A5056897300- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Metabolism and Genetic Disorders
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Diet and metabolism studies
- Autoimmune and Inflammatory Disorders
- Iron Metabolism and Disorders
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Folate and B Vitamins Research
- Blood Coagulation and Thrombosis Mechanisms
- Mitochondrial Function and Pathology
- Cancer Immunotherapy and Biomarkers
- Pregnancy and Medication Impact
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal motility and disorders
- Diverticular Disease and Complications
- Chronic Lymphocytic Leukemia Research
- Digestive system and related health
- Gastric Cancer Management and Outcomes
- Systemic Lupus Erythematosus Research
- Thyroid and Parathyroid Surgery
University of Catania
2015-2025
Sapienza University of Rome
2024
IRCCS Policlinico San Donato
2010-2022
Ospedale Maggiore
2005-2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
Policlinico Universitario di Catania
2021-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2022
University of Rome Tor Vergata
2017
University of Milan
2003-2016
Genetic Analysis (Norway)
2016
IL-33 is a novel member of the IL-1 family and ligand for receptor-related protein, ST2. Recent evidence suggests that IL-33/ST2 axis plays critical role in several autoimmune inflammatory disorders; however, its bowel disease (IBD) has not been clearly defined. We characterized ST2 expression modulation after conventional anti-TNF therapy Crohn's ulcerative colitis (UC) patients investigated SAMP1/YitFc (SAMP) mice, mixed Th1/Th2 model IBD. Our results showed specific increase mucosal...
Individuals with inflammatory bowel disease (IBD) are at increased risk for thrombosis and vitamin deficiencies. Low plasma levels of B(6) an independent factor may cause hyperhomocysteinemia, another recognized thrombosis. The aim this study was to evaluate in IBD patients.We studied 61 patients: 32 Crohn's 29 ulcerative colitis. For each patient, three sex- age-matched healthy control subjects were studied.Median significantly lower patients (22.0 pmol/L, range 3.6-231.0) than controls...
Abstract Background In a 6-year, multicenter, prospective nested case–control study, we aimed to evaluate risk factors for incident cancer in inflammatory bowel disease (IBD), when considering clinical characteristics of IBD and immunomodulator use. The secondary end point was provide characterization types. Methods All cases occurring patients from December 2011–2017 were prospectively recorded 16 Italian Group the Study Inflammatory Bowel Disease units. Each with new diagnosis matched 2...
Newborn screening (NBS) for inborn errors of metabolism is one the most advanced tools secondary prevention in medicine, as it allows early diagnosis and prompt treatment initiation. The expanded newborn was introduced Italy between 2016 2017 (Law 167/2016; DM 13 October 2016; DPCM 12-1-2017). A total 1,586,578 infants born were screened January December 2020. For this survey, we collected data from 15 Italian laboratories, focusing on metabolic disorders identified by tandem mass...
Inflammatory bowel diseases (IBD) are characterized by an increased risk for venous and arterial thrombosis. Although the pathogenetic mechanisms of this predisposition unclear, a possible role inherited factors thrombosis in determining has been suggested.To evaluate factor V Leiden (G1691A) G20210A prothrombin gene mutations occurrence IBD patients.Forty-seven patients (30 ulcerative colitis 17 Crohn's disease) with positive history (9 at sites 38 sites) were enrolled study. For each...
Hypofibrinolysis has been proposed as a possible mechanism underlying the known risk of thrombosis observed in patients with inflammatory bowel diseases (IBD). Thrombin-activatable fibrinolysis inhibitor (TAFI) is recently described fibrinolysis. Increased TAFI plasma levels are associated for venous thrombosis. The objective was to evaluate and their correlations clinical features acute-phase reactants IBD patients.Eighty-one (47 Crohn's disease 34 ulcerative colitis) 81 sex- age-matched...
Lymphocytic and collagenous colitis are emerging as common findings in subjects undergoing colonoscopy for chronic non-bloody diarrhea (CNBD). Data concerning microscopic (MC) still limited affected by controversial epidemiological evidences. Recent converging lines of evidence suggest that MC correlates a lower risk colorectal neoplasia. Accordingly, we prospectively assessed prevalence multicenter cohort submitted to CNBD, thereby defining whether influences the Consecutive patients with...
Background and Aims:Cancer risk in inflammatory bowel disease [IBD] is still debated. In a prospective, multicentre, nested case-control study, we aimed to characterise incident cases of cancer IBD. The role immunomodulators vs clinical characteristics IBD as factors for was also investigated.
Background: Phenylketonuria (PKU) is an autosomal recessive disorder caused by mutations in the phenylalanine hydroxylase (PAH) gene, leading to impaired amino acid metabolism. Early diagnosis through newborn screening (NBS) enables prompt treatment, preventing neurological complications. This study aims describe genetic and phenotypic spectrum of PKU mild hyperphenylalaninemia (m-HPA) patients diagnosed at Department Inborn Errors Metabolism Newborn Screening, Hospital G. Rodolico-S. Marco,...
Summary Background Efficacy of heparin and low‐molecular‐weight heparins (LMWHs) in inflammatory bowel disease (IBD) treatment has been suggested. The multimatrix oral formulation MMX releases active drugs the colon, avoiding systemic absorption. Parnaparin sodium is LMWH chosen to be carried formulation. Aim To assess safety three different dosages (70, 140 210 mg once daily) Parnaparin‐MMX (CB‐01‐05) left‐sided ulcerative colitis (UC). Methods Left‐sided UC patients, with a...
Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and anaemia chronic (ACD). ACD characterized by macrophage retention induced proinflammatory cytokines. Hepcidin the master inducer accumulation during ACD, its production mainly regulated IL-6 novel erythroid hormone erythroferrone (ERFE). This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin levels main regulators, leading to...
Inflammatory and immune mediated disorders are risk factors for arterial venous thromboembolism. bowel diseases (IBD) confer an even greater of thromboembolic events than other inflammatory conditions. It has been shown that IBD patients display defective intestinal barrier functions. Thus, pathogen-associated molecular patterns (PAMPs) coming from the bacterial burden might reach systemic circulation activate innate immunity receptors on endothelial cells platelets, promoting a...
The aim of this study was to investigate the influence IBD5 locus on clinical features inflammatory bowel disease (IBD) patients, and its possible interaction with CARD15 gene.A cohort 1,199 IBD patients (570 CD 629 ulcerative colitis [UC]), 357 healthy subjects were investigated. Information fully available for 855 patients. Two SNPs in (IGR2198a_1 IGR2096a_1) three major variants gene genotyped controls.Homozygous carriers risk alleles significantly more frequent (22.6% IGR2198a_1, OR =...
Background and study aims The thulium laser system (TLS) is an emerging surgical tool. 2-μm wavelength provides a confined coagulation depth (0.2 - 0.4 mm) to reduce the potential for inadvertent injuries. For first time ever, we assessed TLS feasibility endoscopic hemostasis ex vivo in pigs. In addition, performed hemostatic treatments humans. Patients methods Tissue damage induced by using different settings optical fibers was compared that from argon plasma (APC) established animal...
Summary Background: It is controversial whether CARD15 variants are truly associated with a more severe form of Crohn's disease. The relative role genotype and smoking in disease progression also debated. Aim: To investigate the association between history resective surgery patients ileal disease, taking into account as possible confounding factor. Methods: We originally assessed 239 north Italian (mean follow‐up: 10.1 ± 8.1 years). then focused on 193 proven involvement, 70 whom (36.3%)...
Inflammatory bowel diseases (IBD) are characterized by an increased thrombosis risk of uncertain etiology. Coagulation derangement arising from inflammation may be a triggering factor. We hypothesized that strong inhibitors (eg, anti-tumor necrosis factor-α drugs) affect coagulation.Forty patients with IBD were compared 57 control for coagulation factors and endogenous thrombin potential (ETP), the latter being most sensitive marker in vivo pro- anticoagulation balance. measured ETP presence...
Chronic, nonbloody diarrhea may represent a diagnostic challenge in patients with inconclusive findings after standard clinical work-up [1]. In this setting, small-bowel capsule endoscopy (SBCE) has high sensitivity and favorable impact assessing the presence of mucosal lesions suspected Crohn's disease no obstructive symptoms [1] [2] [3].