A5074833807- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Heavy Metal Exposure and Toxicity
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Child Nutrition and Water Access
- Per- and polyfluoroalkyl substances research
- Neonatal Respiratory Health Research
- Arsenic contamination and mitigation
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Energy and Environment Impacts
- Effects and risks of endocrine disrupting chemicals
- Pregnancy and Medication Impact
- Climate Change and Health Impacts
- Trace Elements in Health
- Childhood Cancer Survivors' Quality of Life
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- RNA modifications and cancer
- Toxic Organic Pollutants Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Adolescent and Pediatric Healthcare
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Carcinogens and Genotoxicity Assessment
Stanford Medicine
2023-2025
Stanford University
2022-2025
Palo Alto University
2023-2025
Hospital Universitario Infantil San José
2025
University of California, Berkeley
2019-2023
Center for Environmental Health
2021-2022
Harvard University
2016-2022
Berkeley Public Health Division
2019-2022
Harvard Pilgrim Health Care
2016-2022
Brigham and Women's Hospital
2022
The nasal cellular epigenome may serve as biomarker of airway disease and environmental response. Here we collect swabs from the anterior nares 547 children (mean-age 12.9 y), measure DNA methylation (DNAm) with Infinium MethylationEPIC BeadChip. We perform Epigenome-Wide Association analyses (EWAS) current asthma, allergen sensitization, allergic rhinitis, fractional exhaled nitric oxide (FeNO) lung function. find multiple differentially methylated CpGs (FDR < 0.05) Regions (DMRs; ≥ 5-CpGs...
Abstract Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present fatigue and multi-system disorders, are often lean, die prematurely, but the mechanistic basis for this clinical picture remains unclear. By integrating data from 17 cohorts of patients diseases ( n = 690) we find evidence that these disorders increase resting energy expenditure, a state termed hypermetabolism . We examine phenomenon longitudinally in patient-derived fibroblasts multiple donors....
Prenatal arsenic exposure is associated with increased risk of disease in adulthood. This has led to considerable interest arsenic's ability disrupt fetal programming. Many studies report that alters DNA methylation whole blood but these did not adjust for cell mixture. In this study, we examined the relationship between maternal drinking water collected ≤ 16 weeks gestational age and cord (n = 44) adjusting leukocyte-tagged differentially methylated regions. was quantified using Infinium...
Mercury and arsenic are known developmental toxicants. Prenatal exposures associated with adverse childhood health outcomes that could be in part mediated by epigenetic alterations may also contribute to altered immune profiles. In this study, we examined the association between prenatal mercury exposure on both DNA methylation white blood cell composition of cord blood, evaluated interaction exposure. A total 138 mother-infant pairs postpartum maternal toenail mercury, urinary...
Prenatal exposure to mercury, a known neurotoxic metal, is associated with lower cognitive performance during childhood. Disruption of fetal epigenetic programming could explain mercury's neurodevelopmental effects. We screened for epigenome-wide methylation differences maternal prenatal blood mercury levels in 321 cord DNA samples and examined the persistence these alterations early (n = 75; 2.9-4.9 years) mid-childhood 291; 6.7-10.5 years). Among males, were regional at Paraoxonase 1 gene...
Background: Several per- and polyfluoroalkyl substances (PFAS) are ubiquitous anthropogenic pollutants almost universally detected in humans. Experimental evidence indicates that PFAS alter glucose metabolism insulin secretion. However, epidemiological studies have yielded inconsistent results. Objective: We sought to examine associations between plasma concentrations, glycemic indicators, diabetes incidence among high-risk adults. Methods: Within the Diabetes Prevention Program (DPP), a...
Exposure to per- and polyfluoroalkyl substances (PFASs) may interfere with lipid regulation. However, most previous studies were cross-sectional the risk of reverse causation, suggesting a need for long-term prospective studies. We examined relationship baseline plasma PFAS concentrations repeated measures blood lipids. included 888 prediabetic adults from Diabetes Prevention Program (DPP) DPP Outcomes Study, who had measurements 6 at (1996–1999) lipids over 15 years follow-up, initially...
Children are exposed to flame retardants from the built environment. Brominated diphenyl ethers (BDE) and organophosphate-based (OPFRs) associated with poorer neurocognitive functioning in children. Less is known, however, about association between these classes of compounds children's emotional social behaviors. The objective this study was determine if retardant exposure measurable differences behaviors among children ages 3–5 years. We examined teacher-rated measured using Social Skills...
Abstract The key characteristics (KC) of human carcinogens provide a uniform approach to evaluating mechanistic evidence in cancer hazard identification. Refinements the were requested by organizations and individuals applying KCs. We assembled an expert committee with knowledge carcinogenesis experience KCs leveraged this expertise examined literature more clearly describe each KC, identify current emerging assays vivo biomarkers that can be used measure them, make recommendations for...
Metal exposure during pregnancy influences maternal and child health. Oxidative stress inflammation may mediate adverse effects of heavy metals, whereas essential metals act as antioxidants. Mitochondrial DNA is a prime target for metal-induced oxidative damage. Telomere dysfunction attributed to imbalances between reactive oxidant species antioxidants.We evaluated individual joint associations prenatal with mitochondrial copy number (mtDNAcn) telomere length (TL) in cord blood biomarkers...
Abstract Background Epigenetic age acceleration (EAA) and epigenetic gestational (EGAA) are biomarkers of physiological development may be affected by the perinatal environment. The aim this study was to evaluate performance clocks identify biological sociodemographic correlates EGAA EAA at birth in childhood. In Project Viva pre-birth cohort, DNA methylation measured nucleated cells cord blood (leukocytes red cells, N = 485) leukocytes early (N 120, median 3.2 years) mid-childhood 460, 7.7...
Importance Preeclampsia, gestational hypertension, and diabetes, the most common pregnancy complications, are associated with substantial morbidity mortality in mothers children. Little is known about biological processes that link occurrence of these complications adverse child outcomes; altered aging growing fetus up to birth one molecular pathway increasing interest. Objective To evaluate whether exposure each 3 (gestational preeclampsia) accelerated or decelerated age children at birth....
Importance Prenatal perfluoroalkyl and polyfluoroalkyl substances (PFAS) have been linked to adverse birth outcomes. Previous research showed that higher folate concentrations are associated with lower blood PFAS in adolescents adults. Further studies needed explore whether prenatal status mitigates PFAS-related Objective To examine modifies the negative associations between pregnancy concentrations, weight, gestational age previously observed a US cohort. Design, Setting, Participants In...
Background: Early-life exposure to lead is associated with deficits in neurodevelopment and hematopoietic system toxicity. DNA methylation may be one of the underlying mechanisms for adverse effects prenatal on offspring, but epigenome-wide data low levels are lacking. Objectives: We investigated association between maternal umbilical cord blood nucleated cells Project Viva, a prospective U.S.-based prebirth cohort relatively exposure. Methods: Among 268 mother–infant pairs, we measured...
Background: the relationship between arsenic and birth weight is not well understood.the objective was to evaluate causal prenatal exposure considering potential mediation effects of gestational age maternal gain during pregnancy using structural equation models.Methods: a prospectively enrolled cohort pregnant women recruited in Bangladesh from 2008 2011.arsenic measured personal drinking water at time enrollment (gestational <16 weeks, n = 1,140) toenails collected ≤1 month postpartum (n...
<h3>Importance</h3> Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are ubiquitous synthetic chemicals that suspected endocrine disruptors. <h3>Objectives</h3> To determine the extent to which PFASs associated with increases in weight body size evaluate whether a lifestyle intervention modifies this association. <h3>Design, Setting, Participants</h3> This prospective cohort study included 957 individuals who participated Diabetes Prevention Program trial, conducted from July 1996 May...
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are suspected endocrine disruptors widely detected across populations. We examine the extent to which PFASs associated with diabetes incidence microvascular disease. Secondarily, we tested whether a lifestyle intervention modifies associations decreases concentrations.
Background: Mercury is a global pollutant, and prenatal exposure associated with adverse health effects. To date, no studies have evaluated the association between mercury DNA hydroxymethylation, an epigenetic modification important for tissue differentiation embryonic development. Objectives: We sought to evaluate offspring methylation hydroxymethylation at birth test persistence of in childhood. Methods: Within Project Viva, U.S. prebirth cohort, we examined associations maternal second...
Maternal mood disorders and their treatment during pregnancy may have effects on the offspring epigenome. We aim to evaluate associations of maternal prenatal antidepressant use, anxiety, depression with cord blood DNA methylation across genome at birth test for persistence in early mid-childhood DNA. A discovery phase was conducted Project Viva, a prospective pre-birth cohort study external replication an independent cohort, Generation R Study. In pregnant women were recruited between 1999...