A5010815891- HIV/AIDS Research and Interventions
- Cervical Cancer and HPV Research
- HIV, Drug Use, Sexual Risk
- Reproductive tract infections research
- Hepatitis B Virus Studies
- HIV-related health complications and treatments
- Adolescent Sexual and Reproductive Health
- Genital Health and Disease
- Cytomegalovirus and herpesvirus research
- COVID-19 Impact on Reproduction
- Herpesvirus Infections and Treatments
- Urinary Tract Infections Management
- Pregnancy and Medication Impact
- Vaccine Coverage and Hesitancy
- Preterm Birth and Chorioamnionitis
- HIV Research and Treatment
- Reproductive Health and Contraception
- Sex work and related issues
- Parvovirus B19 Infection Studies
- Pelvic floor disorders treatments
- Syphilis Diagnosis and Treatment
- Neonatal and Maternal Infections
- Streptococcal Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
University of British Columbia
2016-2025
B.C. Women's Hospital & Health Centre
2015-2025
Women's Health Research Institute
2016-2025
University of British Columbia Hospital
2005-2024
Children's & Women's Health Centre of British Columbia
2003-2023
University of Manitoba
1997-2023
Public Health Ontario
2023
Toronto Public Health
2023
University of Toronto
2018-2023
Memorial University of Newfoundland
2023
CANCER ISthe second most common cause of cancer morbidity and mortality in women. 1 Human papillomavirus (HPV) infection has been identified as a necessary for the development cervical cancer, with HPV genotypes 16 18 accounting approximately 70% cases.Prevention using either bivalent (HPV-16 HPV-18) or quadrivalent (HPV-6, HPV-11, HPV-16, vaccine is goal immu-
The vaginal microbial community plays a vital role in maintaining women's health. Understanding the precise bacterial composition is challenging because of diverse and difficult-to-culture nature many constituents, necessitating culture-independent methodology. During natural menstrual cycle, physiological changes could have an impact on growth, colonization, structure. objective this study was to assess stability microbiome healthy Canadian women throughout cycle by using cpn 60-based...
The vaginal microbiome plays an important role in maternal and neonatal health. Imbalances this microbiota (dysbiosis) during pregnancy are associated with negative reproductive outcomes, such as loss preterm birth, but the underlying mechanisms remain poorly understood. Consequently a comprehensive understanding of baseline healthy is needed. We characterized microbiomes pregnant women at 11-16 weeks gestational age (n = 182) compared them to those non-pregnant 310). Profiles were created...
The bacterial community present in the female lower genital tract plays an important role maternal and neonatal health. Imbalances this microbiota have been associated with negative reproductive outcomes, such as spontaneous preterm birth (sPTB), but mechanisms underlying association between a disturbed sPTB remain poorly understood. An intrauterine infection ascending from vagina is thought to be contributor onset of labour. Our objective was characterize vaginal pregnant women who had (n =...
There are limited high-quality, population-level data about the effect of SARS-CoV-2 infection on pregnancy using contemporaneous comparator cohorts.To describe maternal and perinatal outcomes associated with in to assess variables severe disease pregnant population.CANCOVID-Preg is an observational surveillance program for SARS-CoV-2-affected pregnancies Canada. This analysis presents exploratory, from 6 Canadian provinces period March 1, 2020, October 31, 2021. A total 6012 persons a...
Information on factors that influence parental decisions for actual human papillomavirus (HPV) vaccine receipt in publicly funded, school-based HPV programs girls is limited. We report the level of uptake first dose vaccine, and determine associated with a funded program British Columbia, Canada.All parents enrolled grade 6 during academic year September 2008-June 2009 province Columbia were eligible to participate. Eligible households identified through provincial public health information...
<b>Background:</b> Concerns have been raised that parents may be reluctant to their daughters receive the human papillomavirus (HPV) vaccine, because of a belief doing so might interpreted as condoning earlier and more frequent sexual activity. We determined intentions regarding vaccination among Canadian factors predicted parental intention vaccinated against HPV. <b>Methods:</b> Parents children 8–18 years age, recruited from across Canada, were asked respond questions in context grade 6,...
The Canadian Women's HIV Study (CWHS) enrolled human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women in a longitudinal cohort. This analysis considered the effects of highly active antiretroviral therapy (HAART) on HPV persistence cervical squamous intraepithelial lesions (SILs).Longitudinal cytopathologic DNA results were analyzed using multistate models. States SIL defined as absent, present, treatment; states negative or positive. Demographic variables markers...
The vaginal microbiota is important in women's reproductive and overall health. However, the relationships between structure, function dynamics of this complex microbial community health outcomes remain elusive. objective study was to determine phylogenetic range abundance prokaryotes healthy, non-pregnant, ethnically diverse, reproductive-aged Canadian women. Socio-demographic, behavioural clinical data were collected swabs analyzed from 310 Detailed profiles their microbiomes generated by...
The control arm of the phase III VIVIANE (Human PapillomaVIrus: Vaccine Immunogenicity ANd Efficacy; NCT00294047) study in women >25 years was studied to assess risk progression from cervical HPV infection detectable intraepithelial neoplasia (CIN). detecting CIN associated with same type as reference analysed using Kaplan–Meier and multivariable Cox models. Infections were categorised depending upon persistence 6‐month persistent (6MPI) or any duration. 4‐year interim analysis included...
Immunization of pregnant women with tetanus-diphtheria-acellular pertussis vaccine (Tdap) provides protection against to the newborn infant.In a randomized, controlled, observer-blind, multicenter clinical trial, we measured safety and immunogenicity Tdap during pregnancy effect on infant's immune response primary vaccination at 2, 4, 6 months booster 12 age. A total 273 received either or tetanus-diphtheria (Td) in third trimester provided information for analysis samples analyses; 261...
To characterize the vaginal microbiota of women following preterm premature rupture membranes (PPROM), and determine if microbiome composition predicts latency duration perinatal outcomes.A prospective cohort study.Canada.Women with PPROM between 24+0 33+6 weeks gestational age (GA).Microbiome profiles, based on pyrosequencing cpn60 universal target, were generated from samples at time presentation PPROM, weekly thereafter, delivery.Vaginal composition, duration, delivery,...
The COVID-19 pandemic posed a unique set of risks to pregnant women and people. SARS-CoV-2 infection in pregnancy is associated with increased risk severe illness adverse perinatal outcomes. However, evidence regarding the use vaccines shows safety efficacy. Despite eligibility recommendations for vaccination among people Canada, uptake remains lower compared general population, warranting exploration influencing factors. COVERED study, national prospective cohort, utilized web-based surveys...
We investigated whether the intention to have children varied according HIV status and use of highly active antiretroviral therapy (HAART) among women in Soweto, South Africa.We used survey data from 674 aged 18 44 years recruited Perinatal Research Unit Soweto (May through December 2007); 217 were HIV-positive HAART users (median duration = 31 months; interquartile range 28, 33), 215 HAART-naive, 242 negative. Logistic regression models examined associations between status, use,...