A5071999830- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Rheumatoid Arthritis Research and Therapies
- Spondyloarthritis Studies and Treatments
- Bariatric Surgery and Outcomes
- Psoriasis: Treatment and Pathogenesis
- Diabetes Treatment and Management
- Autoimmune and Inflammatory Disorders Research
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Genetic Neurodegenerative Diseases
- Adipose Tissue and Metabolism
- Systemic Lupus Erythematosus Research
- Geriatric Care and Nursing Homes
- Pharmacology and Obesity Treatment
- Celiac Disease Research and Management
- Diet, Metabolism, and Disease
- Sleep and Wakefulness Research
- Cytokine Signaling Pathways and Interactions
- Vasculitis and related conditions
- Nutrition, Genetics, and Disease
- Lymphoma Diagnosis and Treatment
- Thermal Regulation in Medicine
- Parkinson's Disease and Spinal Disorders
University of Cincinnati
2010-2023
NHS Lothian
2023
The Huntington Library, Art Museum, and Botanical Gardens
2022
West Lothian Council
2019-2020
NHS Greater Glasgow and Clyde
2013-2019
Glasgow Royal Infirmary
2013-2019
Ithaka Harbors
2015-2018
University of Glasgow
1953-2017
Stobhill Hospital
2007-2016
University of Cincinnati Medical Center
2010-2012
<h3>Importance</h3> Deutetrabenazine is a novel molecule containing deuterium, which attenuates CYP2D6 metabolism and increases active metabolite half-lives may therefore lead to stable systemic exposure while preserving key pharmacological activity. <h3>Objective</h3> To evaluate efficacy safety of deutetrabenazine treatment control chorea associated with Huntington disease. <h3>Design, Setting, Participants</h3> Ninety ambulatory adults diagnosed manifest disease baseline total maximal...
Glucagon-like peptide 1 (GLP-1) is a hormone that released from the gut in response to nutrient ingestion and has range of metabolic effects, including enhancing insulin secretion decreasing food intake. Postprandial GLP-1 greatly enhanced rats humans after some bariatric procedures, vertical sleeve gastrectomy (VSG), been widely hypothesized contribute reduced intake, weight loss, improvements glucose homeostasis VSG. We tested this hypothesis using two separate models receptor deficiency....
Importance The effects of moderate systolic blood pressure (SBP) lowering after successful recanalization with endovascular therapy for acute ischemic stroke are uncertain. Objective To determine the futility lower SBP targets (&amp;lt;140 mm Hg or 160 Hg) compared a higher target (≤180 Hg). Design, Setting, and Participants Randomized, open-label, blinded end point, phase 2, clinical trial that enrolled 120 patients who had undergone at 3 US comprehensive centers from January 2020 to...
Background Multiple questionnaires to screen for psoriatic arthritis (PsA) have been developed but the optimal screening questionnaire is unknown. Objectives To compare three PsA in a head‐to‐head study using CASPAR (the Classification Criteria Psoriatic Arthritis) as gold standard. Methods This recruited from 10 U.K. secondary care dermatology clinics. Patients with diagnosis of psoriasis, not previously diagnosed PsA, were given all questionnaires. All patients who positive on any invited...
Vertical sleeve gastrectomy (VSG) is a restrictive procedure that reduces food intake to produce weight loss. Here we assess volume and nutrient effects on the ingestive behavior of VSG sham surgery animals. Rats given access Ensure or pelleted chow were used determine if liquid foods would adversely affect loss after surgery. Volume studied by altering caloric density Ensure, dietary preferences for fat carbohydrate (sucrose) assessed using two-bottle test. c-Fos was measure neuronal...
Summary Radioimmunoassay estimations of urinary human chorionic gonadotrophin (HCG) were performed on 458 patients who had hydatidiform mole between 1963 and 1972. Whenever possible, assays regularly for two years specimens posted by the patient to a central laboratory. There no deaths in 280 regular assays. About 70 per cent women an invasive trophoblastic lesion following but these lesions resolved spontaneously most cases. Using defined criteria treatment, less than six percent required...
The degree of disability and negative impact on quality life caused by psoriasis psoriatic arthritis are comparable to those ischaemic heart disease, diabetes, depression, cancer.1 Severe associated with an increased risk conditions such as cardiovascular depression.2 3 4 5 Psoriatic is underdiagnosed; about a fifth patients also have arthritis.6 management both may be particularly challenging require close collaboration among several specialties. This article summarises the most recent...
Glucagon-like peptide-1 (GLP-1) is an insulinotropic factor made in the gastrointestinal tract that essential for normal glucose tolerance. Infusion of GLP-1 increases insulin secretion both diabetic and nondiabetic humans. However, degree to which people vary their β-cell sensitivity factors contributing this variability have not been reported.The objective was measure cohorts lean obese subjects across a broad range sensitivity.Insulin measured during clamped hyperglycemia (7.2 mmol/L)...
To identify baseline prognostic indicators of disability at 1 year within a contemporary early inflammatory arthritis inception cohort and then develop clinically useful tool to support patient education decision-making.The Scottish Early Rheumatoid Arthritis (SERA) is multicenter, prospective study patients with newly presenting RA or undifferentiated arthritis. SERA data were analyzed determine predictors (defined as Health Assessment Questionnaire [HAQ] score ≥1) year. Clinical...