A5044943441- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Nuclear Structure and Function
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Genomics and Diagnostics
- Neuroscience and Neuropharmacology Research
- Vasculitis and related conditions
- Chronic Lymphocytic Leukemia Research
- Cholinesterase and Neurodegenerative Diseases
- HIV-related health complications and treatments
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Viral-associated cancers and disorders
- HIV Research and Treatment
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Cervical and Thoracic Myelopathy
- Nicotinic Acetylcholine Receptors Study
- Neuroendocrine Tumor Research Advances
- Soft tissue tumor case studies
- Colorectal and Anal Carcinomas
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
Inserm
2012-2024
Sorbonne Université
2015-2024
Assistance Publique – Hôpitaux de Paris
2014-2024
Centre de Recherche Saint-Antoine
2009-2024
Université Bourgogne Franche-Comté
2024
Hôpital Saint-Antoine
2014-2023
Délégation Paris 5
2022
Université Paris Cité
2016-2022
Institut Pasteur
2022
Hôpital Cochin
2022
Perilipin is the most abundant adipocyte-specific protein that coats lipid droplets, and it required for optimal incorporation release from droplet. We identified two heterozygous frameshift mutations in perilipin gene (PLIN1) three families with partial lipodystrophy, severe dyslipidemia, insulin-resistant diabetes. Subcutaneous fat patients was characterized by smaller-than-normal adipocytes, macrophage infiltration, fibrosis. In contrast to wild-type perilipin, mutant forms of failed...
Mutations that decrease insulin-like growth factor (IGF) and hormone signaling limit body size prolong lifespan in mice. In vertebrates, these somatotropic hormones are controlled by the neuroendocrine brain. Hormone-like regulations discovered nematodes flies suggest IGF signals nervous system can determine lifespan, but it is unknown whether this applies to higher organisms. Using conditional mutagenesis mouse, we show brain receptors (IGF-1R) efficiently regulate development. Partial...
Immune checkpoint (ICK) expression might represent a surrogate measure of tumor-infiltrating T cell (CTL) exhaustion and therefore be more accurate prognostic biomarker for colorectal cancer (CRC) patients than CTL enumeration as measured by the Immunoscore. The ICKs, Th1, CTLs, cytotoxicity-related genes, metagenes, including Immunoscore-like were evaluated in three independent cohorts CRC samples (260 microsatellite instable [MSI], 971 non-MSI). Their associations with patient survival...
•Concordance between MMR IHC (four proteins) and MSI molecular testing (Pentaplex) is superior to 98% in CRC cases•Most discordant cases are related misinterpretation of the tests, which may lead clinical management errors.•Discordant must be reviewed tests repeated because most will reclassified as nondiscordant. BackgroundDNA mismatch repair system deficiency (dMMR) found 15% colorectal cancers (CRCs). Two methods used determine dMMR, immunohistochemistry (IHC) proteins microsatellite...
•ChallengES tumor mutation burden (TMB) and MSIsensor for predicting response to immunotherapy in MSI mCRC.•Demonstration that misdiagnoses lead a false ability of TMB predict ICI resistance mCRC.•Identification validation DNA RNA signatures predictive these patients with mCRC MSI.•Evidence fibrosis signature associated functional mCRC. BackgroundMismatch repair-deficient (dMMR) tumors displaying microsatellite instability (MSI) represent paradigm the success immune checkpoint inhibitor...
To achieve a better understand of the pathophysiology HIV-related lipoatrophy, we compared mRNA expression adipocytokines in fat samples from patients and healthy HIV-seronegative controls together with morphology studied relationship between changes morphology, adipocytokine expression, markers adipose tissue differentiation whole body insulin sensitivity.Cross-sectional analytical study.The transcriptional factors 26 peripheral lipoatrophy (all under anti-retroviral therapy associating...
BackgroundCrohn's disease (CD) is associated with an increased risk of small bowel adenocarcinoma (SBA). However, there are no guidelines for the screening and early diagnosis SBA. Colorectal cancer chronic colitis arises from dysplasia. High-risk patients benefit surveillance colonoscopies aimed to detect The dysplasia–carcinoma sequence remains poorly documented in CD-associated Moreover, molecular data about SBA complicating CD dysplasia very limited. We therefore assessed several key...
Cholinergic neurons were studied by immunohistochemistry with an antiserum against human choline acetyltransferase in the caudate nucleus, putamen, and ventral striatum (including nucleus accumbens) of three patients Alzheimer disease control subjects. Immunoreactive cell bodies mapped counted. In disease, a 60% decrease number cholinergic was observed, whereas putamen values for subjects similar. To determine whether all affected, neuropeptide Y-containing also immunostained, mapped, The...
Some LMNA mutations responsible for insulin-resistant lipodystrophic syndromes are associated with peripheral subcutaneous lipoatrophy and faciocervical fat accumulation. Their pathophysiologic characteristics unknown. We compared histologic, immunohistologic, ultrastructural, protein expression features of enlarged cervical adipose tissue (scAT) obtained during plastic surgery from four patients p.R482W, p.R439C, or p.H506D versus eight control subjects, buffalo humps five HIV infection...
Every colorectal cancer (CRC) patient should be tested for microsatellite instability (MSI, a marker defective DNA mismatch repair) as first screen Lynch syndrome (LS). In this study, we investigated whether it may possible to improve the detection of MSI in CRC. We examined HT17 repeat (critical correct splicing chaperone HSP110) might constitute superior diagnosis phenotype patients with CRC compared standard panel markers (pentaplex).The polymorphism was analysed germline from 1037...
Abstract Despite the progress made in our understanding of biology neurofibromatosis (NF), long-term clinical outcome for affected patients has not changed significantly past decades, and both NF1 NF2 are still associated with a significant morbidity decreased life span. A number murine models have been generated to aid study NF tumor development targeted therapies patients. single, universal pathological classification lesions these is essential validation models, their analysis comparison...
Epidermal growth factor receptor (EGFR) and VEGF(R) signaling show extensive cross-talk, providing a rationale for joint targeting of the two pathways. However, combinations monoclonal antibodies (mAb) EGFR VEGF showed disappointing activity in patients with colorectal cancer (CRC). We speculated that inhibition surface receptors ligands might only partly prevent oncogenic whereas small-molecule tyrosine kinase inhibitors (TKI) would also influence intracellular signaling.Mice CRC xenografts...