A5028427894- Radiopharmaceutical Chemistry and Applications
- Neuroendocrine Tumor Research Advances
- Curcumin's Biomedical Applications
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lanthanide and Transition Metal Complexes
- Metal complexes synthesis and properties
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Radioactive Decay and Measurement Techniques
- Radioactive element chemistry and processing
- Radiation Therapy and Dosimetry
- Nanoparticle-Based Drug Delivery
- Boron Compounds in Chemistry
- Neuroblastoma Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Radiation Detection and Scintillator Technologies
- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Nuclear Physics and Applications
- Medical Imaging and Pathology Studies
- Nanoplatforms for cancer theranostics
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2024
Azienda Sanitaria Unità Locale di Reggio Emilia
2018-2024
Azienda Sanitaria Locale di Asti
2015-2024
Tecnologie Avanzate (Italy)
2023
University of Trento
2020
Santa Maria Nuova Hospital
2007-2018
Ospedale Santa Maria
2013-2017
Santa Maria Nuova Hospital
2010-2017
Azienda Ospedaliera S.Maria
2012
University of Parma
2005
The expression of somatostatin receptors (SSTR) in thyroid cells may offer the possibility to identify metastatic lesions and select patients for peptide receptor radionuclide therapy (PRRT). We investigated (68)Ga-DOTATOC positron emission tomography/computed tomography (PET/CT) with progressive differentiated cancer (DTC) PRRT as well treatment response toxicity treated patients.We enrolled 41 radioiodine-negative DTC (24 women 17 men; mean age=54.3 years, median=59 range=19-78 years). In...
Curcumin (CUR) and curcuminoids complexes labeled with fluorine-18 or technetium-99m have recently shown their potential as diagnostic tools for Alzheimer's disease. Gallium-68 is a positron-emitting, generator-produced radionuclide, its properties can be exploited in situ medical facilities without cyclotron. Moreover, CUR showed higher uptake tumor cells compared to normal cells, suggesting applications this field. In spite of this, no studies using been performed direction, so far....
In this report, we compared endoscopic ultrasonography (EUS), multidetector CT (MDCT), and Ga-68 DOTATOC PET/CT in patients with neuroendocrine tumors (NETs). We report our experience use of these methods suspected to have duodenopancreatic primitive NET.Nineteen consecutive (mean age, 56; 21-80), who underwent both EUS between March 2007 November 2008 were retrospectively included the study (16 MDCT). Suspicion NET was confirmed by EUS-FNA and/or surgery. Operative characteristics PET, EUS,...
We report a simple method for the incorporation of Cu(I) or 64Cu(I) radionuclides in covellite nanocrystals (CuS NCs). After situ reduction Cu(II) 64Cu(II) ions by ascorbic acid, their PEG-coated CuS NCs takes place at room temperature. In all reaction steps, stability under physiological conditions was ensured. The copper could also take on bearing biotin molecules surface, with no detrimental effects specific binding affinity toward streptavidin after incorporation. At low loading Cu ions,...
The aim of this study was to assess the efficacy PRRT in patients with advanced neuroendocrine tumors (NETs). Patients and Methods. From January 2007 August 2011, we enrolled 65 (m/f 38/27; mean age years, range 33-83) NETs having enhanced SSTR expression, treated PRRT. expression assessed using (68)Ga-DOTATOC/DOTATATE PET/CT. Among all patients, 6 them were excluded from present analysis since they voluntarily interrupted treatment. Mean activity/cycle 2.6 GBq ((90)Y-DOTATOC/DOTATATE) or...
Theoretical calculations employing DFT at the B3LYP/6-311G++** level are used to investigate tautomeric equilibrium in curcumin derivatives. The solvent effect is evaluated using CPCM continuum solvation method. results compared with experimental data obtained from X-ray crystal structure of K2A23 and UV-vis data. KE tautomer more stable a vacuum solid state, while water DK reaches population 90%. In agreement spectroscopic data, theoretical predict slight prevalence form non-aqueous...
With a half-life of 7.45 days, silver-111 (βmax 1.04 MeV, Eγ 245.4 keV [Iγ 1.24%], 342.1 6.7%]) is promising candidate for targeted cancer therapy with β– emitters as well associated SPECT imaging. For its clinical use, the development suitable ligands that form sufficiently stable Ag+-complexes in vivo required. In this work, following sulfur-containing derivatives tetraazacyclododecane (cyclen) have been considered potential chelators silver-111:...
The clinical success of [
The interest in mercury radioisotopes,
The Cu 2+/+ complexes formed by sulfur-containing polyazamacrocycles were studied in aqueous solution using potentiometry, UV-Vis, NMR, EPR, and cyclic voltammetry.
Copper radioisotopes are generally employed for cancer imaging and therapy when firmly coordinated via a chelating agent coupled to tumor-seeking vector. However, the biologically triggered Cu2+-Cu+ redox switching may constrain in vivo integrity of resulting complex, leading demetallation processes. This unsought pathway is expected be hindered by chelators bearing N, O, S donors which appropriately complements borderline-hard soft nature Cu2+ Cu+. In this work, labelling performances...
Radio Pharmaceutical Therapy (RPT) comes forth as a promising technique to treat wide range of tumors while ensuring low collateral damage nearby healthy tissues. This kind cancer therapy exploits the radiation following decay specific radionuclide deliver lethal dose tumor In framework ISOLPHARM project INFN, 111Ag was recently proposed core therapeutic radiopharmaceutical. this paper, production via neutron activation 110Pd-enriched samples inside TRIGA Mark II nuclear research reactor is...
Brain tumors characterization by molecular imaging that allows the depiction of brain lesions metabolic pattern is crucial. Our study aimed to: 1) to evaluate diagnostic performances [18F]fluoroethylcholine positron emission tomography/computed tomography ([18F]FECH PET/CT), and 2) correlate PET derived parameters [18F]FECH survival in tumors.From 2009 2012, we enrolled 30 patients who underwent PET/CT. Final diagnosis was established clinical radiological follow-up.Final consistent with...
In spite of the hazard due to radiation exposure, preparation 90 Y- and 177 Lu-labelled radiopharmaceuticals is still mainly performed using manual procedures. present study performance a commercial automatic synthesizer based on disposable cassettes for labelling Lu- Y-DOTA-conjugated biomolecules (namely, DOTATOC PSMA-617) was evaluated compared semiautomated approach. The dose exposure operators as well. More than 300 clinical preparations both have been three different methods. mean...
The cholecystokinin-2 receptor (CCK-2R) is overexpressed in several human cancers but displays limited expression normal tissues. For this reason, it a suitable target for developing specific radiotracers. In study, nastorazepide-based ligand functionalized with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator (IP-001) was synthesized and labelled indium-111. radiolabeling process yielded >95% molar activity of 10 MBq/nmol radiochemical purity >98%. Stability...
Curcumin is known for its therapeutic properties; among these, antioxidant, anti-inflammatory and anti-cancer ones stand out. Besides, curcumin metal complexes have shown widespread application in medicine can be exploited as lead structures developing metal-based drugs. Unfortunately, poorly bioavailable, mainly due to instability physiological conditions; this weakness tightly connected the presence of β-diketo moiety undergoing tautomeric equilibrium. Stability metal-chelating ability...
Curcumin derivatives labelled with fluorine-18 or technetium-99m have recently shown their potential as diagnostic tools for Alzheimer’s disease. Nevertheless, no study by exploiting the labelling gallium-68 has been performed so far, in spite of its suitable properties (positron emitter, generator produced radionuclide). Herein, an evaluation affinity synthetic β-amyloid fibrils and amyloid plaques three nat/68Ga-labelled curcumin analogues, namely (CUR), bis-dehydroxy-curcumin (bDHC)...