A5000867450- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Thyroid Disorders and Treatments
- Neuroblastoma Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic and Hepatic Oncology Research
- BRCA gene mutations in cancer
- Pituitary Gland Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related Molecular Pathways
- Sperm and Testicular Function
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Clusterin in disease pathology
- Ovarian cancer diagnosis and treatment
- Head and Neck Cancer Studies
- S100 Proteins and Annexins
- Global Cancer Incidence and Screening
- Bone health and treatments
- Biomarkers in Disease Mechanisms
Azienda Sanitaria Unità Locale di Reggio Emilia
2017-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2024
Ospedale Santa Maria
2013-2023
ASL Roma
2023
Santa Maria Nuova Hospital
2014-2021
Arcispedale Sant'Anna
2003-2020
Ospedale Regina Apostolorum
2019
Azienda Ospedaliera S.Maria
1999-2017
Santa Maria Nuova Hospital
2010-2017
Endocrinology Research Center
2010
Standard therapeutic approaches for benign thyroid lesions that warrant intervention are surgery cold and either or radioiodine autonomously functioning nodules (AFTN). Image-guided thermal ablation (TA) procedures increasingly proposed as therapy options selected clinical conditions. Due to mounting scientific evidence widening availability, ETA considered it appropriate develop guidelines the use of TA in adult patients. well tolerated, but a dedicated training operators is required...
The follow-up of patients with differentiated thyroid carcinoma (DTC) is traditionally carried out (131)I whole body scan ((131)I WBS) and serum thyroglobulin (Tg) measurement. Neck ultrasonography (US) also used.We compared the roles Tg measurement (IRMA assay) after l-thyroxine (T4) withdrawal, WBS, US in diagnosis DTC neck recurrences. Diagnosis recurrences was based on fine-needle aspiration biopsy (FNAB) or histologic results. Four hundred ninety-four (120 males, 374 females; mean age,...
The management of thyroid papillary microcarcinoma (PMC) is controversial. Total thyroidectomy, lobectomy/isthmectomy, and even no treatment have been proposed. We investigated the clinical course prognostic factors for disease recurrence distant metastasis in 445 patients with PMC.Data from diagnosed PMC period 1978 to 2003 were reviewed analyzed. thyroidectomy was performed 404 loboisthmusectomy 41. Neck dissection took place 226 (49.7%), 166 only central compartment 60 both lateral...
A cohort of 1039 consecutive cases thyroid carcinoma treated at a single institution and followed for an average 11.9 years or until death included 102 encapsulated well-differentiated follicular-patterned tumors that had been diagnosed as because complete capsular invasion and/or papillary carcinoma-type nuclei. None these were among the 67 patients from who died result their carcinoma. The results this study critical review pertinent literature indicate with features are associated...
Transcriptional activating mutations in the promoter of telomerase reverse transcriptase (TERT) gene were reported at high frequency aggressive poorly differentiated and anaplastic thyroid cancers. By contrast, relevance these metastatic behavior well-differentiated cancer is still to be defined. The aim this work was investigate TERT a remarkable cohort papillary carcinoma that developed distant metastases (DM-PTCs) establish whether may predictive behavior.We analyzed group 43 highly...
Small papillary thyroid carcinomas have contributed to the worldwide increased incidence of differentiated cancer observed over past decades. However, mortality rate has not changed same period time, raising questions about possibility that patients, especially those with small tumors, are overdiagnosed and overtreated. Molecular prognostic marker able discriminate aggressive cancers from an indolent course would be great relevance tailor therapeutic approach reduce overtreatment. Mutations...
Background: Single-center trials demonstrated moderate-substantial level of interobserver agreement in the evaluation ultrasound (US) features thyroid nodules. Multicenter studies on US agreement, however, are scanty, and data intraobserver poor. Aim study was to assess inter- between different centers specialists. Methods: A blinded analysis 100 electronically recorded nodule images conducted three large-volume by seven radiologists endocrinologists. The repeated after randomization 4...
The identification of metastatic neck lymph nodes in patients awaiting surgery for differentiated thyroid tumor permits their excision during thyroidectomy. In order to detect cancer lymphatic metastasis before surgery, we measured thyroglobulin (Tg) the needle wash-out fine-needle aspiration biopsy (FNAB). Ultrasoundguided FNAB on enlarged was performed 23 (n = 33 nodes), 47 previously thyroidectomized 89 and 60 without disease 94 nodes). Immediately after biopsy, rinsed with 1 mL normal...
The expression of somatostatin receptors (SSTR) in thyroid cells may offer the possibility to identify metastatic lesions and select patients for peptide receptor radionuclide therapy (PRRT). We investigated (68)Ga-DOTATOC positron emission tomography/computed tomography (PET/CT) with progressive differentiated cancer (DTC) PRRT as well treatment response toxicity treated patients.We enrolled 41 radioiodine-negative DTC (24 women 17 men; mean age=54.3 years, median=59 range=19-78 years). In...
In this report, we compared endoscopic ultrasonography (EUS), multidetector CT (MDCT), and Ga-68 DOTATOC PET/CT in patients with neuroendocrine tumors (NETs). We report our experience use of these methods suspected to have duodenopancreatic primitive NET.Nineteen consecutive (mean age, 56; 21-80), who underwent both EUS between March 2007 November 2008 were retrospectively included the study (16 MDCT). Suspicion NET was confirmed by EUS-FNA and/or surgery. Operative characteristics PET, EUS,...
The relevance of the BRAF V600E mutation in papillary thyroid carcinoma (PTC) as a negative prognostic factor is subject intense debate. This has been associated with several clinicopathological features, but lack consistency among data does not support its usefulness marker tumor aggressiveness and poorer outcome. Due to genetic heterogeneity tumor, both occurrence allele percentage should be considered unravel this controversy.We aimed evaluate impact on metastatic process PTCs.The...
Background: Until recently, treatment of hypothyroidism has been accomplished using monotherapy synthetic L-thyroxine (L-T4) sodium tablets that should be taken 30-60 minutes before breakfast. Nowadays, a liquid preparation levothyroxine is available and can effectively replace without the need waiting having Evidence Quality life (QoL) improvement when shifting from former to latter preparation, however, still lacking. Objective: The study aimed assess changes in QoL hypothyroid patients...
Image-guided interventional ultrasound (US) techniques represent diagnostic and therapeutic tools for non-surgical management of thyroid nodular disease. We sought to investigate the attitude European Thyroid Association (ETA) members towards use minimally invasive (MIT) in diagnosis/therapy symptomatic goitre.ETA were invited participate an online survey investigating MIT benign malignant Of 865 members, 221 (25.5%) completed survey. The respondents from 40 countries; 139 (74.7%)...
This guideline (GL) is aimed at providing a reference for the management of non-functioning, benign thyroid nodules causing local symptoms in adults outside pregnancy.This GL has been developed following methods described Manual National Guideline System. For each question, panel appointed by Associazione Medici Endocrinology (AME) identified potentially relevant outcomes, which were then rated their impact on therapeutic choices. Only outcomes classified as "critical" and "important"...
Objective Thyroid nodule ultrasound characteristics are used as an indication for fine-needle aspiration cytology, usually the basis Imaging Reporting and Data System (TIRADS) score calculation. Few studies on interobserver variation available, all of which based analysis preselected still images often lack surgical confirmation. Methods After blinded online evaluation video recordings examinations 47 consecutive malignant 76 benign thyroid lesions, 7 experts from centers answered 17...
Fine needle aspiration (FNA) has long been recognized as an essential technique for the evaluation of thyroid nodules. Although specific cytological patterns have recognized, a wide variety reporting schemes FNA results adopted. This study reports our experience with five-category scheme developed in-house based on numeric score and applied to large series consecutive FNAs. It focuses mainly accuracy preoperative test in subset histologically distinct lesions.During 1998-2007 period, 18,359...