A5038241870- Ovarian cancer diagnosis and treatment
- vaccines and immunoinformatics approaches
- Prostate Cancer Diagnosis and Treatment
- Antimicrobial Peptides and Activities
- Radiopharmaceutical Chemistry and Applications
- Immune Response and Inflammation
- Prostate Cancer Treatment and Research
- Lymphoma Diagnosis and Treatment
- Streptococcal Infections and Treatments
- Oral microbiology and periodontitis research
- Cancer, Lipids, and Metabolism
- Immune responses and vaccinations
- Antibiotics Pharmacokinetics and Efficacy
- Central Venous Catheters and Hemodialysis
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Protein Hydrolysis and Bioactive Peptides
- Neuroendocrine Tumor Research Advances
- interferon and immune responses
- Invertebrate Immune Response Mechanisms
- Pancreatic and Hepatic Oncology Research
- Clinical Laboratory Practices and Quality Control
- Pancreatitis Pathology and Treatment
- Chronic Lymphocytic Leukemia Research
The University of Queensland
2021-2023
Royal Brisbane and Women's Hospital
2021-2023
QIMR Berghofer Medical Research Institute
2021
Woman's Hospital
2021
University of British Columbia
2008-2009
Okanagan University College
2008
Article2 September 2008Open Access InnateDB: facilitating systems-level analyses of the mammalian innate immune response David J Lynn Corresponding Author Department Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada Centre for Microbial Diseases Immunity Research, University Vancouver, Search more papers by this author Geoffrey L Winsor Calvin Chan Nicolas Richard Matthew R Laird Aaron Barsky Computer Science, Jennifer Gardy Fiona M Roche Timothy...
ABSTRACT Streptococcus salivarius is an early colonizer of human oral and nasopharyngeal epithelia, strain K12 has reported probiotic effects. An emerging paradigm indicates that commensal bacteria downregulate immune responses through the action on NF-κB signaling pathways, but additional mechanisms underlying actions are not well understood. Our objective here was to identify host genes specifically targeted by comparing their with elicited pathogens determine if S. modulates epithelial...
The immune system is very complex, it involves the integrated regulation and expression of hundreds proteins. To understand in greater detail how human host defence immunomodulatory peptide LL-37 interacts with innate immunity, a systems approach was pursued. Polychromatic flow cytometry employed to demonstrate that within peripheral blood mononuclear cells, CD14+ monocytes, myeloid plasmocytoid dendritic cells T- B-lymphocytes, all responded LL-37, differential production...
Abstract Background Accurate prostate cancer imaging is critical for patient management. Multiple studies have demonstrated superior diagnostic accuracy of [ 68 Ga]-PSMA-11 PET/CT over conventional disease detection, with validated clinical and biochemical predictors detection. More recently 18 F]PSMA-1007 offers theoretical advantages, but there limited evidence scan findings in the staging population. This study investigates association variables characteristics among patients who...
Cardiac metastases from neuroendocrine neoplasms (NENs) are being detected with increasing frequency, although the optimal imaging strategy remains unclear. We performed a single-center retrospective study to explore role of somatostatin receptor positron emission tomography/computed tomography (SSTR PET/CT) and cardiac magnetic resonance (CMR) in NEN metastases, determine degree concordance between findings these modalities, examine advantages disadvantages each technique. A secondary aim...
Abstract Cationic host defence (antimicrobial) peptides, e.g. cathelicidin LL-37, have a variety of immunomodulatory activities that favour the safe resolution infections. We studied novel synthetic cationic innate regulator peptides are not directly antimicrobial but anti-infective in vivo, due to modulation immunity. A range derived from small bovine peptide bactenecin were screened for vitro; promotion chemokine production and suppression pro-inflammatory cytokines. Since immunity is...
Abstract Purpose : Accurate prostate cancer imaging is critical for patient management. Multiple studies have demonstrated superior diagnostic accuracy of [ 68 Ga]-PSMA-11 PET/CT over conventional disease detection, with validated clinical and biochemical predictors detection. More recently 18 F]PSMA-1007 offers theoretical advantages, but there limited evidence scan findings in the staging population. This study investigates correlation variables characteristics among patients who underwent...