A5103093229- Eosinophilic Esophagitis
- IL-33, ST2, and ILC Pathways
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Immune Cell Function and Interaction
- Inflammatory Bowel Disease
- Dysphagia Assessment and Management
- Liver Disease and Transplantation
- Celiac Disease Research and Management
- Gastrointestinal disorders and treatments
- Organ Transplantation Techniques and Outcomes
- Metastasis and carcinoma case studies
- Microscopic Colitis
- Anorectal Disease Treatments and Outcomes
- Cytokine Signaling Pathways and Interactions
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Diverticular Disease and Complications
- Barrier Structure and Function Studies
- Liver physiology and pathology
- Spine and Intervertebral Disc Pathology
Maria Cecilia Hospital
2007-2022
University of Bologna
2006-2019
Medica (Italy)
2018
Case Western Reserve University
2010-2016
University School
2012-2016
Menlo School
2014
IRCCS Policlinico San Donato
2011
University of Milan
2011
Policlinico S.Orsola-Malpighi
2007
IL-33 is a novel member of the IL-1 family and ligand for receptor-related protein, ST2. Recent evidence suggests that IL-33/ST2 axis plays critical role in several autoimmune inflammatory disorders; however, its bowel disease (IBD) has not been clearly defined. We characterized ST2 expression modulation after conventional anti-TNF therapy Crohn's ulcerative colitis (UC) patients investigated SAMP1/YitFc (SAMP) mice, mixed Th1/Th2 model IBD. Our results showed specific increase mucosal...
Background We previously showed that the probiotic mixture, VSL#3, prevents onset of ileitis in SAMP/YitFc (SAMP) mice, and this effect was associated with stimulation epithelial-derived TNF. The aim study to determine mechanism(s) VSL#3-mediated protection on epithelial barrier function further investigate "paradoxical" effects TNF preventing SAMP ileitis. Methods Permeability evaluated mice prior inflammation during established disease by measuring transepithelial electrical resistance...
Pharyngo-oesophageal perforation is a rare, life-threatening complication of anterior cervical discectomy and fusion surgery; its management remains poorly defined. We reviewed our experience to understand the treatment this dreadful complication.Data regarding demographics, clinical course, diagnosis, outcomes 15 cases pharyngo-oesophageal perforations in 14 patients were collected during period from 2003 2016.Pharyngo-oesophageal occurred at median 32 days (range 1 day-102 months) after...
Type III–IV hiatal hernia (HH) is associated with a true short oesophagus in more than 50% of cases; dedicated treatment this condition might be appropriate to reduce the recurrence rate after surgery. A case series patients receiving surgery for was examined oesophagus, and results were analysed. From 1980 1994, 60 underwent an open surgical approach, position oesophago-gastric junction visually localized; from 1995 2013, 48 minimally invasive objectively localized using...
Controversy exists regarding surgery for true short oesophagus (TSOE). We compared the results of thoracoscopic Collis gastroplasty–laparoscopic Nissen procedure treatment TSOE with standard laparoscopic fundoplication. Between 1995 and 2013, Collis–Nissen was performed in 65 patients who underwent minimally invasive when length abdominal oesophagus, measured intraoperatively after maximal oesophageal mediastinal mobilization, ≤1.5 cm. The were frequency-matched according to age, sex period...
Objective: To explore the true short esophagus (TSE) frequency and long-term results of patients undergoing gastroesophageal reflux disease (GERD) or hiatus hernia (HH) surgery. Background: The existence treatment TSE during GERD/HH surgery is controversial. Satisfactory have been achieved with without surgical techniques dedicated to TSE. Methods: In 311 consecutive minimally invasive for GERD/HH, distance between endoscopically-localized junction (GEJ) apex diaphragmatic after maximal...
The risk factors for oesophageal achalasia, a precancerous condition that can lead to epidermoid carcinoma, are unknown. aim of this study was determine these factors.Beginning in 1973, patients presenting with achalasia from 1955 2016 periodically underwent clinical assessment, the barium swallow test (the diameter and residual column were measured) endoscopy according prospective protocol. We included minimum follow-up duration 12 months.Of 681 cases, 583 considered. median time 147.13...
In Siewert type I/II oesophageal adenocarcinoma, the sensitivity and specificity of computed tomography (CT), positron emission (PET)-CT endoscopic ultrasound (EUS) for assessment N descriptor in defined groups lymph nodes were investigated.CT, PET/CT, EUS images pathological data 101 adenocarcinomas submitted to primary resection compared. The identified as (a) right paratracheal/subcarinal/pulmonary ligament; (b) paraoesophageal; (c) paracardial; (d) left gastric artery, lesser curvature;...
Abstract IL-33 is a pleiotropic cytokine known to possess dichotomous roles during gut health and disease. We previously described that promotes epithelial restitution/repair in otherwise healthy (C57BL/6) mice have been challenged with dextran sodium sulphate (DSS) induce acute colitis, the end result of efficient resolution inflammation. However, SAMP1/YitFc (SAMP) spontaneously develop Crohn’s disease (CD)-like ileitis, elevated levels persist as progresses, perpetuating chronic...
BackgroundFibrosis is a prominent feature of the 2 primary forms IBD, Crohn's disease (CD) and ulcerative colitis (UC), characterized by chronic relapsing inflammatory condition GI tract. Interleukin (IL)-33, one newest members IL-1 family cytokines, involved in several different autoimmune diseases, including IBD. The goal this study to determine role commensal flora inducing IL-33 Th2 immune response, its impact on intestinal fibrosis an experimental model i.e., SAMP1/YitFc (SAMP) mouse strain.