A5088416416- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Endometrial and Cervical Cancer Treatments
- RNA Interference and Gene Delivery
- Viral-associated cancers and disorders
- Cannabis and Cannabinoid Research
- Eating Disorders and Behaviors
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Preterm Birth and Chorioamnionitis
- Bioinformatics and Genomic Networks
- Neonatal Respiratory Health Research
- Immune responses and vaccinations
- Diet, Metabolism, and Disease
- Respiratory viral infections research
- Neurotransmitter Receptor Influence on Behavior
- Dietary Effects on Health
- Vaccine Coverage and Hesitancy
- vaccines and immunoinformatics approaches
- Respiratory and Cough-Related Research
University of Pennsylvania
2023
University of Cincinnati Medical Center
2017-2021
Cincinnati Children's Hospital Medical Center
2017-2021
University of Cincinnati
2017-2021
California Pacific Medical Center
2005-2020
Sutter Health
2020
National Cancer Institute
2015
National Institutes of Health
2012
National Institute of Allergy and Infectious Diseases
2012
University of British Columbia
2008-2010
Article2 September 2008Open Access InnateDB: facilitating systems-level analyses of the mammalian innate immune response David J Lynn Corresponding Author Department Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada Centre for Microbial Diseases Immunity Research, University Vancouver, Search more papers by this author Geoffrey L Winsor Calvin Chan Nicolas Richard Matthew R Laird Aaron Barsky Computer Science, Jennifer Gardy Fiona M Roche Timothy...
Abstract White adipose tissue inflammation, in part via myeloid cell contribution, is central to obesity pathogenesis. Mechanisms regulating adipocyte inflammatory potential and consequent impact of such inflammation disease pathogenesis remain poorly defined. We show that activation the type I interferon (IFN)/IFNα receptor (IFNAR) axis amplifies vigor uncovers dormant gene expression patterns resembling cells. IFNβ-sensing promotes glycolysis, while glycolysis inhibition impeded...
The innate immune response is the first line of defence against invading pathogens and regulated by complex signalling transcriptional networks. Systems biology approaches promise to shed new light on regulation immunity through analysis modelling these A key initial step in this process contextual cataloguing components system molecular interactions that comprise InnateDB ( http://www.innatedb.com ) a interaction pathway database developed facilitate systems-level analyses immunity. Here,...
RNA silencing inhibits mRNA translation. While translation accounts for the majority of cellular energy expenditure, it is unclear if regulates homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated both intrinsic production and consumption disturbs metabolism in pathogenesis obesity. Ago2 expression specific miRNAs including miR-802, miR-103/107, miR-148a/152, causing metabolic disruption, while simultaneously suppressing genes regulating glucose lipid metabolism, Hnf1β,...
Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 plays an essential role in KSHV lytic infection by promoting viral gene expression at the posttranscriptional level. Using bioinformatic and biochemical approaches, we determined that contains two structurally functionally distinct domains: a disordered nonstructural N-terminal domain (amino acids [aa] 1 to 152) structured α-helix-rich C-terminal (aa 153 455). The mediates interaction with several RNA-protein complexes for function....
Abstract The impact of immune mediators on weight homeostasis remains underdefined. Interrogation resistance to diet-induced obesity in mice lacking a negative regulator Toll-like receptor signaling serendipitously uncovered role for B cell activating factor (BAFF). Here we show that overexpression BAFF multiple mouse models associates with protection from gain, approximating log-linear dose response relation concentrations. Gene expression analysis BAFF-stimulated subcutaneous white...
Nonalcoholic fatty liver disease (NAFLD) represents a spectrum ranging from benign steatosis to life‐threatening cirrhosis and hepatocellular carcinoma. Elevated levels of reactive oxygen species (ROS) exacerbated inflammatory responses have been implicated in NAFLD progression. Nicotinamide adenine dinucleotide phosphate (reduced) oxidase 2 (NOX2; also known as gp91 Phox ), the main catalytic subunit nicotinamide complex, modulates ROS production, immune responsiveness, pathogenesis...
Abstract Preterm birth (PTB) is the leading cause of neonatal mortality worldwide. Infection and inflammation are considered main causes PTB. Among multiple pathogens, Gram-positive bacteria commonly linked with induction Although activation innate immune responses, via TLR2 engagement, by a likely cause, whether PTB depends on potency specific microbial components to induce Toll-like receptor (TLR)2-driven has not been elucidated. Here, we show that synthetic lipopeptides, Pam2Cys, Pam3Cys...
Abstract Background Ribonuclease 8 is a member of the RNase A family secretory ribonucleases; orthologs this gene have been found only in primate genomes. divergent paralog 7, which lysine-enriched, highly conserved, has prominent antimicrobial activity, and expressed both normal diseased skin; contrast, physiologic function remains uncertain. Here, we examine genetic diversity human 8, subject significant interest given existence functional pseudogenes (coding sequences that are otherwise...
Abstract Objective The risks of excess sugar intake in addition to high-fat diet consumption on immunopathogenesis obesity-associated metabolic diseases are poorly defined. Interleukin-4 (IL-4) and IL-13 signaling via IL-4Rα regulates adipose tissue lipolysis, insulin sensitivity, liver fibrosis obesity. However, the contribution rich diet-driven obesity sequelae remains unknown. Methods WT, IL-4Rα-deficient (IL-4Rα −/− ) STAT6-deficient mice (STAT6 male were fed low-fat chow, high fat (HF)...
The dorsal vagal complex (DVC) of the hindbrain is a major point integration for central and peripheral signals that regulate wide variety metabolic functions to maintain energy balance. REV-ERB nuclear receptors are important modulators molecular metabolism, but their role in DVC has yet be established. Male REV-ERBα/β floxed mice received stereotaxic injections Cre expressing virus create double knockout (DVC RDKO). Control littermates green fluorescent protein virus. Animals were...
<h3>Objective</h3> To evaluate the relationship between obesity and incidence of type I endometrial cancer in two large population cohorts. <h3>Methods</h3> From 2001 to 2016, rates were estimated from United States Cancer Statistics data. Hysterectomy, pregnancy, derived Behavioral Risk Factor Surveillance System (BRFSS). SEER*Stat Joinpoint regression used calculate rate (per 100,000). <h3>Results</h3> A total 531,481 patients diagnosed with cancer, 385,821 grade 1 or 2 endometrioid...