A5017879870- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Drug Transport and Resistance Mechanisms
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Diet and metabolism studies
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Neuropeptides and Animal Physiology
- Diet, Metabolism, and Disease
- Amino Acid Enzymes and Metabolism
- Inflammatory Bowel Disease
- Vascular Malformations Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Meningioma and schwannoma management
- Soil Carbon and Nitrogen Dynamics
Marche Polytechnic University
2016-2025
Merck Serono (Italy)
2025
ZNA Middelheim Hospital
2024
Ospedali Riuniti di Ancona
2007-2022
Ospedali Riuniti Umberto I
2015-2022
Azienda Ospedaliero Universitaria Ospedali Riuniti
2018-2022
L'organizzazione Ospedale di Civitanova M
2022
Agostino Gemelli University Polyclinic
2018
Saints Cyril and Methodius University of Skopje
2017
University of Palermo
2017
Abstract Background/Aims: High‐fat dietary intake and low physical activity lead to insulin resistance, nonalcoholic fatty liver disease (NAFLD) steatohepatitis (NASH). Recent studies have shown an effect of glucagon‐like peptide‐1 (GLP‐1) on hepatic glucose metabolism, although GLP‐1 receptors (GLP‐1r) not been found in human livers. The aim this study was investigate the presence GLP‐1r exenatide, a analogue, signalling. Methods: expression evaluated biopsies livers high‐fat diet‐treated...
Epithelial-mesenchymal transitions (EMTs) play an important role in tissue construction during embryogenesis, and evidence suggests that this process may also help to remodel some adult tissues after injury. Activation of the hedgehog (Hh) signaling pathway regulates EMT development. This is induced by chronic biliary injury, a condition which has been suggested have role. We evaluated hypothesis Hh promotes bile ductular cells (cholangiocytes). In liver sections from patients with injury...
Nonalcoholic fatty liver disease (NAFLD) may lead to hepatic fibrosis. Dietary habits affect gut microbiota composition, whereas endotoxins produced by Gram-negative bacteria stimulate fibrogenesis. However, the mechanisms of action and potential effect in are still unknown. Thus, we sought analyze whether interfere with Mice fed control (CTRL) or high-fat diet (HFD) were subjected either bile duct ligation (BDL) CCl4 treatment. Previously gut-sterilized mice transplantation oral gavage...
Insulin and insulin–like growth factor (IGF–1) are mitogenic for fibroblasts smooth muscle cells. IGF–1 increases in inflamed fibrotic tissues induces proliferation of rat hepatic stellate cells (HSC). This study evaluates the potential roles these hormones development liver fibrosis. receptor expression was evaluated by immunohistochemistry both cultured human HSC tissue. Phosphorylation 70–kd S6 kinase extracellular–regulated (ERK), cell proliferation, type I collagen gene expression,...
Abstract Stereotactic radiotherapy has two advantages: (a) the possibility of giving high radiation doses to small but spatially well-defined target volumes and (b) presence a stepped dose gradient between volume surrounding healthy tissues. To utilize these advantages, authors built new stereotactic head frame by which intracranial is fixed rotational isocenter 4-MV linear accelerator. The collimator openings are selected according three-dimensional configuration target, based on...
Interferon gamma (IFN-gamma) inhibits in vitro the activation of hepatic stellate cells (HSC), primary extracellular matrix-producing liver fibrosis. This study was undertaken to determine vivo effect IFN-gamma rat model fibrosis induced by dimethylnitrosamine (DMN), where HSC represents an early response cell injury. Rats were killed after 1 or 3 weeks treatment with DMN, IFN-gamma, DMN + saline. Immunohistochemistry used identify proliferating (desmin-positive/bromodeoxyuridine...
Oxidative stress is associated with liver fibrosis and hepatic stellate cell (HSC) activation in vivo. However, it remains controversial whether oxidative contributes to HSC either directly or through a paracrine stimulation by damaged hepatocytes. A medium containing products released from cells undergoing was obtained after incubation of hepatocytes (HCM/Fe) without (HCM) 0.1 mmol/L ferric nitrilotriacetate complex (FeNTA). Exposure HCM/Fe for 24 hours significantly increased the number...
Experimental evidence indicates that reactive oxygen species (ROS) are involved in the development of hepatic fibrosis; they induce stellate cells (HSC) proliferation and collagen synthesis. To address role matrix metalloproteinase (MMP)-2 promoting HSC during injury, we investigated whether oxidative stress modulates growth invasiveness by influencing MMP-2 activation. Cell proliferation, which were studied using Boyden chambers counting under a microscope, evaluated after treatment with...
ABSTRACT A polyphasic approach has been developed to gain knowledge of suitable key indicators for the evaluation environmental impact genetically modified Bt 11 and 176 corn lines on soil ecosystems. We assessed effects (which constitutively expresses insecticidal toxin from Bacillus thuringiensis , encoded by truncated Cry1Ab gene) non-Bt plants their residues rhizospheric bulk eubacterial communities means denaturing gradient gel electrophoresis analyses 16S rRNA genes, nontarget...
Although new treatment modalities changed the global approach to hepatocellular carcinoma (HCC), this disease still represents a medical challenge. Currently, therapeutic stronghold is sorafenib, tyrosine kinase inhibitor (TKI) directed against vascular endothelial growth factor (VEGF) family. Previous observations suggested that polymorphisms of VEGF and its receptor (VEGFR) genes may regulate angiogenesis lymphangiogenesis thus tumour control. The aim our study was evaluate role VEGFR in...
<h3>Objective</h3> Low-grade intestinal inflammation plays a role in the pathophysiology of IBS. In this trial, we aimed at evaluating efficacy and safety mesalazine patients with <h3>Design</h3> We conducted phase 3, multicentre, tertiary setting, randomised, double-blind, placebo-controlled trial Rome III confirmed Patients were randomly assigned to either mesalazine, 800 mg, or placebo, three times daily for 12 weeks, followed additional weeks. The primary endpoint was satisfactory relief...
Abstract: Background /Aims: Reactive oxygen species (ROS) induce HSCs activation, proliferation and collagen gene expression in vitro . Nitric oxide (NO) represents a reactive molecule that reacts with ROS, yielding peroxynitrite. We thus verified the effect of NO on ROS‐induced correlated iNOS ROS formation to activation early phase liver injury leading hepatic fibrosis vivo Methods/Results : were incubated iron ascorbate (FeAsc) , which induced production, ERK1/2 phosphorylation increased...
Ethanol induces liver fibrosis by several means that include, among others, the direct fibrogenic action of acetaldehyde on hepatic stellate cells (HSC). However mechanisms responsible for this effect are not well understood. In communication we investigated signal transduction pathways triggered leading to upregulation α2(I) collagen and fibronectin gene expression in human HSC. Run–on assays showed acetaldehyde–enhanced transcription these 2 genes as early hours, via de novo protein...