A5007492962- Air Quality and Health Impacts
- Asthma and respiratory diseases
- Noise Effects and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Epigenetics and DNA Methylation
- Environmental Justice and Health Disparities
- Urban Transport and Accessibility
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Global Health Workforce Issues
- Respiratory Support and Mechanisms
- Respiratory and Cough-Related Research
- COVID-19 Clinical Research Studies
- School Health and Nursing Education
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Diversity and Career in Medicine
- Hemoglobinopathies and Related Disorders
- Indoor Air Quality and Microbial Exposure
- Immune Cell Function and Interaction
- Prenatal Screening and Diagnostics
- Genetic Syndromes and Imprinting
- Effects and risks of endocrine disrupting chemicals
- Medical Education and Admissions
Columbia University
2015-2024
Columbia University Irving Medical Center
2017-2024
Icahn School of Medicine at Mount Sinai
2024
University of California, San Francisco
2023
Columbia College
2022
Royal College of Physicians
2022
Presbyterian Hospital
2020
Bangladesh College of Physicians and Surgeons
2020
New York Hospital Queens
2018
NewYork–Presbyterian Hospital
2012-2018
Author(s): Thakur, Neeta; Lovinsky-Desir, Stephanie; Bime, Christian; Wisnivesky, Juan P; Celedon, C
Current American Thoracic Society (ATS) standards promote the use of race and ethnicity-specific reference equations for pulmonary function test (PFT) interpretation. There is rising concern that ethnicity in PFT interpretation contributes to a false view fixed differences between races may mask effects differential exposures. This contribute health disparities by norming function. In United States globally, serves as social construct based on appearance reflects values, structures,...
BackgroundAsthma prevalence and severity have markedly increased with urbanisation, children in low-income urban centres among the greatest asthma morbidity. Outdoor air pollution has been associated adverse respiratory effects asthma. However, mechanisms by which exposure exacerbates asthma, how these compare exacerbations induced viruses, are poorly understood. We aimed to investigate associations between regional pollutant concentrations, illnesses, lung function, upper airway...
Background: Well-designed clinical research needs to obtain information that is applicable the general population. However, most current studies fail include substantial cohorts of racial/ethnic minority populations. Such underrepresentation may lead delayed diagnosis or misdiagnosis disease, wide application approved interventions without appropriate knowledge their usefulness in certain populations, and development recommendations are not broadly applicable.Goals: To develop best practices...
BackgroundChildhood maltreatment is associated with adverse health outcomes and this risk can be transmitted to the next generation. We aimed investigate association between exposure maternal childhood common physical mental problems, neurodevelopmental disorders, related comorbidity patterns in offspring.Methods.We conducted a retrospective cohort study using data from Environmental influences on Child Health Outcomes (ECHO) Program, which was launched influence of early life exposures...
Respiratory symptoms are ubiquitous in children and, even though they may be the harbinger of poor long-term outcomes, often trivialised. Adverse exposures pre-conception, antenatally and early childhood have lifetime impacts on respiratory health. For most part, lung function tracks from pre-school years at least into late middle age, airflow obstruction is associated not merely with outcomes but also all-cause morbidity mortality. Much would preventable if social determinants adverse were...
Both short and long-term exposure to traffic-related air pollutants have been associated with asthma reduced lung function. We hypothesized that short-term indoor fine particulate matter <2.5 μm (PM2.5) vanadium (V) would be altered buccal cell DNA methylation of targeted genes decreased function among urban children in a nested subcohort African American Dominican children. Six day integrated levels were measured from children's homes (age 9–14; n = 163), repeated 6 months later (n 98)....
Asthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, temporality and individual susceptibility to environmental epigenetic regulation asthma has not been fully elucidated. Our objective was determine timeline black carbon (BC) exposure, measured by personal sampling, allergic genes 5 days later capture usual weather variations differences related changes in behavior activities. We also sought how vary seroatopy cockroach sensitization...
In the 1930's United States (US) sponsored Home Owners' Loan Corporation (HOLC) created maps that determined risk for mortgage lending based on racial and ethnic composition of neighborhoods leading to disinvestment in "redlined" or highest neighborhoods. This historical practice has perpetuated economic segregation, health disparities, persist today. Interventions near schools where children spend large portions day, could impact groups but are an often-overlooked environment exposure....
Physical activity is associated with improvement in lung function; however, pollution exposure during physical can lead to a transient reduction function. This paradoxical relationship may be linked altered T regulatory (Treg) cell activity, which increases exercise and suppresses airway inflammation, but decreases association air pollution. To clarify these relationships, we investigated buccal DNA methylation of the forkhead box p3 (FOXP3) gene promoter, proposed biomarker Treg activity....
To address the lack of guidance for clinicians in their care children with critical asthma, a multidisciplinary team medical providers used Grading Recommendations, Assessment, Development, and Evaluation methodology to make following recommendations: 1. We suggest use continuous inhaled short-acting β agonist (SABA) over frequent intermittent SABA treated asthma. (Conditional recommendation, very low certainty evidence) 2. either high- or low-dose regimens 3. dexamethasone...
Asthma is associated with allergic sensitization in about half of all cases, and asthma phenotypes can vary by age sex. DNA methylation the promoter allergy regulatory gene interferon gamma (IFNγ) has been linked to maintenance immune function human cell mouse models. We hypothesized that IFNγ at two well-studied, key cytosine phosphate guanine (CpG) sites (-186 -54), may differ age, sex, airway versus systemic tissue a cohort 74 asthmatics. After sampling buccal cells, surrogate for...
Epigenetic architecture is influenced by genetic and environmental factors, but little known about their relative contributions or longitudinal dynamics. Here, we studied DNA methylation (DNAm) at over 750,000 CpG sites in mononuclear blood cells collected birth age 7 from 196 children of primarily self-reported Black Hispanic ethnicities to study race-associated DNAm patterns. We developed a novel Bayesian method for high-dimensional data showed that patterns are nearly identical....
Abstract Childhood asthma exacerbation remains the leading cause of pediatric emergency department visits and hospitalizations disproportionately affects Latinx Black children, compared to non-Latinx White children in NYC. Environmental exposures socioeconomic factors may jointly contribute childhood exacerbations; however, they are often studied separately. To better investigate multiple contributors disparities asthma, we compiled data on various individual neighborhood level environmental...