A5006279666- Epigenetics and DNA Methylation
- Metastasis and carcinoma case studies
- Peptidase Inhibition and Analysis
- Thyroid Cancer Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Acute Myeloid Leukemia Research
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- Ubiquitin and proteasome pathways
- Neuroblastoma Research and Treatments
- Cell death mechanisms and regulation
- Immune cells in cancer
- Infectious Diseases and Mycology
- Antioxidant Activity and Oxidative Stress
- Medical Imaging and Pathology Studies
Azienda Sanitaria Unità Locale di Reggio Emilia
2017-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Ospedale Santa Maria
2024
University of Modena and Reggio Emilia
2010-2015
Thomas Jefferson University
2012
Sidney Kimmel Cancer Center
2012
National Agency for New Technologies, Energy and Sustainable Economic Development
2012
Ferrari (Italy)
2010
The process of epithelial-mesenchymal transition (EMT) which is required for cancer cell invasion regulated by a family E-box-binding transcription repressors, include Snail (SNAIL1) and Slug (SNAI2). appears to repress the expression EMT marker E-cadherin epigenetic mechanisms dependent on interaction its N-terminal SNAG domain with chromatin-modifying proteins including lysine-specific demethylase 1 (LSD1/KDM1A). We assessed whether blocking Snail/Slug-LSD1 treatment Parnate, an enzymatic...
Most triple-negative breast cancers (TNBCs) exhibit gene expression patterns associated with epithelial-to-mesenchymal transition (EMT), a feature that correlates propensity for metastatic spread. Overexpression of the EMT regulator Slug is detected in basal and mesenchymal-type TNBCs reduced E-cadherin aggressive disease. The effects depend, part, on interaction its N-terminal SNAG repressor domain chromatin-modifying protein lysine demethylase 1 (LSD1); thus, we investigated whether...
Aberrant reactivation of embryonic pathways is a common feature cancer. RUNX2 transcription factor crucial during embryogenesis that aberrantly reactivated in many tumors, including thyroid and breast cancer, where it promotes aggressiveness metastatic spreading. Currently, the mechanisms driving expression cancer are still largely unknown. Here we showed requires cooperation three distantly located enhancers (ENHs) brought together by chromatin three-dimensional looping. We BRD4 controls...
Background: Papillary thyroid cancers (PTCs) are common, usually indolent malignancies. Still, a small but significant percentage of patients have aggressive tumors and develop distant metastases leading to death. Currently, it is not possible discriminate lesions due lack prognostic markers. Long noncoding RNAs (lncRNAs), which selectively expressed in context-dependent manner, expected represent new landscape search for molecular discriminants. Transforming growth factor β (TGFβ)...
B cells have emerged as central players in the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC). However, although there is clear evidence for their involvement immunity, scanty data exist on characterization phenotypes, bioenergetic profiles and possible interactions with T context NSCLC. In this study, using polychromatic flow cytometry, mass spatial transcriptomics we explored intricate landscape bioenergetics, interaction Our analysis revealed that TME contains diverse...
Pulmonary sarcomatoid carcinoma (PSC) is a rare and aggressive form of NSCLC. Rarity poor characterization have limited the development PSC-tailored treatment protocols, leaving patients with inadequate therapeutic options. In this study, we investigated gene expression profile PSCs, aim to characterize molecular mechanisms responsible for their evolution identify new drugs treatment.A training set 17 biphasic PSCs was selected tested large panel 770 genes related cancer progression using...
// Greta Gandolfi 1 , Moira Ragazzi 2 Dario de Biase 3 Michela Visani 4 Eleonora Zanetti Federica Torricelli Valentina Sancisi Mila Gugnoni Gloria Manzotti Luca Braglia 5 Silvio Cavuto Domenico Franco Merlo Giovanni Tallini Andrea Frasoldati 6 Simonetta Piana and Alessia Ciarrocchi Laboratory of Translational Research, Azienda Unità Sanitaria Locale di Reggio Emilia - IRCCS, 42123, Italy Pathology Unit, Department Oncology, Pharmacology Biotechnology (FaBiT), University Bologna, 40139...
Anaplastic Thyroid Cancer (ATC) is an undifferentiated and aggressive tumor that often originates from well-Differentiated Carcinoma (DTC) through a trans-differentiation process. Epithelial-to-Mesenchymal Transition (EMT) recognized as one of the major players this OVOL2 transcription factor (TF) promotes epithelial differentiation restrains EMT during embryonic development. loss in some types cancers linked to aggressiveness poor prognosis. Here, we aim clarify unexplored role ATC.Gene...
Multiple myeloma (MM) is a dreadful disease, marked by the uncontrolled proliferation of clonal plasma cells (PCs) within bone marrow (BM). MM characterized highly heterogeneous clinical and molecular background, supported severe genomic alterations. Important deregulation long non-coding RNAs (lncRNAs) expression has been reported in patients, influencing progression therapy resistance. NEAT1 lncRNA essential for nuclear paraspeckles involved gene regulation. We showed that supports making...
The transcription factor C/EBPα is required for granulocytic differentiation of normal myeloid progenitors and frequently inactivated in acute leukemia (AML) cells. Ectopic expression AML cells suppresses proliferation induces suggesting that restoring expression/activity could be therapeutically useful. Unfortunately, current approaches gene or protein delivery leukemic are unsatisfactory. However, "drug repurposing" becoming a very attractive strategy to identify potential new uses...
RUNX2 is a Runt-related transcription factor required during embryogenesis for skeletal development and morphogenesis of other organs including thyroid breast gland. Consistent evidence indicates that expression aberrantly reactivated in cancer supports tumor progression. The mechanisms leading to has only recently began emerge. Previously, we showed suppressing the activity epigenetic regulators HDACs significantly represses highlighting role these enzymes reactivation cancer. However,...
Abstract Deregulation of chromatin modifiers, including DNA helicases, is emerging as one the mechanisms underlying transformation anaplastic lymphoma kinase negative (ALK − ) large cell (ALCL). We recently identified DNA-helicase HELLS central for proficient ALK ALCL proliferation and progression. Here we assessed in detail its function by performing RNA-sequencing profiling coupled with bioinformatic prediction to identify targets transcriptional cooperators. demonstrated that HELLS,...
Background: Endometrial cancer (EC) is the most common gynecologic tumor and world’s fourth in women. Most patients respond to first-line treatments have a low risk of recurrence, but refractory patients, those with metastatic at diagnosis, remain no treatment options. Drug repurposing aims discover new clinical indications for existing drugs known safety profiles. It provides ready-to-use therapeutic options highly aggressive tumors which standard protocols are ineffective, such as...
Summary Recent evidence indicates that melanoma comprises distinct types of tumors and suggests specific morphological features may help predict its clinical behavior. Using a SNP ‐array approach, we quantified chromosomal copy number alterations ( CNA ) across the whole genome in 41 primary melanomas found high degree heterogeneity their genomic asset. Association analysis correlating relative length with clinical, morphological, dermoscopic attributes revealed aggressiveness were strongly...
The c-Myb gene encodes the p75(c-Myb) isoform and less-abundant proteins generated by alternatively spliced transcripts. Among these, best known is p(c-Mybex9b), which contains 121 additional amino acids between exon 9 10, in a domain involved protein-protein interactions negative regulation. In hematopoietic cells, expression of p(c-Mybex9b) accounts for 10-15% total c-Myb; these levels may be biologically relevant because modest changes affects proliferation survival leukemic cells lineage...
The transcription factor C/EBPα is more potent than C/EBPβ in inducing granulocitic differentiation and inhibiting BCR/ABL-expressing cells. We took a “domain swapping” approach to assess biological effects, modulation of gene expression, binding C/EBPα-regulated promoters by wild-type chimeric C/EBPα/C/EBPβ proteins. Wild-type N-C/EBPα+ C/EBPβ-DBD induced the granulocyte-colony stimulating receptor (G-CSFR) gene, promoted differentiation, suppressed proliferation K562 cells vigorously;...