A5035836720- Metabolism and Genetic Disorders
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- Adrenal Hormones and Disorders
- Hormonal Regulation and Hypertension
- Congenital Heart Disease Studies
- Neuroblastoma Research and Treatments
- Diet and metabolism studies
- Pulmonary Hypertension Research and Treatments
- Autoimmune Bullous Skin Diseases
- Bone health and treatments
- Immunodeficiency and Autoimmune Disorders
- Thyroid Cancer Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Thyroid Disorders and Treatments
- Diabetes and associated disorders
- Growth Hormone and Insulin-like Growth Factors
- Glycogen Storage Diseases and Myoclonus
- Epilepsy research and treatment
- Dermatological and Skeletal Disorders
- Mitochondrial Function and Pathology
- Eosinophilic Disorders and Syndromes
- Platelet Disorders and Treatments
Fox Chase Cancer Center
2019-2024
University of Stuttgart
2024
University of Florida
2023-2024
Jacksonville University
2024
Temple University Health System
2024
Capgemini (Netherlands)
2024
Kantonsspital Graubünden
2024
University of Mississippi Medical Center
2011-2023
University of Tennessee Health Science Center
2013-2023
University of Konstanz
2023
The deleterious effects of ethanol on the developing human brain are poorly understood. Here it is reported that ethanol, acting by a dual mechanism [blockade N-methyl-D-aspartate (NMDA) glutamate receptors and excessive activation GABA(A) receptors], triggers widespread apoptotic neurodegeneration in rat forebrain. Vulnerability coincides with period synaptogenesis, which humans extends from sixth month gestation to several years after birth. During this period, transient exposure can...
Cushing's syndrome (CS) is a disorder associated with significant morbidity and mortality due to prolonged exposure high cortisol concentrations. Our objective was evaluate the safety efficacy of mifepristone, glucocorticoid receptor antagonist, in endogenous CS. We conducted 24-wk multicenter, open-label trial after failed multimodality therapy at 14 U.S. academic medical centers three private research centers. Participants included 50 adults CS type 2 diabetes mellitus/impaired glucose...
Germline mutations in the MEN1 gene predispose to multiple endocrine neoplasia type 1 (MEN1) syndrome, but up 20-25% of clinical cases, no can be found. Recently, a germline mutation CDKN1B gene, encoding p27(Kip1), was reported one suspected family with two acromegalic patients.Our objective evaluate role CDKN1B/p27(Kip1) human tumor predisposition patients clinically testing negative for as well familial and sporadic acromegaly/pituitary adenoma patients.Genomic DNA analyzed by PCR...
It has been suggested that microadenomatosis of the endocrine pancreas is a hallmark multiple neoplasia type 1 syndrome (MEN1). This study attempts to elucidate relationship between pancreatic and MEN1 von Hippel-Lindau (VHL) syndromes. Pancreatic tissue specimens from 37 patients (with either or syndrome) were analyzed using immunohistochemistry, confocal laser scanning microscopy, morphometric methods. The VHL status assessed on basis clinical criteria (all patients) PCR-based mutational...
Patients recovering from COVID-19 may have persistent debilitating symptoms requiring long term support through individually tailored cardiopulmonary and psychological rehabilitation programs. Clinicians need to be aware about the likely long-term complications their diagnostic assessments help identify any occult problems additional help. Endocrinological evaluations should considered as part of armamentarium in management such individuals with diligent cognizance involvement...
Vitamin D deficiency is widely prevalent across all ages, races, geographical regions, and socioeconomic strata. In addition to its important role in skeletal development calcium homeostasis, several recent studies suggest association with diabetes, hypertension, cardiovascular disease, certain types of malignancy, immunologic dysfunction. Here, we review the current evidence regarding an between vitamin hypertension clinical epidemiological studies. We also look into plausible biological...
Pituitary effects of long-term therapy with mifepristone, a glucocorticoid receptor antagonist, in Cushing's disease (CD) patients are not well understood.Our objective was to report changes ACTH and pituitary magnetic resonance imaging (MRI) findings during use mifepristone CD patients.The Study the Efficacy Safety Mifepristone Treatment Endogenous Syndrome (SEISMIC) 24-week, open-label study its extension (LTE) is multicenter U.S. study.Forty-three (mean age 45.3 years) were enrolled...
Maternal vitamin D deficiency has been proposed as a risk factor for preeclampsia, but no significant studies have conducted to evaluate its relationship with eclampsia. Our goal in this study was assess the prevalence and potential of both preeclampsia eclampsia Bangladesh. Using case-control design, we measured serum 25(OH)D levels pregnant women receiving care at Dhaka Medical College Hospital (n=33), (n=79), normal pregnancy (controls, n=76). Odds developing were calculated using...
Multicentric insulinoma disease was characterized with regard to its histopathology, multiple endocrine neoplasia type 1 (MEN1) status, precursor lesions, and the risk of hyperinsulinemic hypoglycemia recurrence.Fourteen patients multicentric were compared 267 sporadic familial insulinomas. The tumors classified according World Health Organization (WHO) criteria. MEN1 status defined clinically by germline mutation analysis. Detection gene locus performed using fluorescence in situ...
Germline mutations in AIP have been recently shown to cause pituitary adenoma predisposition (PAP). Subsequently, many intragenic germline reported, both familial and sporadic settings.Our objective was evaluate the possible contribution of large genomic deletions, an important mutation type tumor syndromes, PAP.Here, we applied multiplex ligation-dependent probe amplification assay examine whether or MEN1 alterations account for a subset PAP cases.The study performed on cases European...