A5017600873- Gut microbiota and health
- Neonatal Respiratory Health Research
- Bioinformatics and Genomic Networks
- Diabetes and associated disorders
- RNA and protein synthesis mechanisms
- Cancer, Stress, Anesthesia, and Immune Response
- vaccines and immunoinformatics approaches
- Tryptophan and brain disorders
- interferon and immune responses
- Clostridium difficile and Clostridium perfringens research
- Cancer Immunotherapy and Biomarkers
- Infant Nutrition and Health
- Single-cell and spatial transcriptomics
- Congenital Diaphragmatic Hernia Studies
- Dietary Effects on Health
- PARP inhibition in cancer therapy
- Immune responses and vaccinations
South Australian Health and Medical Research Institute
2018-2021
University of British Columbia
2010-2012
InnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes. In this article, we provide details recent updates improvements the database. now contains >196 000 human, mouse bovine experimentally validated molecular interactions 3000 pathway annotations relevance all cellular systems (i.e. not just immune relevant interactions). addition, team has,...
Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or mice with reduced because of genetic deficiency. We investigate effect early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these for more than 700 days in comparison untreated control mice. demonstrate emergence two different low-diversity community types, post-antibiotic (PAM) I PAM II, following...
The innate immune response is the first line of defence against invading pathogens and regulated by complex signalling transcriptional networks. Systems biology approaches promise to shed new light on regulation immunity through analysis modelling these A key initial step in this process contextual cataloguing components system molecular interactions that comprise InnateDB ( http://www.innatedb.com ) a interaction pathway database developed facilitate systems-level analyses immunity. Here,...
Bronchopulmonary dysplasia (BPD) is a common chronic lung condition in preterm infants that results abnormal development and leads to considerable morbidity mortality, making BPD one of the most complications birth. We employed RNA sequencing 16S rRNA gene profile expression blood composition fecal microbiota born at <29 weeks gestational age diagnosed with comparison those were not BPD. sequencing, performed longitudinally on 255 samples collected from 50 first months life, identified...
Immune agonist antibodies (IAAs) are promising immunotherapies that target co-stimulatory receptors to induce potent anti-tumor immune responses, particularly when combined with checkpoint inhibitors. Unfortunately, their clinical translation is hampered by serious dose-limiting, immune-mediated toxicities, including high-grade and sometimes fatal liver damage, cytokine release syndrome (CRS), colitis. We show the immunotoxicity, induced IAAs anti-CD40 anti-CD137, dependent on gut...