A5055086811- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- BRCA gene mutations in cancer
- Thyroid Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Radiation Dose and Imaging
- Cancer-related Molecular Pathways
- Growth Hormone and Insulin-like Growth Factors
- MicroRNA in disease regulation
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer-related gene regulation
- Neuroblastoma Research and Treatments
- Advances in Oncology and Radiotherapy
- Genetic factors in colorectal cancer
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Adrenal and Paraganglionic Tumors
- Renal and related cancers
- S100 Proteins and Annexins
- Global Cancer Incidence and Screening
- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
Sapienza University of Rome
2016-2025
Policlinico Umberto I
2011-2024
University of Naples Federico II
2023
Bambino Gesù Children's Hospital
2022
Johns Hopkins Medicine
2015
Johns Hopkins University
2015
Weatherford College
2011-2014
Surgical Specialties (United States)
2013
Magna Graecia University
2013
Northwest Medical Specialties
1999-2012
The goal of this study was to estimate the cumulative activity (131)I be administered patients with distant metastases from thyroid carcinoma.A total 444 were treated 1953-1994 for papillary and follicular carcinoma: 223 had lung only, 115 bone 82 both metastases, 24 at other sites. Treatment consisted administration 3.7 GBq (100 mCi) after withdrawal hormone treatment, every 3-9 months during first 2 yr then once a year until disappearance any metastatic uptake. Thyroxine treatment given...
Thyroid ultrasound (US) is a key examination for the management of thyroid nodules. US easily accessible, noninvasive, and cost-effective, mandatory step in workup The main disadvantage method that it operator dependent. assessment risk malignancy crucial patients with nodules, order to select those who should have fine needle aspiration (FNA) biopsy performed. Due pivotal role European Association convened panel international experts set up guidelines on stratification Based review...
Key MessageThis ESMO Clinical Practice Guideline provides updated state-of-the-art recommendations on management of thyroid cancer (diagnosis, treatment and follow-up), compiled by a multidisciplinary author panel accompanied level evidence grade recommendation, depending the strength supporting data magnitude benefit from particular interventions. This
IMPORTANCE Detection of asymptomatic thyroid nodules has increased.Consensus is lacking regarding the optimal follow-up cytologically proven benign lesions and sonographically nonsuspicious nodules.Current guidelines recommend serial ultrasound examinations reassessment cytology if significant growth observed.OBJECTIVE To determine frequency, magnitude, factors associated with changes in nodule size.DESIGN, SETTING, AND PARTICIPANTS Prospective, multicenter, observational study involving 992...
Abstract Context: BRAF mutations are common in papillary thyroid carcinomas (PTCs). By affecting the expression of genes critically related to development and differentiation cancer, they may influence prognosis these tumors. Objective: Our objective was characterize thyroid-specific associated with mutation PTCs. Design/Setting Patients: We examined key markers thyrocyte 56 PTCs (BRAF-mut) 37 wild-type (BRAF-wt). Eight samples normal tissue were analyzed as controls. Quantitative PCR used...
Routine serum calcitonin (CT) measurement in patients with thyroid nodules for diagnosis of medullary carcinoma (MTC) is controversial.The objective this study was to evaluate the diagnostic accuracy systematic CT non-multiple endocrine neoplasia type 2 nodular disease.This conducted at a national healthcare system hospital (outpatient and inpatient sectors).Consecutive disease (n = 5817) were studied.Serum levels measured under basal conditions, when values more than or equal 20 less 100...
The current use of life-long follow-up in patients with papillary thyroid cancer (PTC) is based largely on the study individuals diagnosed and treated latter half 20th century when recurrence rates were approximately 20% relapses detected up to 20-30 years after surgery. Since then, however, diagnosis, treatment, postoperative monitoring PTC have evolved significantly.The objective was identify times by which these occurred a more recent patient cohort.We retrospectively analyzed data for...
Abstract Context The prevalence of thyroid nodules in the general population is increasingly high, and at least half those biopsied prove to be benign. Sonographic risk-stratification systems are being proposed as “rule-out” tests that can identify do not require fine-needle aspiration (FNA) cytology. Objective To comparatively assess performances five internationally endorsed sonographic classification [those American Thyroid Association, Association Clinical Endocrinologists, College...
Ultrasonography is the best available tool for initial work-up of thyroid nodules. Substantial interobserver variability has been documented in recognition and reporting some lesion characteristics. A number classification systems have developed to estimate likelihood malignancy: several them endorsed by scientific societies, but their reproducibility yet be assessed. We evaluated AACE/ACE/AME, ACR, ATA, EU-TIRADS K-TIRADS concordance indication FNA biopsy. Two raters independently 1055...
With the widespread use of sensitive imaging techniques, which include neck visualization, a conspicuous number thyroid nodules emerge and demand attention. Most lesions are benign, asymptomatic, do not warrant treatment. In case cancer diagnosis, most small, intrathyroidal indolent neoplasms that can safely be managed conservatively. There is pronounced need for more cost-effective, risk-adapted approaches to management this highly prevalent condition, taking wishes patient into...
Serum thyroglobulin (Tg) assays are considered fundamental in postoperative surveillance of differentiated thyroid cancer (DTC) patients. However, the postsurgical profile Tg levels has never been specifically investigated patients who do not undergo radioiodine remnant ablation (RRA). Our objective was to explore evolution over time DTC treated with total or near-total thyroidectomy without RRA. We retrospectively analyzed 290 consecutively diagnosed cases low-risk (American Thyroid...
Small papillary thyroid carcinomas have contributed to the worldwide increased incidence of differentiated cancer observed over past decades. However, mortality rate has not changed same period time, raising questions about possibility that patients, especially those with small tumors, are overdiagnosed and overtreated. Molecular prognostic marker able discriminate aggressive cancers from an indolent course would be great relevance tailor therapeutic approach reduce overtreatment. Mutations...