A5038626624- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Neuroblastoma Research and Treatments
- Pituitary Gland Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Cancer, Hypoxia, and Metabolism
- Adrenal and Paraganglionic Tumors
- Gastrointestinal disorders and treatments
- Chemokine receptors and signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Cancer, Lipids, and Metabolism
- Hormonal Regulation and Hypertension
- Pancreatic function and diabetes
- IgG4-Related and Inflammatory Diseases
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Gastric Cancer Management and Outcomes
- Soft tissue tumor case studies
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic factors in colorectal cancer
- Ovarian cancer diagnosis and treatment
- Cell Adhesion Molecules Research
- Liver physiology and pathology
Université Paris Cité
2016-2025
Inserm
2016-2025
Assistance Publique – Hôpitaux de Paris
2016-2025
Hôpital Bichat-Claude-Bernard
2016-2025
Hôpital Beaujon
2015-2025
Centre National de la Recherche Scientifique
2005-2025
Centre de Recherche sur l'Inflammation
2014-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2008-2025
Université Claude Bernard Lyon 1
2001-2024
Bicêtre Hospital
2021-2024
The need for standards in the management of patients with endocrine tumors digestive system prompted European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held Frascati (Rome) and based on recently published ENETS guidelines diagnosis treatment neuroendocrine (NET). Here, we report tumor–node–metastasis proposal foregut NETs stomach, duodenum, pancreas that designed, discussed, consensually approved at this conference. In addition, working...
Criteria for the staging and grading of neuroendocrine tumors (NETs) midgut hindgut origin were established at second Consensus Conference in Frascati (Rome) organized by European Neuroendocrine Tumor Society (ENETS). The proposed tumor–node–metastasis (TNM) classifications are based on recently published ENETS Guidelines Diagnosis Treatment gastroenteropancreatic NETs follow our previous proposal foregut tumors. new TNM ileum, appendix, colon, rectum, system designed, discussed,...
ENETS Consensus Guidelines for the Management of Patients with Liver and Other Distant Metastases from Neuroendocrine Neoplasms Foregut, Midgut, Hindgut, Unknown Primary
Both the European Neuroendocrine Tumor Society (ENETS) and International Union for Cancer Control/American Joint Committee/World Health Organization (UICC/AJCC/WHO) have proposed TNM staging systems pancreatic neuroendocrine neoplasms. This study aims to identify most accurate useful system The included 1072 patients who had undergone previous surgery their cancer which at least 2 years of follow-up from 1990 2007 was available. Data on 28 variables were collected, performance two compared...
tional.However, classified as G1 or G2, Si-NENs are often discovered at an advanced disease stage -regional (36%) and distant metastasis (48%) present -and percutaneous biopsy of a liver lesion is the diagnostic procedure performed [2,7] .Previous ENETS guidelines [1, 8, 9] have discussed extensively clinical symptomology, diagnosis treatment localized, regionalized well Si-NENs.This fourth edition update third version for management patients with published in 2012 [1] order to further...
Chronic obstruction of the common bile duct may cause hepatic fibrosis and secondary biliary cirrhosis.
Data on gastroenteropancreatic neuroendocrine neoplasms (NEN) G3 (well-differentiated tumors (NET G3) and carcinoma (NEC)) are limited. We retrospectively study patients with NET NEC from eight European centers. examined included clinical pathological characteristics at diagnosis, therapies outcomes. Two hundred four were analyzed (37 167 NEC). Median age was 64 (21-89) years. Tumor origin pancreas (32%) colon-rectum (27%). The primary tumor resected in 82 (40%) patients. Metastatic disease...
Recent data from the German NET registry have revealed that approximately one third of cases reported between 2000 and 2006 lack a documented histopathological diagnosis, in even more tentative diagnosis was not confirmed by using neuroendocrine markers, nor proliferation determined Ki67/MIB1 [Plöckinger, unpubl.data].
Abstract BACKGROUND: Prognostic classification of neuroendocrine tumor (NET) patients is difficult due to the complexity current systems. A recent proposal for a tumor‐node‐metastasis (TNM) and grading system based on proliferative fraction proved valid in NETs foregut origin. The purpose this study was test efficacy TNM staging midgut hindgut NETs. METHODS: Two hundred seventy with histologically proven were investigated. Epidemiological, clinicopathological, tumor‐specific data at initial...
In adult humans, the follicle-stimulating hormone (FSH) receptor is expressed only in granulosa cells of ovary and Sertoli testis. It minimally by endothelial gonadal blood vessels.We used immunohistochemical immunoblotting techniques involving four separate FSH-receptor-specific monoclonal antibodies that recognize different FSH epitopes situ hybridization to detect tissue samples from patients with a wide range tumors. Immunoelectron microscopy was mouse tumors.In all 1336 examined, tumors...
Neuroendocrine neoplasms (NEN) of the appendix are a relatively frequent subgroup NEN with an approximate incidence rate 0.15-0.6/100,000/year and slight female preponderance in Western series [1,2,3,4,5,6,7,8,9,10,11,12]. Although frequently reported [13], most cases early stage [12,13,14]. The has increased more recent years [1,6]; however, overall is probably roughly within same range between different races, although some differences have been [1,12,15,16,17,18]. Furthermore, common...
The European Neuroendocrine Tumor Society (ENETS) proposed standard of care guidelines for pathology in 2009. Since then, profound changes the classification have been made, dividing neuroendocrine neoplasia (NEN) into well-differentiated tumors (NET) and poorly differentiated carcinomas (NEC) 2010 WHO classification. 7th edition TNM (2009) included NEN first time, widely adapting ENETS proposals but with some differences NEC NET pancreas appendix. Therapy gastroenteropancreatic were updated...
Abstract Purpose: The roles of intravisceral and subcutaneous fat are unknown, the prevalence precancerous lesions in obese patients was never evaluated. This study aims to assess frequency severity pancreatic intraepithelial neoplasia (PanIN) correlate pathologic findings with metabolic abnormalities, type fat, fatty infiltration. Experimental Design: Normal tissue from surgical specimens analyzed. Fatty infiltration fibrosis intra- extralobular locations PanIN were assessed. General...
This ENETS guidance paper, developed by a multidisciplinary working group, provides up-to-date and practical advice on the diagnosis management of digestive neuroendocrine carcinoma, based recent developments study results. These recommendations aim to pave road for more standardized care our patients resulting in improved outcomes. Prognosis is generally poor NEC, most are advanced at median survival metastatic disease 11-12 months. Surgery can be benefit localized after extensive...
Guidelines| August 28 2009 ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors: Biochemical Markers Subject Area: Endocrinology , Neurology and Neuroscience Dermot O'Toole; O'Toole Department Gastroentereology Clinical Medicine, St. James's Hospital Trinity College, Dublin, Ireland; Search other works by this author on: This Site PubMed Google Scholar Ashley Grossman; Grossman Bartholomew, West Smithfield, London, UK; David Gross; Gross Metabolism, Hadassah...
Tumour-associated angiogenesis is partly regulated by the hypoxia-inducible factor (HIF) pathway. Endocrine tumours are highly vascularised and molecular mechanisms of their not fully delineated. The aim this study to evaluate expression HIF-related molecules in a series patients with pancreatic endocrine (PETs). vascular endothelial growth (VEGF), HIF-1alpha, HIF-2alpha carbonic anhydrase 9 (CA9) was examined immunohistochemistry 45 PETs compared microvascular density (MVD), proliferation,...
To prospectively correlate multidetector computed tomographic (CT) perfusion measurement of pancreatic endocrine tumors with tumor microvascular density (MVD) assessed by using histologic techniques and to determine whether CT parameters differ between grades.Institutional review board approval informed consent were obtained. Thirty-six patients (15 men, 21 women; mean age, 53 years; range, 18-78 years) resectable underwent presurgical dynamic CT. Twenty-eight (78%) 36 included in the study...
It has been suggested that microadenomatosis of the endocrine pancreas is a hallmark multiple neoplasia type 1 syndrome (MEN1). This study attempts to elucidate relationship between pancreatic and MEN1 von Hippel-Lindau (VHL) syndromes. Pancreatic tissue specimens from 37 patients (with either or syndrome) were analyzed using immunohistochemistry, confocal laser scanning microscopy, morphometric methods. The VHL status assessed on basis clinical criteria (all patients) PCR-based mutational...