A5010550942- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune cells in cancer
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Phagocytosis and Immune Regulation
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Ferroptosis and cancer prognosis
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Cancer Diagnosis and Treatment
University of Modena and Reggio Emilia
2019-2025
McLean Hospital
2023
QIMR Berghofer Medical Research Institute
2023
Ollscoil na Gaillimhe – University of Galway
2023
Tumors develop within complex cell-to-cell interactions, with accessory cells playing a relevant role starting in the early phases of cancer progression. This event occurs three-dimensional (3D) environment, which to date, has been difficult reproduce vitro due its complexity. While bi-dimensional cultures have generated substantial data, there is progressive awareness that 3D culture strategies may rapidly increase understanding tumor development and be used anti-cancer compound screening...
Background: Lung cancer stem cells (CSCs) share many characteristics with normal cells, such as self-renewal and multipotentiality. High expression of aldehyde dehydrogenase (ALDH) has been detected in tumors, particularly the CSC compartment, it plays an important role tumor proliferation, metastasis, drug resistance. CD44 is commonly used a cell surface marker stem-like epithelial tumors. The aim this study was to isolate analyze from surgically removed specimens compare lung...
Several studies demonstrated that aldehyde dehydrogenase (ALDH) and CD44 are the most considered cancer stem cells (CSC) markers. However, a comparison between ALDH high CD44+ have been previously described with no significant correlation. Indeed, aim of present research is to identify superficial marker able match population in freshly isolated human lung cells.This cross-sectional study analyzed expression ALDHhigh/low positivity for epithelium cell adhesion molecule (EPCAM) antigens...
B cells have emerged as central players in the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC). However, although there is clear evidence for their involvement immunity, scanty data exist on characterization phenotypes, bioenergetic profiles and possible interactions with T context NSCLC. In this study, using polychromatic flow cytometry, mass spatial transcriptomics we explored intricate landscape bioenergetics, interaction Our analysis revealed that TME contains diverse...
Abstract Purpose Lung cancer relapse may be associated with the presence of a small population stem cells (CSCs) unlimited proliferative potential. Our study assessed relationship between CSCs and rate in patients harboring adenocarcinoma (ADL) squamous cell carcinoma lung (SCCL). Experimental design This is an observational prospective cohort (NCT04634630) assessing influence CSC frequency on after major resection 35 early (I-II) (n = 21) locally advanced (IIIA) 14) ADL SCCL. There was...
Lung cancer stem cells (LCSCs) are endowed with high aldehyde dehydrogenase (ALDH) expression and play roles in tumor proliferation, metastasis, drug resistance. Their elusive nature may allow them to escape the immune response by tumor-infiltrating lymphocytes (TILs), which can positively affect outcome non-small cell lung (NSCLC) patients. Despite independent investigations on both LCSCs TILs, relationship between two has been very marginally considered. We analyzed whether these types be...
Introduction Lung cancer is one of the most common cancers in world, causing over 1.7 million deaths 2018. Thus far, no effective treatments against lung for advanced stages have been found. For early stages, although surgery considered gold standard treatment, 30–55% patients develop recurrence within first 5 years surgery. Our aim to assess whether stem cells (CSC) display overexpression a pool genes that were previously identified adenocarcinoma with and locally non-small cell (NSCLC)....
The proapoptotic protein tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is physiologically expressed by immune cells and performs regulatory functions in infections, autoimmune diseases cancer, where it acts as a suppressor. Adipose-derived mesenchymal stromal (AD-MSCs) also may play immunomodulatory roles both primary acquired responses. We have previously demonstrated the efficacy of an anticancer gene therapy based on AD-MSC engineered to secrete soluble TRAIL variant...
Introduction Idiopathic pulmonary fibrosis (IPF) severely affects the lung leading to aberrant deposition of extracellular matrix and parenchymal stiffness with progressive functional derangement. The limited availability fresh tissues represents one major limitations study molecular profiling IPF tissue. primary aim this was explore proteomic yield archived formalin-fixed paraffin-embedded (FFPE) specimens tissues. Methods We further determined protein expression according respiratory...
// Beatrice Aramini 1 , Federico Banchelli 3 Stefania Bettelli 4 Samantha Manfredini Roberto D'Amico Valentina Masciale Massimo Pinelli 5 Margherita Moretti Alessandro Stefani Federica Bertolini 2 Dominici Uliano Morandi and Antonino Maiorana Division of Thoracic Surgery, Department Medical Surgical Sciences, University Modena Reggio Emilia, Modena, Italy Oncology, Center Statistics, Institute Pathology, Plastic Correspondence to: Aramini, email: beatrice.aramini@unimore.it Keywords: somatic...