A5025401318- Immune responses and vaccinations
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Vaccine Coverage and Hesitancy
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- COVID-19 Impact on Reproduction
- HIV Research and Treatment
- Infant Nutrition and Health
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Gut microbiota and health
- Neonatal and Maternal Infections
- Hepatitis B Virus Studies
- Diabetes and associated disorders
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Child Nutrition and Water Access
- Streptococcal Infections and Treatments
- Single-cell and spatial transcriptomics
Dalhousie University
2014-2025
University of British Columbia
2016-2025
British Columbia Children's Hospital
2013-2025
The Kids Research Institute Australia
2019-2024
Princess Margaret Hospital for Children
2020-2024
Perth Children's Hospital
2021-2024
The University of Western Australia
2019-2023
Royal Children's Hospital
2023
Boston Children's Hospital
2018
Child and Family Research Institute
2008-2017
Asthma is the most prevalent pediatric chronic disease and affects more than 300 million people worldwide. Recent evidence in mice has identified a "critical window" early life where gut microbial changes (dysbiosis) are influential experimental asthma. However, current research yet to establish whether these precede or involved human We compared microbiota of 319 subjects enrolled Canadian Healthy Infant Longitudinal Development (CHILD) Study, show that infants at risk asthma exhibited...
Abstract A fundamental tenet of scientific research is that published results are open to independent validation and refutation. Minimum data standards aid providers, users, publishers by providing a specification what required unambiguously interpret experimental findings. Here, we present the Information about Flow Cytometry Experiment (MIFlowCyt) standard, stating minimum information report flow cytometry (FCM) experiments. We brought together cross‐disciplinary international...
Abstract The human neonate and infant are unduly susceptible to infection with a wide variety of microbes. This susceptibility is thought reflect differences from adults in innate adaptive immunity, but the nature these incompletely characterized. immune response directs subsequent after integrating information TLRs other environmental sensors. We set out provide comprehensive analysis defining TLR ligation between neonates adults. In most ligands, neonatal cells, including monocytes...
CANCER ISthe second most common cause of cancer morbidity and mortality in women. 1 Human papillomavirus (HPV) infection has been identified as a necessary for the development cervical cancer, with HPV genotypes 16 18 accounting approximately 70% cases.Prevention using either bivalent (HPV-16 HPV-18) or quadrivalent (HPV-6, HPV-11, HPV-16, vaccine is goal immu-
The global pandemic of COVID-19 cases caused by infection with SARS-CoV-2 is ongoing, no approved antiviral intervention. We describe here the effects treatment interferon-α2b in a cohort confirmed Wuhan, China. In this uncontrolled, exploratory study, 77 adults hospitalized were treated either nebulized IFN-α2b (5mU b.i.d.), arbidol (200mg t.i.d.) or combination plus arbidol. Serial testing along hematological measurements, including cell counts, blood biochemistry and serum cytokine...
The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical psychosocial environments, immunological, physiological, nutritional, hormonal metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental biological sampling, innate adaptive immune responses, gene expression, DNA methylation, gut microbiome nutrition...
Systems biology can unravel complex but has not been extensively applied to human newborns, a group highly vulnerable wide range of diseases. We optimized methods extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml blood, volume readily obtained newborns. Indexing baseline applying innovative integrative computational reveals dramatic changes along remarkably stable developmental trajectory over the first week life. This is...
The bacille Calmette-Guérin (BCG) vaccine has immunomodulatory "off-target" effects that have been hypothesized to protect against coronavirus disease 2019 (Covid-19).
Newborns and young infants suffer increased infectious morbidity mortality as compared to older children adults. Morbidity due infection are highest during the first weeks of life, decreasing over several years. Furthermore, most vaccines not administered around birth, but few years life. A more complete understanding ontogeny immune system life is thus urgently needed. Here, we applied comprehensive analysis focused on innate response following TLR stimulation 2 in largest such longitudinal...
HIV-exposed uninfected (HEU) infants have higher infectious morbidity than HIV-unexposed (HUU) infants. We present the clinical outcomes from a pilot cohort study of 27 HEU and 28 HUU In absence infant malnutrition or advanced maternal HIV, experienced 2.74 (0.85–8.78) times greater risk hospitalization in first year.
Background. The decline in influenza vaccine efficacy older adults is associated with a limited ability of current split-virus vaccines (SVVs) to stimulate cytotoxic T lymphocyte (CTL) responses required for clinical protection against influenza.