A5066530115- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Bacterial Genetics and Biotechnology
- Antibiotic Resistance in Bacteria
- Biochemical and Structural Characterization
- Immune Response and Inflammation
- Bacteriophages and microbial interactions
- Lipid Membrane Structure and Behavior
- RNA and protein synthesis mechanisms
- Chemical Synthesis and Analysis
- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- vaccines and immunoinformatics approaches
- Pediatric health and respiratory diseases
- Protein Hydrolysis and Bioactive Peptides
- Antibiotics Pharmacokinetics and Efficacy
- Invertebrate Immune Response Mechanisms
- Immunotherapy and Immune Responses
- Antimicrobial agents and applications
- Cystic Fibrosis Research Advances
- Oral microbiology and periodontitis research
- Bioinformatics and Genomic Networks
- Probiotics and Fermented Foods
- Antimicrobial Resistance in Staphylococcus
- Polydiacetylene-based materials and applications
University of British Columbia
2016-2025
Nepean Hospital
2022
The University of Sydney
2022
Canadian Institutes of Health Research
2022
BC Innovation Council
2022
NanoMedicines Innovation Network
2022
Vancouver Biotech (Canada)
2015-2021
Wellcome Sanger Institute
2013-2020
Institute of Infection and Immunity
2004-2019
Silesian University of Technology
2012-2019
The growing application of gene expression profiling demands powerful yet user-friendly bioinformatics tools to support systems-level data understanding. NetworkAnalyst was first released in 2014 address the key need for interpreting within context protein-protein interaction (PPI) networks. It soon updated meta-analysis with improved workflow and performance. Over years, has been continuously based on community feedback technology progresses. Users can now perform 17 different species. In...
InnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes. In this article, we provide details recent updates improvements the database. now contains >196 000 human, mouse bovine experimentally validated molecular interactions 3000 pathway annotations relevance all cellular systems (i.e. not just immune relevant interactions). addition, team has,...
Antimicrobial cationic peptides are prevalent throughout nature as part of the intrinsic defenses most organisms, and have been proposed a blueprint for design novel antimicrobial agents. They known to interact with membranes, it has frequently that this represents their antibacterial target. To see if was general mechanism action, we studied interaction, model membranes cytoplasmic membrane Escherichia coli, 12 representing all 4 structural classes peptides. Planar lipid bilayer studies...
Abstract The role of LL-37, a human cationic antimicrobial peptide, in the immune system is not yet clearly understood. It widely expressed peptide that can be up-regulated during an response. In this report, we demonstrate LL-37 potent antisepsis agent with ability to inhibit macrophage stimulation by bacterial components such as LPS, lipoteichoic acid, and noncapped lipoarabinomannan. We also protects mice against lethal endotoxemia. addition preventing activation components, hypothesized...