A5007617070- Thyroid Cancer Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Neuroendocrine Tumor Research Advances
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Glycogen Storage Diseases and Myoclonus
- Thyroid and Parathyroid Surgery
- Pituitary Gland Disorders and Treatments
- Head and Neck Anomalies
- Erythrocyte Function and Pathophysiology
- Ion channel regulation and function
- BRCA gene mutations in cancer
- Diabetes and associated disorders
- Lysosomal Storage Disorders Research
- Genetic factors in colorectal cancer
- Metabolism and Genetic Disorders
- Receptor Mechanisms and Signaling
- Carbohydrate Chemistry and Synthesis
- Adrenal and Paraganglionic Tumors
- Congenital Heart Disease Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Regulation of Appetite and Obesity
- Eosinophilic Esophagitis
- Adrenal Hormones and Disorders
University of Calgary
2016-2025
University Hospital in Halle
2023
University Hospital Leipzig
2003-2022
Cancer Institute (WIA)
2016-2021
Calgary Laboratory Services
2021
Alberta Bible College
2016-2019
Leipzig University
2009-2018
Institute of Cancer Research
2018
Massachusetts General Hospital
2015
Scope
2015
Pituitary adenomas are common in the general population, and understanding their molecular basis is of great interest. Combining chip-based technologies with genealogy data, we identified germline mutations aryl hydrocarbon receptor interacting protein (AIP) gene individuals pituitary adenoma predisposition (PAP). AIP acts cytoplasmic retention latent form also has other functions. In a population-based series from Northern Finland, two account for 16% all patients diagnosed secreting growth...
Cervical ultrasound scanning (US) is considered a key examination, by all major thyroid and endocrine specialist societies for the postoperative follow-up of cancer patients to assess risk recurrence. Neck US imaging readily available, non-invasive, relatively easy perform, cost-effective, can guide diagnostic therapeutic procedures with low complication rates. Its main shortcoming its operator-dependency. Because pivotal role in care patients, European Thyroid Association convened panel...
AIP mutations (AIPmut) give rise to a pituitary adenoma predisposition that occurs in familial isolated adenomas and less often sporadic cases. The clinical therapeutic features of AIPmut-associated have not been studied comprehensively.The objective the study was assess clinical/therapeutic characteristics AIPmut adenomas.This an international, multicenter, retrospective case collection/database analysis.The conducted at 36 tertiary referral endocrine genetics departments.Patients included...
With the widespread use of sensitive imaging techniques, which include neck visualization, a conspicuous number thyroid nodules emerge and demand attention. Most lesions are benign, asymptomatic, do not warrant treatment. In case cancer diagnosis, most small, intrathyroidal indolent neoplasms that can safely be managed conservatively. There is pronounced need for more cost-effective, risk-adapted approaches to management this highly prevalent condition, taking wishes patient into...
Recently, it has been shown that the fat‐derived factor adiponectin is downregulated in insulin resistance and obesity replenishment of this adipocytokine reverses mice. Growing evidence, on other hand, suggests raised levels catecholamines due to increased activity sympathetic nervous system are an integral part development resistance. To clarify whether might exert their resistance‐inducing effects at least partly via downregulation gene expression, 3T3‐L1 adipocytes were treated with...
Objective : Subclinical chronic inflammation could be a unifying factor linking type 2 diabetes (T2D) and atherosclerosis. The beneficial effects of physical activity on reduced risk coronary heart disease at least in part mediated by improved markers inflammation. Research design methods aim this study was to determine the effect 4 weeks training plasma concentrations interleukin (IL)-6, C-reactive protein (CRP), adiponectin IL-10 60 individuals with normal glucose tolerance, impaired...
Abnormal glucose tolerance is associated with subclinical chronic inflammation in patients type 2 diabetes. The aim of this study was to investigate whether plasma concentrations inflammatory markers are measures obesity, insulin sensitivity, and hyperglycemia. IL-6, adiponectin, CRP, IL-10 were evaluated 142 a wide range sensitivity tolerance. In parallel the impairment tolerance, there significant increase decrease adiponectin concentrations. There correlations between all % body fat,...
Pituitary adenomas are common neoplasms of the anterior pituitary gland. Germ-line mutations in aryl hydrocarbon receptor-interacting protein ( AIP ) gene cause adenoma predisposition (PAP), a recent discovery based on genetic studies Northern Finland. In this population, founder mutation explained significant proportion all acromegaly cases. Typically, PAP patients were young age at diagnosis but did not display strong family history adenomas. To evaluate role susceptibility other...
Recently, visfatin was characterized as a novel adipo-cytokine that is upregulated in obesity and exerts insulin-mimetic effects various tissues. To clarify expression regulation of this adipocytokine, mRNA measured by quantitative real-time reverse transcription-polymerase chain reaction 3T3-L1 adipocytes during adipogenesis after treatment with hormones known to alter insulin sensitivity. Visfatin about 6-fold higher vitro compared epididymal fat vivo increased adipogenic conversion more...
Molecular fine-needle aspiration (FNA) cytology diagnostics has the potential to address inherent limitation of FNA which is an indeterminate (atypia undetermined significance/follicular lesion significance follicular neoplasm) cytology. Because emerging role molecular diagnostics, European Thyroid Association convened a panel international experts review methodological aspects, indications, results, and limitations diagnostics. The reviewed evidence for diagnostic value mutation assessment...