A5042743128- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- Eating Disorders and Behaviors
- Body Contouring and Surgery
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Treatment and Management
- Obesity and Health Practices
- Adipokines, Inflammation, and Metabolic Diseases
- Regulation of Appetite and Obesity
- Diabetes Management and Research
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Nuclear Structure and Function
- Biochemical Analysis and Sensing Techniques
- COVID-19 Clinical Research Studies
- Cardiovascular Disease and Adiposity
- Pharmacology and Obesity Treatment
- Esophageal and GI Pathology
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Diet, Metabolism, and Disease
Hospices Civils de Lyon
2016-2025
Laboratoire CarMeN
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Inserm
2014-2025
Institut National des Sciences Appliquées de Lyon
2008-2025
Hôpital Lyon Sud
2015-2024
Institut National des Sciences Appliquées Rouen Normandie
2024
Institut National Polytechnique de Toulouse
2024
Centre de Recherche en Nutrition Humaine Rhône-Alpes
2013-2022
Centre Nantais de Sociologie
2013-2022
Coronavirus disease-2019 (COVID-19) is a life-threatening infection caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. Diabetes has rapidly emerged as major comorbidity for COVID-19 severity. However, phenotypic characteristics of diabetes in patients are unknown. We conducted nationwide multicentre observational study people with hospitalised 53 French centres period 10–31 March 2020. The primary outcome combined tracheal intubation mechanical ventilation...
We investigated a possible role of the central glucagon-like peptide (GLP-1) receptor system as an essential brain circuit regulating adiposity through effects on nutrient partitioning and lipid metabolism independent from feeding behavior. Both lean diet-induced obesity mice were used for our experiments. GLP-1 (7–36) amide was infused in 2 or 7 d. The expression key enzymes involved measured by real-time PCR Western blot. To test hypothesis that sympathetic nervous may be responsible...
Apelin, an adipocyte-secreted factor upregulated by insulin, is increased in adipose tissue (AT) and plasma with obesity. Apelin was recently identified as a new player the control of glucose homeostasis. However, regulation apelin APJ (apelin receptor) expression skeletal muscle relation to insulin resistance or type 2 diabetes not known. Thus we studied AT different mice models obesity diabetic patients. In insulin-resistant high-fat (HF)-fed mice, were compared control. This case highly...
Factors governing microRNA expressions in response to changes of cellular environment are still largely unknown. Our aim was determine whether insulin, the major hormone controlling whole-body energy homeostasis, is involved regulation human skeletal muscle.We carried out comparative (miRNA) expression profiles muscle biopsies before and after a 3-h euglycemic-hyperinsulinemic clamp, with TaqMan low-density arrays. Then, using DNA microarrays, we determined insulin miRNA putative target...
Obesity, through low-grade inflammation, can drive insulin resistance and type 2 diabetes. While infiltration of adipose tissue (AT) with mononuclear cells (MNCs) is well established in obesity, the functional consequences these interactions are less understood. Herein, we cocultured human adipose-derived stem (ASCs) from obese individuals MNCs analyzed their reciprocal behavior. Presence ASCs 1) enhanced interleukin (IL)-17A secretion by Th17 cells, 2) inhibited γ-interferon tumor necrosis...
OBJECTIVE A strong association between genetic variants and obesity was found for the fat mass obesity-associated gene (FTO). However, few details are known concerning expression function of FTO in skeletal muscle patients with metabolic diseases. RESEARCH DESIGN AND METHODS We investigated basal from obese nondiabetic subjects type 1 2 diabetic patients, compared age-matched control subjects, its regulation vivo by insulin, glucose, or rosiglitazone. The further studied myotubes...
Accumulating data suggest a novel role for bile acids (BAs) in modulating metabolic homeostasis. BA treatment has been shown to improve glucose tolerance and increase energy expenditure mice. Here, we investigated the relationship between fasting plasma BAs concentrations parameters humans.Fasting glucose, insulin lipid profile were measured 14 healthy volunteers, 20 patients with type 2 diabetes (T2D), 22 non-diabetic abdominally obese subjects. Insulin sensitivity was also assessed by...
Acquired lipodystrophy is often characterized as an idiopathic subtype of lipodystrophy. Despite suspicion immune-mediated pathology, biomarkers such autoantibodies are generally lacking. Here, we used unbiased proteome-wide screening approach to identify the adipocyte-specific lipid droplet protein perilipin 1 (PLIN1) in a murine model autoimmune polyendocrine syndrome type (APS1). We then tested for PLIN1 human subjects with acquired two independent severe breaks immune tolerance...
<p dir="ltr"><b>Objective: </b>Screening for advanced fibrosis (AF) due to metabolic dysfunction-associated steatotic liver disease (MASLD) is recommended in diabetology. This study aimed compare the performance of non-invasive tests (NITs) and 2-step algorithms detecting patients with high-risk AF requiring referral hepatologists.</p><p dir="ltr"><b>Research Design Methods: </b>A planned interim analysis a<b> </b>prospective multi-center...