A5041410391- Birth, Development, and Health
- Obesity, Physical Activity, Diet
- Gestational Diabetes Research and Management
- Nutritional Studies and Diet
- Diet and metabolism studies
- Epigenetics and DNA Methylation
- Pregnancy and preeclampsia studies
- Health, Environment, Cognitive Aging
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Effects and risks of endocrine disrupting chemicals
- Child Nutrition and Water Access
- Breastfeeding Practices and Influences
- Cardiovascular Health and Risk Factors
- Air Quality and Health Impacts
- Pancreatic function and diabetes
- Nutrition, Genetics, and Disease
- Diabetes Management and Research
- Bariatric Surgery and Outcomes
- Diabetes and associated disorders
- Per- and polyfluoroalkyl substances research
- Maternal Mental Health During Pregnancy and Postpartum
University of Colorado Anschutz Medical Campus
2019-2025
Colorado School of Public Health
2018-2025
University of Colorado Denver
2019-2024
University of Michigan–Ann Arbor
2015-2024
Cohort (United Kingdom)
2024
University of Colorado Health
2023
The Medical Center of Aurora
2020-2021
University of Colorado System
2019
Atkins (United States)
2019
National Institute of Public Health
2019
Objective To identify metabolite patterns associated with childhood obesity, to examine relations of these measures adiposity and cardiometabolic risk, evaluate associations maternal peripartum characteristics. Methods Untargeted metabolomic profiling was used quantify metabolites in plasma 262 children (6-10 years). Principal components analysis consolidate 345 into 18 factors identified two that differed between obese (BMI ≥ 95‰; n = 84) lean < 85‰; 150). The (fat mass, BMI, skinfold...
Purpose The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother–child pregnancy and birth cohort originally initiated the mid-1990s explore: (1) whether enhanced mobilisation of lead from maternal bone stores during poses risk fetal subsequent offspring neurodevelopment; (2) calcium supplementation lactation can suppress mitigate adverse effects exposure on health development. Through utilisation carefully archived biospecimens measure other prenatal...
A goal of many research programmes in biology is to extract meaningful insights from large, complex datasets. Researchers ecology, evolution and behavior (EEB) often grapple with long-term, observational datasets which they construct models test causal hypotheses about biological processes. Similarly, epidemiologists analyse understand the distribution determinants human health. key difference analytical workflows for these two distinct areas delineation data analysis tasks explicit use...
Importance Physical and social neighborhood attributes may have implications for children’s growth development patterns. The extent to which these are associated with body mass index (BMI) trajectories obesity risk from childhood adolescence remains understudied. Objective To examine associations of neighborhood-level measures opportunity vulnerability BMI birth adolescence. Design, Setting, Participants This cohort study used data 54 cohorts (20 677 children) participating in the...
Hypertensive disorders of pregnancy (HDP), defined here as hypertensive with onset in (i.e., gestational hypertension, preeclampsia, and preeclampsia superimposed on chronic hypertension), affect up to 10% pregnancies the United States are associated substantial maternal neonatal morbidity mortality. Per- polyfluoroalkyl substances (PFAS) adverse cardiometabolic outcomes during pregnancy, but associations between PFAS HDP inconsistent joint effects mixtures have not been evaluated. We...
Abstract Background Epigenetic age acceleration (EAA) and epigenetic gestational (EGAA) are biomarkers of physiological development may be affected by the perinatal environment. The aim this study was to evaluate performance clocks identify biological sociodemographic correlates EGAA EAA at birth in childhood. In Project Viva pre-birth cohort, DNA methylation measured nucleated cells cord blood (leukocytes red cells, N = 485) leukocytes early (N 120, median 3.2 years) mid-childhood 460, 7.7...
Globally, childhood obesity is on the rise and effect of objectively measured movement behaviour body composition remains unclear. Longitudinal causal mediation relationships accelerometer-based sedentary time (ST), light physical activity (LPA), moderate-to-vigorous (MVPA) with dual-energy X-ray absorptiometry-measured fat mass were examined in 6059 children aged 11 years followed-up until age 24 from Avon Study Parents Children (ALSPAC), UK birth cohort. Over 13-year follow-up, each...
In recent years, the prevalence of hypertension and prehypertension increased markedly among children adolescents, highlighting importance identifying determinants elevated blood pressure early in life. Low birth weight rapid childhood gain are associated with higher future pressure. However, few studies have examined timing postnatal relation to later pressure, little is known regarding contribution linear growth. We studied 957 participants Project Viva, an ongoing US prebirth cohort....
Maternal pre-pregnancy obesity is associated with offspring obesity. Underlying mechanisms may involve a maternal obesity-mediated proinflammatory state during pregnancy. C-reactive protein (CRP) level pregnancy biomarker of low-grade systemic inflammation.Among 1,116 mother-child pairs, this study examined associations second-trimester CRP plasma level, measured by high-sensitivity arrays, mid-childhood DXA fat mass index (FMI), trunk (trunkFMI), fat-free (FFMI), and early BMI-z waist...
Snacking has been related to increased prevalence of overweight among school-age children in cross-sectional studies. It is uncertain, however, whether snacking influences the development adiposity over time.We examined adherence a dietary pattern was associated with greater increases children's BMI, subscapular:triceps skinfold thickness ratio and waist circumference median 2·5-year follow-up. Dietary patterns were identified through principal component analysis an FFQ administered at...
Summary Background Prenatal exposure to traffic pollution has been associated with faster infant weight gain, but implications for cardiometabolic health in later childhood are unknown. Methods Among 1418 children Project Viva, a Boston‐area pre‐birth cohort, we assessed anthropometric and biochemical parameters of early (median age 3.3 years) mid‐ 7.7 childhood. We used spatiotemporal models estimate prenatal life residential PM 2.5 black carbon as well density roadway proximity. performed...
Overweight and obesity (OW/OB) impact half of the pregnancies in United States can have negative consequences for offspring health. Studies are limited on human milk alterations context maternal obesity. Alterations hypothesized to development during critical period lactation. We aimed evaluate relationships between mothers with OW/OB (body mass index [BMI] ≥25 kg/m
Earlier pubertal onset may be associated with an increased risk of chronic diseases. However, the extent to which growth in first 5 years life-an important developmental life stage that lays foundation for later health outcomes-is remains understudied.
Abstract Background Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic in gestational and chronological age determination. Results Our study used data from seven tissue types on three DNA methylation profiling microarrays found that Knight Bohlin performed similarly blood cells, while Lee clock was superior placental samples. The pediatric-buccal-epigenetic best buccal samples, Horvath is recommended children's cell NeoAge...
The extent to which physical and social attributes of neighborhoods play a role in childhood asthma remains understudied. To examine associations neighborhood-level opportunity vulnerability measures with incidence. This cohort study used data from children 46 cohorts participating the Environmental Influences on Child Health Outcomes (ECHO) Program between January 1, 1995, August 31, 2022. Participant inclusion required at least 1 geocoded residential address birth parent or caregiver...