A5078987114- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Heavy metals in environment
- Mercury impact and mitigation studies
- Air Quality and Health Impacts
- Fluoride Effects and Removal
- Health, Environment, Cognitive Aging
- Climate Change and Health Impacts
- Noise Effects and Management
- Child Nutrition and Water Access
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Bone health and osteoporosis research
- Nutritional Studies and Diet
- Environmental Justice and Health Disparities
- Iron Metabolism and Disorders
- Dental Health and Care Utilization
- Radioactivity and Radon Measurements
- Vaccine Coverage and Hesitancy
- Epigenetics and DNA Methylation
- Arsenic contamination and mitigation
- Health disparities and outcomes
- Pesticide Exposure and Toxicity
- Pregnancy and preeclampsia studies
- Carcinogens and Genotoxicity Assessment
University of Southern California
2013-2025
Keck Hospital of USC
2024
University of Michigan
2012-2024
Shaanxi Normal University
2024
University of Maryland, Baltimore
2024
Hainan Medical University
2024
University of Macau
2020-2023
Second Affiliated Hospital of Zhejiang University
2023
University of Washington
2018-2022
University of Toronto
1994-2022
Fish and other seafood may contain organic mercury but also beneficial nutrients such as n-3 polyunsaturated fatty acids. We endeavored to study whether maternal fish consumption during pregnancy harms or benefits fetal brain development. examined associations of intake hair at delivery with infant cognition among 135 mother–infant pairs in Project Viva, a prospective U.S. child cohort study. assessed by the percent novelty preference on visual recognition memory (VRM) testing 6 months age....
The balance of contaminant risk and nutritional benefit from maternal prenatal fish consumption for child cognitive development is not known. Using data a prospective cohort study 341 mother-child pairs in Massachusetts enrolled 1999–2002, the authors studied associations second-trimester intake erythrocyte mercury levels with children's scores on Peabody Picture Vocabulary Test (PPVT) Wide Range Assessment Visual Motor Abilities (WRAVMA) at age 3 years. Mean total was 1.5 (standard...
We previously demonstrated that exposure to polyvinyl chloride plastic medical devices containing di(2-ethylhexyl) phthalate (DEHP) was associated with higher urinary concentrations of several DEHP metabolites in 54 premature infants two neonatal intensive care units than the general population. For 42 these infants, we evaluated phenols, including bisphenol A (BPA), association use same devices.
BackgroundThe impact of prenatal lead exposure on neurodevelopment remains unclear in terms consistency, the trimester greatest vulnerability, and best method for estimating fetal exposure.ObjectiveWe studied exposure's using repeated measures dose as reflected by maternal whole blood plasma levels.MethodsWe measured during each 146 pregnant women Mexico City. We then umbilical cord at delivery and, when offspring were 12 24 months age, administered Bayley Scales Infant Development. used...
Fetal lead exposure is associated with adverse pregnancy outcomes and developmental cognitive deficits; however, the mechanism(s) by which lead-induced toxicity occurs remains unknown. Epigenetic fetal programming via DNA methylation may provide a pathway environmental can influence disease susceptibility.This study was designed to determine whether prenatal alterations in genomic of leukocyte levels from umbilical cord samples.We measured methylation, as assessed Alu LINE-1 (long...
Recent evidence suggests that low-level environmental exposure to manganese adversely affects child growth and neurodevelopment. Previous studies have addressed the effects of prenatal exposure, but little is known about developmental early postnatal exposure.
Evidence supports a role for epigenetic mechanisms in the pathogenesis of late-onset Alzheimer's disease (LOAD), but little has been done on genome-wide scale to identify potential sites involved disease. This study investigates human postmortem
Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures exposure, addressed impact prenatal exposures or involved more than 100 participants.Our aim was estimate association exposure with offspring neurocognitive development.We studied participants from Early Life Exposures in Mexico Environmental Toxicants (ELEMENT) project. An ion-selective electrode technique used measure archived urine samples...
<h3>Objective.</h3> —To test the hypothesis that long-term lead accumulation, as reflected by levels of in bone (as opposed to blood, which reflects recent exposure), is associated with an increased odds developing hypertension. <h3>Design.</h3> —Case-control study participants Veterans Administration (now Department Affairs) Normative Aging Study, a 30-year longitudinal men. <h3>Participants.</h3> —Of 1171 active subjects who were seen between August 1991 and December 1994, 590 (50%)...
Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in medical products made with polyvinyl chloride (PVC) plastic and may be toxic to humans. DEHP lipophilic binds noncovalently PVC, allowing it leach from these products. Medical devices containing are extensively neonatal intensive care units (NICUs). Among neonates NICUs, we studied exposure DEHP-containing relation urinary levels of mono(2-ethylhexyl) (MEHP), metabolite DEHP.We cross-sectional design for this study.We 54 admitted...
OBJECTIVE. Increasing evidence suggests that 10 μg/dL, the current Centers for Disease Control and Prevention screening guideline children's blood lead level, should not be interpreted as a level at which adverse effects do occur. Using data from prospective study conducted in Mexico City, Mexico, we evaluated dose-effect relationship between levels neurodevelopment 12 24 months of age. METHODS. The population consisted 294 children whose both age were &lt;10 μg/dL; measured by graphite...
Rates of preterm birth have been rising over the past several decades. Factors contributing to this trend remain largely unclear, and exposure environmental contaminants may play a role.We investigated relationship between phthalate birth.Within large Mexican cohort study, we compared third-trimester urinary metabolite concentrations in 30 women who delivered (< 37 weeks gestation) with those controls (> or = gestation).Concentrations most metabolites were similar reported among U.S....
Objectives. Birth weight predicts infant survival, growth, and development. Previous research suggests that low levels of fetal lead exposure, as estimated by umbilical cord blood-lead at birth, may have an adverse effect on birth weight. This report examines the relationship in blood maternal bone to Methods. Umbilical venous samples anthropometric sociodemographic data were obtained delivery 1-month postpartum. Blood-lead analyzed atomic absorption spectrophotometry. Maternal tibia patella...
DNA methylation is an epigenetic mark that regulates gene expression. Changes in within white blood cells may result from cumulative exposure to environmental metals such as lead. Bone lead, a marker of exposure, therefore better predict than does lead.In this study we compared associations between lead biomarkers and methylation.We measured global participants the Normative Aging Study (all men) who had archived samples. We patella tibia levels by K-X-Ray fluorescence atomic absorption...
Most toxicologic studies focus on a single agent, although this does not reflect real-world scenarios in which humans are exposed to multiple chemicals.We prospectively studied manganese-lead interactions early childhood examine whether coexposure is associated with neurodevelopmental deficiencies that more severe than expected based effects of exposure each metal alone.Four hundred fifty-five children were enrolled at birth an longitudinal cohort study Mexico City, provided blood samples,...