A5082746757- Obesity, Physical Activity, Diet
- Heavy Metal Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Nutritional Studies and Diet
- Child Nutrition and Water Access
- Food Security and Health in Diverse Populations
- Health, Environment, Cognitive Aging
- Health and Lifestyle Studies
- Child Nutrition and Feeding Issues
- Fluoride Effects and Removal
- Eating Disorders and Behaviors
- Sleep and related disorders
- Trace Elements in Health
- Epigenetics and DNA Methylation
- Mercury impact and mitigation studies
- Breastfeeding Practices and Influences
- Obesity and Health Practices
- Diet and metabolism studies
- Early Childhood Education and Development
- Behavioral Health and Interventions
- Air Quality and Health Impacts
- Diet, Metabolism, and Disease
- Gestational Diabetes Research and Management
- Consumer Attitudes and Food Labeling
University of Michigan
2016-2025
Michigan United
2013-2024
Ann Arbor Center for Independent Living
2012-2024
Cambridge University Press
2021
New York University Press
2021
Girls Incorporated
2019
Phoenix Children's Hospital
2019
Harvard University
2008-2018
Nutrition Sciences (Belgium)
2016
Massachusetts Department of Public Health
1990-2014
To evaluate the impact of a school-based health behavior intervention known as Planet Health on obesity among boys and girls in grades 6 to 8.Randomized, controlled field trial with 5 control schools. Outcomes were assessed using preintervention (fall 1995) follow-up measures (spring 1997), including prevalence, incidence, remission obesity.A group 1295 ethnically diverse grade 7 students from public schools 4 Massachusetts communities.Students participated interdisciplinary over 2 school...
Intracellular vesicles destined to fuse with the plasma membrane and secrete their contents must have a mechanism for specifically interacting appropriate target membrane. Such is now suggested by demonstration of specific interaction between vesicular proteins proteins. The vesicle-associated (VAMPs) 1 2 bind acceptor syntaxin 1A 4 but not or 3. binding site within amino acids 194 267 1A, approximate equilibrium dissociation constant 4.7 × 10 -6 molar. These data suggest physical basis...
To evaluate the impact of a school-based interdisciplinary health behavior intervention on diet and physical activity among children in grades 4 5.A quasiexperimental field trial with 6 8 matched control schools. Outcomes were assessed longitudinally using preintervention (fall 1995) follow-up (spring 1997) student survey food frequency measures 24-hour recall activity. Change was also yearly repeated cross-sectional surveys all grade 5 students from 1995 through 1997.Longitudinal data...
<h3>Objectives</h3> To test whether increased television viewing is associated with total energy intake and consumption of foods commonly advertised on television, to these mediates the relationship between intake. <h3>Design</h3> Prospective observational study baseline (fall 1995) follow-up (spring 1997) measures youth diet, physical activity, viewing. We used food advertising data identify 6 groups for (sweet baked snacks, candy, fried potatoes, main courses served as fast food, salty...
Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures exposure, addressed impact prenatal exposures or involved more than 100 participants.Our aim was estimate association exposure with offspring neurocognitive development.We studied participants from Early Life Exposures in Mexico Environmental Toxicants (ELEMENT) project. An ion-selective electrode technique used measure archived urine samples...
Factors predicting the early institutionalization of demented patients were studied in 143 outpatients using univariate and multivariate life-table methods. Four types factors evaluated for prognostic value: severity functional impairment, behavioral disorders, individual patient characteristics, type caregiver. After follow-up 19 ± 12 months, 51 had been institutionalized. Increased global dementia, presence troublesome disruptive behaviors, incontinence increased likelihood...
Background. National data indicate that children and youth do not meet Healthy People 2010 objectives for fruit vegetable intake. Television viewing is hypothesized as a contributing factor because of its documented role in encouraging consumption highly advertised foods may lead to the replacement fruits vegetables. Methods. A sample 548 ethnically diverse students (average age: 11.7 ± 0.8 years) from public schools 4 Massachusetts communities were studied prospectively over 19-month period...
Synaptic vesicle protein 2 (SV2) is a membrane glycoprotein specifically localized to secretory vesicles in neurons and endocrine cells. As first step toward understanding the function of SV2 neural secretion, rat brain complementary DNA (cDNA) that encodes was isolated characterized. Analyses this cDNA predict contains 12 transmembrane domains. The NH -terminal half shows significant amino acid sequence identity family bacterial proteins transport sugars, citrate, drugs. Expression COS...
Objectives. Birth weight predicts infant survival, growth, and development. Previous research suggests that low levels of fetal lead exposure, as estimated by umbilical cord blood-lead at birth, may have an adverse effect on birth weight. This report examines the relationship in blood maternal bone to Methods. Umbilical venous samples anthropometric sociodemographic data were obtained delivery 1-month postpartum. Blood-lead analyzed atomic absorption spectrophotometry. Maternal tibia patella...
We report on the results of Treatwell 5-a-Day study, a worksite intervention aimed at increasing consumption fruits and vegetables.Twenty-two worksites were randomly assigned to 3 groups: (1) minimal control group, (2) intervention, (3) worksite-plus-family intervention. The interventions used community-organizing strategies structured target multiple levels influence, following socioecological model. Data collected by self-administered employee surveys before after intervention; response...
The exocyst is a protein complex required for the late stages of secretion in yeast. Unlike SNAREs (SNAP receptors), important secretory proteins that are broadly distributed on target membrane, specifically located at sites vesicle fusion. We have isolated cDNAs encoding rexo70, rsec5, and rsec15 subunits mammalian complex. amino acid sequences encoded by these genes between 21% 24% identical to their yeast homologs. All three expressed multiple transcripts observed rexo70 rsec15....
Molecular cloning of a cDNA encoding synaptic vesicle protein 2 (SV2) revealed that it is homologous to family proton cotransporters from bacteria and fungi related glucose transporters found in mammals. The similarity raised the possibility SV2 might mediate uptake neurotransmitters into vesicles, an activity known require gradient. To determine whether member vesicular proteins, we used clone screen for similar cDNAs rat brain. We characterized 42 clones, 25 which encode 4 protein, SV2B,...
Abstract Objectives : We examined the relationship between comprehensive fitness tests and overweight using a school surveillance system in racially diverse city United States. Research Methods Procedures Trained physical education teachers measured weight, height, annually from 2001 to 2003. compiled data for cross‐sectional analysis (11, 845 measurements on 6297 students, 5 to14 years of age) 1‐year prospective (4215 2927 students not at baseline, 13 age). Overweight was defined as BMI...
As more U.S. children grow up in Latino families, understanding how social class, culture, and environment influence feeding practices is key to preventing obesity. The authors conducted six focus groups 20 in-depth interviews among immigrant, low-income Latina mothers the Northeast United States classified 17 emergent themes from content analysis according ecologic frameworks for behavior change. Respondents related environmental influences child feeding, diet, activity, namely, supermarket...
Abstract Objective: To examine overweight trends over a 22‐year period among preschool‐aged children from primarily middle‐income families enrolled in health maintenance organization. Research Methods and Procedures: From well‐child care visits to Massachusetts organization, we randomly selected one visit per child calendar year, yielding study sample of 120,680 seen at 366,109 1980 through 2001. Using multivariate logistic regression models accounting for repeated observations individual...
Prenatal lead exposure is associated with deficits in fetal growth and neurodevelopment. Calcium supplementation may attenuate by inhibiting mobilization of maternal bone and/or intestinal absorption ingested lead.Our goal was to evaluate the effect 1,200 mg dietary calcium on blood levels during pregnancy.In a double-blind, randomized, placebo-controlled trial conducted from 2001 through 2003 Mexico City, we randomly assigned 670 women their first trimester pregnancy ingest (n = 334) or...