A5019327502- Inflammatory Bowel Disease
- Microscopic Colitis
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Hepatitis B Virus Studies
- Diverticular Disease and Complications
- Gastrointestinal motility and disorders
- Colorectal and Anal Carcinomas
- Diverse academic and cultural studies
- Hepatitis C virus research
- COVID-19 and healthcare impacts
- Gut microbiota and health
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2017-2025
University of Milan
2016-2025
Ospedale Maggiore
2005-2025
Istituti di Ricovero e Cura a Carattere Scientifico
1998-2024
Humanitas University
2023
Presidio Ospedaliero
2023
IRCCS Policlinico San Donato
2013-2022
Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo
2021
Ospedale San Paolo
2021
Organizzazione Sociopsichiatrica Cantonale
2020
Crohn's disease (CD) is a chronic progressive destructive disease. Currently available instruments measure activity at specific point in time. An instrument to cumulative structural damage the bowel, which may predict long-term disability, needed. The aim of this article outline methods develop an that can bowel damage. project being conducted by International Program New Indexes (IPNIC) group. This instrument, called Disease Digestive Damage Score (the Lémann score), should take into...
IL-33 is a novel member of the IL-1 family and ligand for receptor-related protein, ST2. Recent evidence suggests that IL-33/ST2 axis plays critical role in several autoimmune inflammatory disorders; however, its bowel disease (IBD) has not been clearly defined. We characterized ST2 expression modulation after conventional anti-TNF therapy Crohn's ulcerative colitis (UC) patients investigated SAMP1/YitFc (SAMP) mice, mixed Th1/Th2 model IBD. Our results showed specific increase mucosal...
<h3>Objective</h3> Through genome-wide association scans and meta-analyses thereof, over 70 genetic loci (Crohn9s disease (CD) single nucleotide polymorphisms (SNPs)) are significantly associated with CD. We aimed to investigate the influence of CD-SNPs basic patient characteristics on CD clinical course, develop statistical models predict course. <h3>Design</h3> This retrospective study included 1528 patients more than 10 years follow-up from eight European referral hospitals. outcomes...
To assess the long-term outcome in hepatitis B surface antigen (HBsAg) carriers who have normal liver function tests, focusing on survival and development of severe disease hepatocellular carcinoma.Cohort study with a mean follow-up 130 months.Liver clinic referral center.Ninety-two HBsAg-positive blood donors tests.Histologic evaluation specimens at baseline; clinical, biochemical, serologic follow-up; repeat biopsy if clinically indicated or after 10 years follow-up.At baseline, 69...
In a subset of patients attending liver units, chronic increase in serum transaminases may remain undetermined cause despite thorough investigations. On the other hand, elevated levels have been reported about 40% adult celiac patients. To evaluate prevalence subclinical disease with unexplained hypertransaminasemia comparison that general population (0.5%), 140 consecutive increases unknown were tested for antigliadin and antiendomysium IgA antibodies. All positive antibody tests offered...
Objectives: To evaluate the role of immunological tests for monitoring lupus nephritis (LN) activity. Methods: C3, C4, anti-dsDNA and anti-C1q antibodies were prospectively performed over 6 years in 228 patients with LN. Results: In membranous LN only differentiated proteinuric flares from quiescent disease (p = 0.02). However, this group 46% occurred a normal value versus 20% proliferative antiphospholipid (APL), 33% levels 14.5% that APL-negative LN, showed slightly better sensitivity...
<h3>Objective</h3> Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating efficacy and safety mesalazine patients with <h3>Design</h3> We conducted phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial Rome III confirmed Patients were randomly assigned to either mesalazine, 800 mg, or placebo, three times daily for 12 weeks, followed additional weeks. The primary endpoint was satisfactory relief...
Evidence suggests a role of intestinal microbiota-host interactions in the pathophysiology and symptoms irritable bowel syndrome (IBS).
Gastrointestinal infections represent a risk factor for functional gastrointestinal and somatoform extraintestinal disorders. We investigated the prevalence relative (RR) of symptoms 5 months after SARS-CoV-2 infection compared with control cohort.
A cure for Crohn's disease (CD), a chronic inflammatory of the gastrointestinal tract unknown etiology, is not available, so patients require lifelong management to keep inflammation under control. The therapeutic armamentarium has expanded with approval several biological drugs, including infliximab, adalimumab, vedolizumab and ustekinumab - monoclonal antibodies that target different pathways darvadstrocel, suspension human allogeneic, adipose-derived, mesenchymal stromal cells treatment...
Individuals with inflammatory bowel disease (IBD) are at increased risk for thrombosis and vitamin deficiencies. Low plasma levels of B(6) an independent factor may cause hyperhomocysteinemia, another recognized thrombosis. The aim this study was to evaluate in IBD patients.We studied 61 patients: 32 Crohn's 29 ulcerative colitis. For each patient, three sex- age-matched healthy control subjects were studied.Median significantly lower patients (22.0 pmol/L, range 3.6-231.0) than controls...
Objective To evaluate the prevalence of microalbuminuria (albumin excretion rate, AER) in a wide hypertensive population, and to any relationship with cardiovascular damage renal dysfunction Design A transversal study Subjects methods In 383 hospitalized Caucasian essential hypertensives (198 men, 185 women) mean age 44 ±0.5 years clinic blood pressure 170.3 ±0.95/ 103.4 ±0.47 mmHg, metabolic parameters, serum creatinine level (Cs), clearance rate (CCR), 24 AER plasma renin activity (PRA)...
We detected in human colon extracts a 40 kDa protein(s) that specifically reacts with tissue-bound IgG obtained from the of patients ulcerative colitis or CCA-IgG. Using hybridoma technology, we developed monoclonal antibodies to this protein. The specific immunoreactivity one (7E12H12, IgM isotype) against protein was demonstrated both by ELISA and immunotransblot. Competitive binding experiments showed CCA-IgG inhibits 7E12H12 protein, suggesting recognition common epitope(s) on antibody...
Recent evidence suggests that the IL-33/IL1RL1 axis plays a critical role in several autoimmune and inflammatory disorders; however, its mechanistic bowel disease (IBD) has not been clearly defined. We investigated contribution of IL-33 IL1RL1 polymorphisms to IBD risk, possible correlations with phenotype an Italian cohort adult pediatric patients.We evaluated association six SNPs genes, 805 Crohn's (CD), 816 ulcerative colitis (UC), 752 controls, using Taqman. mRNA expression was also...