A5018886514- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes and associated disorders
- Hormonal Regulation and Hypertension
- Nuclear Structure and Function
- Regulation of Appetite and Obesity
- Diet and metabolism studies
- Pancreatic function and diabetes
- Diabetes Management and Research
- Microbial metabolism and enzyme function
- Adrenal Hormones and Disorders
- Tryptophan and brain disorders
- HIV-related health complications and treatments
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Treatment of Major Depression
- Receptor Mechanisms and Signaling
- Metabolism, Diabetes, and Cancer
- Biochemical Acid Research Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Stress Responses and Cortisol
- HIV Research and Treatment
- Peroxisome Proliferator-Activated Receptors
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Hôpital Saint-Antoine
2015-2024
Sorbonne Université
2015-2024
Inserm
2015-2024
Centre de Recherche Saint-Antoine
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2014-2024
University of Graz
2024
University of Pennsylvania
2024
Sorbonne University Abu Dhabi
2024
Sorbonne Paris Cité
2021-2022
In addition to their role in controlling water and salt homeostasis, recent work suggests that aldosterone mineralocorticoid receptors (MR) may be involved adipocyte biology. This is of particular relevance given the MR as a high-affinity receptor for both mineralocorticoids glucocorticoids. We have thus examined effect on white adipose cell differentiation. When cells are cultured steroid-free medium, promotes acquisition phenotype 3T3-L1 3T3-F442A time-, dose-, MR-dependent manner....
The human leukocyte antigen-A2 (HLA-A2)-restricted zinc transporter 8186-194 (ZnT8186-194) and other islet epitopes elicit interferon-γ secretion by CD8+ T cells preferentially in type 1 diabetes (T1D) patients compared with controls. We show that clonal ZnT8186-194-reactive express private cell receptors display equivalent functional properties T1D healthy individuals. Ex vivo analyses further revealed reactive to ZnT8186-194 circulate at similar frequencies exhibit a predominantly naïve...
Metabolomic approaches are increasingly used to identify new disease biomarkers, yet normal values of many plasma metabolites remain poorly defined. The aim this study was define the "normal" metabolome in healthy volunteers. We included 800 French volunteers aged between 18 and 86, equally distributed according sex, free any medication considered on basis their medical history, clinical examination standard laboratory tests. quantified 185 metabolites, including amino acids, biogenic...
Abstract Background Although some integrase strand transfer inhibitors (INSTIs) promote peripheral and central adipose tissue/weight gain in people with human immunodeficiency virus (PHIV), the underlying mechanism has not been identified. Here, we used simian models to assess impact of INSTIs on tissue phenotype function. Methods Adipocyte size fibrosis were determined biopsies subcutaneous visceral (SCAT VAT, respectively) from 14 noninfected macaques 19 PHIV treated or an INSTI. Fibrosis,...
Aging is associated with central fat redistribution and insulin resistance. To identify age-related adipose features, we evaluated the senescence adipogenic potential of adipose-derived stromal cells (ASCs) from abdominal subcutaneous obtained healthy normal-weight young (<25 years) or older women (>60 years). Increased cell passages young-donor ASCs (in vitro aging) resulted in but not oxidative stress. ASC-derived adipocytes presented impaired adipogenesis no early mitochondrial...
The mineralocorticoid receptor (MR) mediates aldosterone- and glucocorticoid-induced adipocyte differentiation. Drospirenone (DRSP) is a potent synthetic antimineralocorticoid with progestogenic antiandrogenic properties, which widely used for contraception hormone replacement therapy. We investigated its potential role on effects of DRSP were studied in murine preadipocyte cell lines primary cultures human preadipocytes. Differentiation markers mechanisms underlying phenotypic variations...
To maintain bone mass turnover and mineral density (BMD), marrow (BM) mesenchymal stem cells (MSCs) are constantly recruited subsequently differentiated into osteoblasts. HIV-infected patients present lower BMD than non-HIV infected individuals a higher prevalence of osteopenia/osteoporosis. In antiretroviral treatment (ART)-naive patients, encoded HIV proteins represent pathogenic candidates. They released by within BM can impact on neighbouring cells. this study, we tested whether Tat...
Stimulating conversion of white fat to metabolically active adipocytes (beige fat) constitutes a promising strategy against weight gain and its deleterious associated-disorders. We provide direct evidence that prolactin (PRL), best known for actions on the mammary gland, plays pivotal role in energy balance through control adipocyte differentiation fate. Here we show lack receptor (PRLR) causes resistance high-fat-diet-induced obesity due enhanced expenditure increased metabolic rate. Mutant...
Pioglitazone could induce remission in major depression: a meta-analysis Romain Colle,1,* Delphine de Larminat,1,* Samuel Rotenberg,1 Franz Hozer,1 Patrick Hardy,1 Céline Verstuyft,2 Bruno Fève,3,* Emmanuelle Corruble1,* 1Psychiatry Department, Hôpital Bicêtre, INSERM, UMR S1178, University Paris-Sud, Assistance Publique-Hôpitaux Paris, Le Kremlin France; 2Molecular Genetic, Pharmacogenetics and Hormonology INSERM UMR_S1184, Centre IMVA, 3Endocrinology...