Jean Closset

ORCID: 0000-0001-5838-0243
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About
Contact & Profiles
Research Areas
  • Pancreatic and Hepatic Oncology Research
  • Esophageal and GI Pathology
  • Bariatric Surgery and Outcomes
  • Pancreatitis Pathology and Treatment
  • Growth Hormone and Insulin-like Growth Factors
  • Gallbladder and Bile Duct Disorders
  • Neuroendocrine Tumor Research Advances
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Cancer Genomics and Diagnostics
  • Sexual Differentiation and Disorders
  • Gastroesophageal reflux and treatments
  • Gastric Cancer Management and Outcomes
  • Body Contouring and Surgery
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Renal cell carcinoma treatment
  • Gastrointestinal disorders and treatments
  • Diet and metabolism studies
  • Liver Disease and Transplantation
  • Glycosylation and Glycoproteins Research
  • Organ Transplantation Techniques and Outcomes
  • Pediatric Hepatobiliary Diseases and Treatments
  • Sperm and Testicular Function
  • Dysphagia Assessment and Management
  • Abdominal Trauma and Injuries
  • Monoclonal and Polyclonal Antibodies Research

Erasmus Hospital
2013-2024

Université Libre de Bruxelles
2012-2024

Mie University Hospital
2023

Centre Hospitalier Universitaire Brugmann
2018

University of California, Irvine
2018

University of California, Los Angeles
2018

University of Liège
1994-2010

St. Elisabeth Hospital
2007

Centre Hospitalier Universitaire de Liège
1977-2005

Medico
2000-2001

The purpose of our study was to determine prospectively the value helical CT and various signs ischemia in context acute bowel obstruction.All patients seen over a 3-year period with diagnosis small-bowel obstruction were included. There 144 examinations 142 patients. Images interpreted consensus by fellow an experienced gastrointestinal radiologist. Attention focused on presence following strangulation ischemia: reduced enhancement wall, mural thickening, mesenteric fluid, congestion small...

10.2214/ajr.175.6.1751601 article EN American Journal of Roentgenology 2000-12-01

A 67000 Mr bovine pregnancy-associated glycoprotein (bPAG) has been isolated from fetal cotyledons and purified to homogeneity by HPLC. The purification was monitored a double immunodiffusion test RIA in conjunction with an antiserum raised against crude fraction of placenta-specific antigens. molecular weight bPAG estimated be SDS-PAGE. isoelectric points (pI) the four isoforms, determined high-resolution analytical electrofocusing polyacrylamide gel, were 4.4, 4.6, 5.2, 5.4. carbohydrate...

10.1095/biolreprod45.1.1 article EN Biology of Reproduction 1991-07-01

Chemokines and their receptors are involved in tumourigenicity clinicopathological significance of chemokines receptor expression pancreatic adenocarcinoma (PA) is not fully understood. This study was conducted to determine patients' outcome according the expressions CXCR4, CXCR7 HIF-1α after resection PA. Immunohistochemistry for as well cell proliferative index (Ki-67) 71 resected (R0) PA 48 related lymph nodes (LN) using tissue microarray. CXCR4 were positively correlated suggesting a...

10.1038/sj.bjc.6605020 article EN cc-by-nc-sa British Journal of Cancer 2009-04-07

Clusterin is, in its major form, a secreted heterodimeric disulfide-linked glycoprotein (75–80 kDa). It was first linked to cell death the rat ventral prostate after androgen deprivation. Recent studies have demonstrated that overexpression of clusterin prostatic cells protects them against tumor necrosis factor-α (TNFα)-induced apoptosis. However details this survival mechanism remain undefined. Here, we investigate how prevents from undergoing TNFα-induced We established double-stable line...

10.1074/jbc.m800403200 article EN cc-by Journal of Biological Chemistry 2008-03-06

Corrected by: Transoral gastroplasty is safe, feasible, and induces significant weight loss in morbidly obese patients: results of the second human pilot studyEndoscopy 2008; 40(06): 537-537DOI: 10.1055/s-2008-1077370 See also: Commentaire de travail C. Moreno et al., pp. 406Endoscopy 40(05): 455-455DOI: 10.1055/s-0032-1306833

10.1055/s-2007-995748 article EN Endoscopy 2008-05-05

To prospectively determine whether dynamic contrast material-enhanced (DCE) magnetic resonance (MR) quantitative parameters correlate with fibrosis and microvascular density (MVD) in malignant benign solid pancreatic focal lesions nontumoral tissue.The institutional review board approved the study; written informed consent was obtained. DCE MR performed 28 patients surgically resectable lesions. derived from one-compartment (OC) (transfer rate constant [K(trans)] distribution fraction [ƒ])...

10.1148/radiol.11103515 article EN Radiology 2011-08-19

Opioid-free anesthesia (OFA) is associated with significantly reduced cumulative postoperative morphine consumption in comparison opioid-based (OBA). Whether OFA feasible and may improve outcomes pancreatic surgery remains unclear.Perioperative data from 77 consecutive patients who underwent resection were included retrospectively reviewed. Patients received either an OBA intraoperative remifentanil (n = 42) or 35). a combination of continuous infusions dexmedetomidine, lidocaine,...

10.1186/s12871-021-01551-y article EN cc-by BMC Anesthesiology 2022-01-04

In adhesive small bowel obstruction, the early recognition of complications such as strangulation or volvulus is essential to choose between surgical conservative initial treatment. The objective this study was determine prospectively contribution computed tomography (CT) decision making in management these patients.Patients with suspected obstruction had CT at admission. Patients signs and/or clinical peritoneal irritation underwent urgent surgery; other patients treatment.Fifty-four were...

10.1046/j.1365-2168.1998.00813.x article EN British journal of surgery 1998-08-01

<b>Background and study aims:</b> Paraduodenal pancreatitis is histologically well defined but its epidemiology, natural history, connection with chronic are not completely understood. The aim of this was to review the endoscopic medical management paraduodenal pancreatitis. <b>Patients methods:</b> Medical records all patients diagnosed by magnetic resonance cholangiopancreatography (MRCP) or ultrasonography (EUS) between 1995 2010 were retrospectively reviewed. Clinical features, imaging...

10.1055/s-0034-1365719 article EN Endoscopy 2014-05-16

We have studied dose-dependent effects of highly purified human PRL (39 IU/mg) on the testis immature (22-day-old) hypophysectomized rats daily supplemented for 7 days with 2, 10, or 30 micrograms hormone. Dose-dependent stimulation was observed all parameters: weight (1.6- and 2-fold above control 10 PRL), basal hCG-stimulated testosterone (14- 21-fold), intratesticular (7- 21-fold) estradiol (1.2- 1.5-fold), LH receptor concentration (1.8- 2.5-fold), in vitro pregnenolone production by...

10.1210/endo.130.2.1733717 article EN Endocrinology 1992-02-01

Since insulin-like growth factors I (IGF-I) and II (IGF-II) appeared involved in paracrine or autocrine regulation of both cell multiplication differentiation the rat testis, we have investigated pituitary hormonal dependence IGF-I IGF-II mRNA production testis immature hypophysectomized rats (22 days old) supplemented with highly purified FSH, LH, GH PRL. Our data show that testicular expression as measured by dot-blot hybridization, is increased FSH treatments 7-, 6-, 4-fold, respectively,...

10.1210/mend-3-7-1125 article EN Molecular Endocrinology 1989-07-01

BACKGROUND Goal-directed fluid therapy (GDFT) has been associated with improved patient outcomes. However, implementation of GDFT protocols remains low despite growing published evidence and the recommendations multiple regulatory bodies in Europe. We developed a closed-loop-assisted management system linked to pulse contour monitor assist anaesthesiologists applying GDFT. OBJECTIVE To assess impact our closed-loop patients undergoing major abdominal surgery an academic hospital without...

10.1097/eja.0000000000000827 article EN European Journal of Anaesthesiology 2018-05-11
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