A5089429080- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Environmental Toxicology and Ecotoxicology
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Marine animal studies overview
- Recycling and Waste Management Techniques
- Effects and risks of endocrine disrupting chemicals
- Municipal Solid Waste Management
- Mining and Resource Management
- Heavy metals in environment
- Pharmaceutical and Antibiotic Environmental Impacts
- Healthcare and Environmental Waste Management
- Energy and Environment Impacts
- Gene expression and cancer classification
- Fluoride Effects and Removal
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Environmental Justice and Health Disparities
- Bioinformatics and Genomic Networks
- Microplastics and Plastic Pollution
- Epigenetics and DNA Methylation
- Animal testing and alternatives
- Nutritional Studies and Diet
- Physiological and biochemical adaptations
McGill University
2016-2025
University of Michigan–Ann Arbor
2014-2024
University of Pittsburgh
2024
University of Ghana
2020-2022
Vrije Universiteit Amsterdam
2021
Bellevue Hospital Center
2020
Bahir Dar University
2020
Thomas College
2020
Ann Arbor Center for Independent Living
2019
Assembly of First Nations
2012
The growing application of gene expression profiling demands powerful yet user-friendly bioinformatics tools to support systems-level data understanding. NetworkAnalyst was first released in 2014 address the key need for interpreting within context protein-protein interaction (PPI) networks. It soon updated meta-analysis with improved workflow and performance. Over years, has been continuously based on community feedback technology progresses. Users can now perform 17 different species. In...
Environmental mercury (Hg) contamination is an urgent global health threat. The complexity of Hg in the environment can hinder accurate determination ecological and human risks, particularly within context rapid changes that are altering many processes, socioeconomic patterns, other factors like infectious disease incidence, which affect exposures outcomes. However, success Hg-reduction efforts depends on assessments their effectiveness reducing risks. In this paper, we examine role key...
Since the last Arctic Monitoring and Assessment Programme (AMAP) effort to review biological effects of exposure organohalogen compounds (OHCs) in biota, there has been a considerable number new effect studies. Here, we provide an update on state knowledge OHC, also include mercury, and/or associated key marine terrestrial mammal bird species as well fish by reviewing literature published since AMAP assessment 2010. We aimed at updating how single but combined health are or can be mixtures...
Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures exposure, addressed impact prenatal exposures or involved more than 100 participants.Our aim was estimate association exposure with offspring neurocognitive development.We studied participants from Early Life Exposures in Mexico Environmental Toxicants (ELEMENT) project. An ion-selective electrode technique used measure archived urine samples...
Abstract The increasing application of RNA sequencing to study non-model species demands easy-to-use and efficient bioinformatics tools help researchers quickly uncover biological functional insights. We developed ExpressAnalyst ( www.expressanalyst.ca ), a web-based platform for processing, analyzing, interpreting RNA-sequencing data from any eukaryotic species. contains series modules that cover processing annotation FASTQ files statistical analysis count tables or gene lists. All are...
Abstract The wide applications of liquid chromatography - mass spectrometry (LC-MS) in untargeted metabolomics demand an easy-to-use, comprehensive computational workflow to support efficient and reproducible data analysis. However, current tools were primarily developed perform specific tasks LC-MS based Here we introduce MetaboAnalystR 4.0 as a streamlined pipeline covering raw spectra processing, compound identification, statistical analysis, functional interpretation. key features...
Abstract An important provision of the Minamata Convention on Mercury is to monitor and evaluate effectiveness adopted measures its implementation. Here, we describe for first time currently available biotic mercury (Hg) data a global scale improve understanding efforts reduce impact Hg pollution people environment. Data from peer-reviewed literature were compiled in Global Biotic Synthesis (GBMS) database (>550,000 points). These provide foundation establishing biomonitoring framework...
Polar bears (Ursus maritimus) are exposed to high concentrations of mercury because they apex predators in the Arctic ecosystem. Although is a potent neurotoxic heavy metal, it not known whether current exposures neurotoxicological concern polar bears. We tested hypotheses that accumulate levels their brains exceed estimated lowest observable adverse effect level (20 microg/g dry wt) for mammalian wildlife and such associated with subtle neurological damage, as determined by measuring...
Threshold concentrations associated with adverse effects of dietary exposure to methylmercury (MeHg) were derived from published results laboratory studies on a variety fish species. Adverse related mortality uncommon, whereas growth occurred only at MeHg exceeding 2.5 µg g(-1) wet weight. behavior had wide range effective concentrations, but generally above 0.5 In contrast, reproduction and other subclinical endpoints that much lower (<0.2 wt). Field lack information exposure, yet available...
In this paper we describe a novel approach that may shed light on the genomic DNA methylation of organisms with non-resolved genomes. The LUminometric Methylation Assay (LUMA) is permissive for studies any genome as it relies use methyl-sensitive and -insensitive restriction enzymes followed by polymerase extension via Pyrosequencing technology. Here, LUMA was used to characterize in lower brain stem region from 47 polar bears subsistence hunted central East Greenland between 1999 2001....
We performed two controlled experiments to determine the amount of mass-dependent and mass-independent fractionation (MDF MIF) methylmercury (MeHg) during trophic transfer into fish. In experiment 1, juvenile yellow perch (Perca flavescens) were raised in captivity on commercial food pellets then their diet was either maintained unamended (0.1 μg/g MeHg) or switched with 1.0 4.0 added MeHg, for a period 2 months. The difference δ(202)Hg (MDF) Δ(199)Hg (MIF) between fish tissues MeHg within...