A5081648394- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Prostate Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Prostate Cancer Treatment and Research
- Colorectal and Anal Carcinomas
- Urologic and reproductive health conditions
- Melanoma and MAPK Pathways
- Cancer Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Cancer Cells and Metastasis
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Inflammatory Bowel Disease
- Cancer, Lipids, and Metabolism
- Lung Cancer Treatments and Mutations
- Cutaneous Melanoma Detection and Management
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
University of Modena and Reggio Emilia
2016-2025
Azienda Ospedaliero-Universitaria di Modena
2014-2023
Federico II University Hospital
2023
Azienda Unita' Sanitaria Locale Di Modena
2019-2020
Creative Research Enterprises (United States)
2017-2020
Universidade Federal de São Paulo
2020
Jackson and Tull (United States)
2020
Marche Polytechnic University
2020
Azienda Sanitaria Unità Locale di Reggio Emilia
2017
Istituto Ortopedico Gaetano Pini
2017
Abstract Background Immunotherapy with immune checkpoint inhibitors (ICIs) is highly effective in microsatellite instability–high (MSI-H) metastatic colorectal cancer (mCRC); however, specific predictive biomarkers are lacking. Patients and Methods Data samples from 85 patients MSI-H mCRC treated ICIs were gathered. Tumor infiltrating lymphocytes (TILs) tumor mutational burden (TMB) analyzed an exploratory cohort of “super” responders “clearly” refractory patients; TILs then evaluated the...
Abstract Purpose: BRAF mutations are grouped in activating RAS-independent signaling as monomers (class 1–V600E) or dimers 2–codons 597/601), and RAS-dependent with impaired kinase activity 3–codons 594/596). Although clinical, pathologic, molecular features of V600EBRAF-mutated metastatic colorectal cancer (mCRC) well known, limited data available from the two other classes. Experimental Design: Data 117 patients (92 class 1, 12 2, 13 3)-mutated mCRC were collected. A total 540 wt mCRCs...
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options and poor prognosis. The critical role of epigenetic alterations such as changes in DNA methylation, histones modifications, chromatin remodeling, pancreatic tumors progression becoming increasingly recognized. Moreover, PDAC these aberrant mechanisms can also limit therapy efficacy. This study aimed to investigate the expression prognostic significance key complex...
The nephron, the basic structural and functional unit of vertebrate kidney, is organized into discrete segments, which are composed distinct renal epithelial cell types. Each type carries out highly specific physiological functions to regulate fluid balance, osmolarity, metabolic waste excretion. To date, genetic basis regionalization nephron has remained largely unknown. Here we show that Irx3 , a member Iroquois (Irx) gene family, acts as master regulator intermediate tubule fate....
Abstract Background The pronephros, the simplest form of a vertebrate excretory organ, has recently become an important model kidney organogenesis. Here, we elucidated nephron organization Xenopus pronephros and determined similarities in segmentation with metanephros, adult mammals. Results We performed large-scale gene expression mapping terminal differentiation markers to identify patterns that define distinct domains pronephric kidney. analyzed over 240 genes, which included members...
To report the first application of ex vivo fluorescence confocal microscopy (FCM) - a novel optical technology that is capable providing fast microscopic imaging unfixed tissue specimens- in urological field assessing its diagnostic accuracy for non neoplastic and cancerous prostate (prostatic adenocarcinoma) compared to 'gold standard' histopathological diagnoses.In all, 89 specimens from 13 patients with clinically localised cancer were enrolled into study. All underwent robot-assisted...
Objective To demonstrate the association between magnetic resonance imaging ( MRI ) estimated lesion volume LV ), prostate cancer detection and tumour clinical significance, evaluating this variable alone matched with Prostate Imaging Reporting Data System version 2 PI ‐ RADS v2) score. Patients methods We retrospectively analysed 157 consecutive patients, at least one prior negative systematic prostatic biopsy, who underwent transperineal /ultrasonography fusion‐targeted biopsy January 2014...
An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's [CrD]. We explored clinico-pathological, molecular, prognostic features CD-associated SBC [CD-SBC] CrD-associated [CrD-SBC] comparison with sporadic [spo-SBC].A total 76 patients undergoing surgical resection for non-familial [26 CD-SBC, 25 CrD-SBC, spo-SBC] were retrospectively enrolled to investigate patients' survival histological molecular including microsatellite instability [MSI]...
Several studies have suggested that the presence of occult nodal metastases (micrometastases) is related to adverse clinical course in stage I colorectal carcinoma. Herein we analyzed correlation between micrometastases and lymphovascular invasion (LVI) or lymphatic vessel density (LVD) a series carcinomas; cohort included cases characterized not by disease progression during follow-up. In these cases, LVI LVD were evidenced through immunohistochemical detection specific marker for vessels,...
Aberrant DNA methylation has been widely investigated in sporadic colorectal carcinomas (CRCs), and extensive work performed to characterize different profiles of CRC. Less information is available about the role epigenetics hereditary CRC possible clinical use epigenetic biomarkers CRC, regardless etiopathogenesis. Long interspersed nucleotide element 1 (LINE-1) hypomethylation gene-specific hypermethylation 38 promoters were analyzed multicenter series 220 CRCs including 71 Lynch (Lynch...
Bone and muscle have been recognized as endocrine organs since they produce secrete “hormone-like factors” that can mutually influence each other tissues, giving rise to a “bone–muscle crosstalk”. In our study, we made use of myogenic (C2C12 cells) osteogenic (2T3 cell lines investigate the effects cell-produced factors on maturation process osteoblasts. We found medium has inhibitory bone differentiation identified sclerostin one myokines produced by cells. Sclerostin is secreted...
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease, characterized by an intense desmoplastic reaction that compresses blood vessels and limits nutrient supplies. PDAC aggressiveness largely relies on its extraordinary capability to thrive progress in challenging tumor microenvironment. Dysregulation of the onco-suppressor miR-15a has been extensively documented PDAC. Here, we identified transcription factor Fos-related antigen-2 (Fra-2) as target mediating adaptive mechanism...