A5062356516- Glioma Diagnosis and Treatment
- Galectins and Cancer Biology
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Meningioma and schwannoma management
- AI in cancer detection
- Brain Metastases and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Nephrotoxicity and Medicinal Plants
- Cancer Cells and Metastasis
- Cell Image Analysis Techniques
- Sarcoma Diagnosis and Treatment
- S100 Proteins and Annexins
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Signaling Pathways in Disease
- Neuropeptides and Animal Physiology
Grand Charleroi Hospital
2024-2025
VIB-UAntwerp Center for Molecular Neurology
2014-2024
Université Libre de Bruxelles
2015-2024
Erasmus Hospital
2015-2024
Centre Hospitalier Interrégional Edith Cavell
2020-2024
Centre Hospitalier Universitaire de Tivoli
2020-2024
Hôpital Universitaire Dupuytren
2024
Centre Hospitalier Universitaire de Liège
2018-2023
Creative Commons
2023
Queen Mary University of London
2023
Post-mortem studies can provide important information for understanding new diseases and small autopsy case series have already reported different findings in COVID-19 patients.We evaluated whether some specific post-mortem features are observed these patients if changes related to the presence of virus organs. Complete macroscopic microscopic autopsies were performed on organs 17 non-survivors. Presence SARS-CoV-2 was with immunohistochemistry (IHC) lung samples real-time...
Abstract Netrin-1 is upregulated in cancers as a protumoural mechanism 1 . Here we describe netrin-1 upregulation majority of human endometrial carcinomas (ECs) and demonstrate that blockade, using an anti-netrin-1 antibody (NP137), effective reduction tumour progression EC mouse model. We next examined the efficacy NP137, first-in-class single agent, Phase I trial comprising 14 patients with advanced EC. As best response observed 8 stable disease (8 out 14, 57.1%) objective RECIST v.1.1...
Chinese-herb nephropathy (CHN) is a rapidly progressive renal fibrosis associated with the intake of Chinese herb (Aristolochia fangchi) containing nephrotoxic and carcinogenic aristolochic acids (AA). This study attempted to reproduce main features human CHN (renal failure, tubular atrophy, interstitial fibrosis) in rat model similar that cyclosporin-induced nephropathy. Salt-depleted male Wistar rats received daily subcutaneous injections either 1 mg/kg body wt AA (low-dose group), 10...
Gemcitabine is a promising adjuvant treatment for patients with resected pancreatic adenocarcinoma and its use in combination radiotherapy under exploration. Human equilibrative nucleoside transporter 1 (hENT1) human concentrative (hCNT) 3 are the major transporters responsible 2',2'-difluoro-2-deoxycytidine (gemcitabine) uptake into cells. The aim of this study was to determine patients' outcome according expression hENT1 hCNT3 tumoral cells after postoperative gemcitabine-based...
Object. Positron emission tomography with l -[methyl-11C]methionine (MET-PET) provides information on the metabolism of gliomas. The aim this study was to determine predictive value MET-PET in treatment patients Methods. Since 1992, 85 a World Health Organization (WHO) classification—verified glioma underwent PET studies which MET injected before (74 cases) or after (11 cases). Analysis data conducted by same investigator using two scales: qualitative visual grading scale and quantitative...
We show that high-grade astrocytic tumors with high levels of galectin-1 expression are associated dismal prognoses. The immunohistochemical analysis human U87 and U373 glioblastoma xenografts from the brains nude mice revealed a higher level in invasive areas rather than non-invasive xenografts. Nude intracranially grafted or cells constitutively expressing low (by stable transfection an vector containing antisense mRNA galectin-1) had longer survival periods those normal galectin-1....
Chemokines and their receptors are involved in tumourigenicity clinicopathological significance of chemokines receptor expression pancreatic adenocarcinoma (PA) is not fully understood. This study was conducted to determine patients' outcome according the expressions CXCR4, CXCR7 HIF-1α after resection PA. Immunohistochemistry for as well cell proliferative index (Ki-67) 71 resected (R0) PA 48 related lymph nodes (LN) using tissue microarray. CXCR4 were positively correlated suggesting a...
<b>BACKGROUND AND PURPOSE:</b> MR imaging–based apparent diffusion coefficient (ADC) and regional cerebral blood volume (rCBV) measurements have been related respectively to both cell microvessel density in brain tumors. However, because of the high degree heterogeneity gliomas, a direct correlation between these histopathologic features is required. The purpose this study was correlate regionally ADC rCBV values with by using coregistered imaging stereotactic biopsies. <b>MATERIALS...
Microsatellite instability (MSI) accounts for 15% of all colorectal tumours. Several specific clinicopathologicals (e.g., preference the proximal colon over distal colon, improved prognosis and altered response to chemotherapeutics) are described this subset This study aimed analyse morphological, inflammatory angiogenic features MSI vs microsatellite stable (MSS) Twenty-seven MSS 29 MSI, TNM stage matched, tumours were selected from archive Department Pathology, UZ Leuven. Morphology was...
Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-catabolising enzyme that induces immune tolerance by modulating T-cell responses. Carcinomas may create an immunosuppressive state via IDO1 expression. Here we examined possible contribution of on this phenomenon and investigated whether has prognostic value in colorectal cancer (CRC). expression was quantitative PCR western blotting three colon cell lines, basal after interferon (IFN)-γ stimulation. Semi-quantitative immunohistochemistry...
Aim Accumulating evidence suggests that extracellular galectin-1 and galectin-3 promote angiogenesis. Increased expression of and/or has been reported to be associated with tumour progression. Thus, it is critical identify their influence on Methods We examined the individual combined effects endothelial cell (EC) growth tube formation using two EC lines, EA.hy926 HUVEC. The activation vascular factor receptors (VEGFR1 VEGFR2) was determined by ELISA Western blots. evaluated VEGFR1 VEGFR2...