A5082822397- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Pancreatic function and diabetes
- Antioxidant Activity and Oxidative Stress
- Diabetes Treatment and Management
- Circular RNAs in diseases
- Retinoids in leukemia and cellular processes
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Dietary Effects on Health
- Bariatric Surgery and Outcomes
- Eating Disorders and Behaviors
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Sirtuins and Resveratrol in Medicine
- Natural Compounds in Disease Treatment
- Gut microbiota and health
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Mitochondrial Function and Pathology
- Olfactory and Sensory Function Studies
- Receptor Mechanisms and Signaling
German Center for Diabetes Research
2016-2025
Deutsches Diabetes-Zentrum e.V.
2016-2025
Helmholtz Zentrum München
2016-2025
Technical University of Munich
2013-2025
Heinrich Heine University Düsseldorf
2016-2025
Center for Environmental Health
2012-2024
Diabetes Australia
2012-2024
Helmholtz Centre for Environmental Research
2024
Yale University
2012-2023
Universität Hamburg
2023
The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is crucial importance. Excessive exposure dietary lipids causes inflammatory responses, deranges homeostasis cellular metabolism, believed constitute a key initiator syndrome. Mammalian Sirt1 protein deacetylase that has been involved in resveratrol-mediated protection from high-fat diet-induced damage, but direct proof for implication remained elusive. Here, we report mice...
Compared to best-in-class GLP-1 mono-agonists, unimolecular co-agonists of and GIP with optimized pharmacokinetics enhance glycemic metabolic benefits in mammals.
The neuronal circuits involved in the regulation of feeding behavior and energy expenditure are soft-wired, reflecting relative activity postsynaptic system, including anorexigenic proopiomelanocortin (POMC)-expressing cells arcuate nucleus. We analyzed synaptic input organization melanocortin system lean rats that were vulnerable (DIO) or resistant (DR) to diet-induced obesity. found a distinct difference quantitative qualitative synaptology POMC between DIO DR animals, with significantly...
Disruptions of the melanocortin signaling system have been linked to obesity. We investigated a possible role central nervous (CNS-Mcr) in control adiposity through effects on nutrient partitioning and cellular lipid metabolism independent intake. report that pharmacological inhibition receptors (Mcr) rats genetic disruption Mc4r mice directly potently promoted uptake, triglyceride synthesis, fat accumulation white adipose tissue (WAT), while increased CNS-Mcr triggered mobilization. These...
Metabolism Without Modification Obesity-associated metabolic disease has rapidly become a public health priority in the developed world and is being addressed through prevention strategies aimed at lifestyle changes pharmacological approaches. Barnett et al. (p. 1689 , published online 18 November) designed drug that inhibits action of ghrelin, circulating peptide hormone increases fat mass food intake. The drug, bisubstrate analog called GO-CoA-Tat, selective antagonist ghrelin...
Glucagon, an essential regulator of glucose homeostasis, also modulates lipid metabolism and promotes weight loss, as reflected by the wasting observed in glucagonoma patients. Recently, coagonist peptides that include glucagon agonism have emerged promising therapeutic candidates for treatment obesity diabetes. We developed a novel stable soluble receptor (GcgR) agonist, which allowed vivo dissection action. As expected, chronic GcgR mice resulted hyperglycemia lower body fat plasma...
Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and SILAC-labeling (phospho)proteomics, revealed AdEVs transfer functional insulinotropic protein cargo into pancreatic β-cells. Upon transfer, AdEV proteins were subjects for phosphorylation, augmented GPCR/cAMP/PKA signaling by increasing total...
Ghrelin stimulates food intake and adiposity thereby increases body weight (BW) in rodents after central as well peripheral administration. Recently, it was discovered that the gene precursor of ghrelin encoded another secreted bioactive peptide named obestatin. First reports appeared to demonstrate this requires an amidation for its biological activity acts through orphan receptor, GPR-39. Obestatin shown have actions opposite on intake, BW, gastric emptying. In present study, we failed...
Recent findings suggest that low plasma peptide YY (PYY) levels may contribute to diet-induced human obesity and justify PYY replacement therapy. Although the pharmacological value of is controversial, further study secretion precursor PYY(1-36) pharmacologically active PYY(3-36) indicated determine potential role in energy balance regulation.Our objective was effects acute chronic changes body weight on circulating putative satiety hormone YY.Total (PYY(1-36) + PYY(3-36)) were measured 66...
Administration of chemically synthesized ghrelin (Ghr) peptide has been shown to increase food intake and body adiposity in most species. However, the biological role endogenous Ghr molecular control energy metabolism is far less understood. Mice deficient for either or its receptor (the growth hormone secretagogue receptor, GHS-R1a) seem exhibit enhanced protection against high-fat diet-induced obesity but do not show a substantial metabolic phenotype on standard diet. Here we present first...
We investigated a possible role of the central glucagon-like peptide (GLP-1) receptor system as an essential brain circuit regulating adiposity through effects on nutrient partitioning and lipid metabolism independent from feeding behavior. Both lean diet-induced obesity mice were used for our experiments. GLP-1 (7–36) amide was infused in 2 or 7 d. The expression key enzymes involved measured by real-time PCR Western blot. To test hypothesis that sympathetic nervous may be responsible...
Diet-induced obesity and its serious consequences such as diabetes, cardiovascular disease, cancer are rapidly becoming a major global health threat. Therefore, understanding the cellular molecular mechanisms by which dietary fat causes diabetes is of paramount importance in order to identify preventive therapeutic strategies. Increased intake results high plasma levels triglyceride-rich lipoproteins (TGRL). Tissue uptake TGRL has been shown promote glucose intolerance. We generated mice...
Olfaction is an integral part of feeding providing predictive cues that anticipate ingestion. Although olfactory function modulated by factors such as prolonged fasting, the underlying neural mechanisms remain poorly understood. We recently identified ghrelin receptors in circuits brain. therefore investigated role appetite-stimulating hormone processing rodents and humans, testing hypothesis lowers detection thresholds enhances exploratory sniffing, both being related to food seeking. In...
Surgical interposition of distal ileum into the proximal jejunum is a bariatric procedure that improves metabolic syndrome. Changes in intestinal and hepatic physiology after ileal (transposition) surgery (IIS) are not well understood. Our aim was to elucidate adaptation interposed ileum, which we hypothesized, would lead early bile acid reabsorption thus short circuiting enterohepatic recycling more bowel segments. Rats with diet-induced obesity were randomized IIS, 10 cm repositioned...
The identification of leptin as a mediator body weight regulation provided much initial excitement for the treatment obesity. Unfortunately, monotherapy is insufficient in reversing obesity rodents or humans. Recent findings suggest that amylin able to restore sensitivity and when used combination with enhances loss obese However, uniqueness this therapy remains unclear, we assessed whether co‐administration other loss‐inducing hormones equally restores responsiveness diet‐induced (DIO)...