodilator forced expiratory volume 1 second [FEV(1)]) more than 8300 subjects seven cohorts that included adults. Within Normative Aging Study (NAS), cohort initially...
Sex differences manifest in many diseases and may drive sex-specific therapeutic responses. To understand the molecular basis of sex differences, we evaluated sex-biased gene regulation by constructing sample-specific regulatory networks 29 human healthy tissues using 8,279 whole-genome expression profiles from Genotype-Tissue Expression (GTEx) project. We find network structures each tissue. Even though most transcription factors (TFs) are not differentially expressed between males females,...
The number of female smokers developing chronic obstructive pulmonary disease (COPD) is rapidly increasing, but whether or not there exists a differential susceptibility by gender remains controversial.How smoking behaviour and subsequent lung function reduction differed was examined in study including 954 subjects with COPD 955 without COPD. focused on two subgroups: <60 years age (early-onset group, n=316) <20 pack-years (low exposure n=241).In the low had lower forced expiratory volume 1...
The impact of cigarette smoking can persist for extended periods following cessation and may involve epigenetic reprogramming. Changes in DNA methylation associated with help to identify molecular pathways that contribute the latency between exposure disease onset. Cross-sectional cohort data from subjects International COPD Genetics Network (n = 1085) Boston Early-Onset study 369) were analyzed as discovery replication cohorts, respectively. Genome-wide on 27 578 CpG sites 14 475 genes...
Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of preserved FEV1/FVC ratio, is highly prevalent and associated with increased respiratory symptoms, systemic inflammation, mortality. Studies investigating quantitative chest tomographic features, genetic associations, subtypes PRISm subjects have not been reported. Data from current former smokers enrolled COPDGene (n = 10,192), an observational, cross-sectional study which recruited aged 45–80 ≥10 pack...
Summary paragraph The Trans-Omics for Precision Medicine (TOPMed) program seeks to elucidate the genetic architecture and disease biology of heart, lung, blood, sleep disorders, with ultimate goal improving diagnosis, treatment, prevention. initial phases focus on whole genome sequencing individuals rich phenotypic data diverse backgrounds. Here, we describe TOPMed goals design as well resources early insights from sequence data. include a variant browser, genotype imputation panel, sharing...
Increasing awareness of the prevalence and significance Preserved Ratio Impaired Spirometry (PRISm), alternatively known as restrictive or Global Initiative for Chronic Obstructive Lung Disease (GOLD)-unclassified spirometry, has expanded body knowledge on cross-sectional risk factors. However, longitudinal studies PRISm remain limited.
Growing evidence has linked positive psychological attributes like optimism to a lower risk of poor health outcomes, especially cardiovascular disease. It been demonstrated in randomized trials that can be learned. If associations between and broader outcomes are established, it may lead novel interventions improve public longevity. In the present study, we evaluated association cause-specific mortality women after considering role potential confounding (sociodemographic characteristics,...
Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified substantial number individuals without COPD who suffer from respiratory symptoms and/or increased There is clear need for an expanded definition that linked to physiologic, structural (computed tomography [CT]) clinical disease. Using data the Genetic Epidemiology study (COPDGene