A5039877042- Gastrointestinal Bleeding Diagnosis and Treatment
- Inflammatory Bowel Disease
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Diverticular Disease and Complications
- Pharmaceutical studies and practices
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Surgical Treatments
- Healthcare cost, quality, practices
- Iron Metabolism and Disorders
- Autoimmune and Inflammatory Disorders
- Gastroesophageal reflux and treatments
- Erythropoietin and Anemia Treatment
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Liver Disease and Transplantation
- Blood Coagulation and Thrombosis Mechanisms
- Hydrogen's biological and therapeutic effects
- Thyroid and Parathyroid Surgery
- Liver Disease Diagnosis and Treatment
- Climate Change and Health Impacts
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2012-2025
Ospedale Maggiore
2022-2024
IRCCS Policlinico San Donato
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022
Ospedale San Donato
2020
Fondazione IRCCS Istituto Nazionale dei Tumori
2016-2017
University of Milan
2007-2016
Sociedad Española de Endoscopia Digestiva
2015
Bowel ultrasonography (BUS) is a noninvasive tool for evaluating bowel activity in Crohn's disease (CD) patients. Aim of our multicenter study was to assess whether BUS helps monitor intestinal improvement/resolution following different biological therapies.Adult CD patients were prospectively enrolled at 16 sites Italy. Changes parameters [i.e. wall thickening (BWT), lesion length, echo pattern, blood flow changes and transmural healing (TH: normalization all parameters)] analyzed baseline...
In this STARDUST substudy, the effect of ustekinumab on transmural bowel inflammation was assessed in adults with moderate-to-severe Crohn's disease (CD) by using intestinal ultrasound (IUS), a noninvasive imaging procedure.STARDUST an international, multicenter, phase 3b, interventional, randomized controlled trial specifically designed to compare treat-to-target and standard-of-care treatment strategies ustekinumab-treated CD patients. most affected segment at baseline IUS used for all...
Portal vein thrombosis (PVT) is frequently observed in cirrhosis and may be a clinically important complication. In vitro assays for endogenous thrombin potential (ETP) demonstrated that plasma has intrinsic resistance to the anticoagulant action of thrombomodulin (TM-R). This study retrospectively explores association TM-R with de novo PVT its clinical impact on cirrhosis.Fifty-three patients were tested ETP-ratio with/without thrombomodulin. Clinical, endoscopic variables, presence/absence...
Abstract Background and study aims Nomenclature descriptions of small bowel (SB) vascular lesions in capsule endoscopy (CE) are scarce the medical literature. They mostly based on reader's opinion thus differ between experts, with a potential negative impact clinical care, teaching research regarding SBCE. Our aim was to better define nomenclature give description most frequent Methods A panel 18 European expert SBCE readers formed during UEGW 2016 meeting. Three experts constructed an...
In the medical literature, nomenclature and descriptions (ND) of small bowel (SB) ulcerative inflammatory (U-I) lesions in capsule endoscopy (CE) are scarce inconsistent. Inter-observer variability interpreting these findings remains a major limitation assessment severity mucosal lesions, which can impact negatively on clinical care, training research SB-CE.
Optimization of bowel preparation for small capsule endoscopy (SBCE) is debated. Guidelines recommend 2 L iso-osmolar polyethylene glycol (PEG) to improve SBCE visibility. We compared the efficacy standard PEG solution with a 1 plus ascorbate (PEG-ASC) preparation, which has already been established large-bowel preparation.
In this study, we investigated the progression of high-grade dysplasia (HGD)/CRC in patients with hereditary colorectal cancer syndromes (HCSS) and concomitant inflammatory bowel diseases (IBDs). We described natural history a series confirmed diagnosis (HCCSs) IBDs who were referred to Hereditary Digestive Tumors Registry at Fondazione IRCCS Istituto Nazionale dei Tumori Milan. Between January 1989 April 2024, among 450 APC-associated polyposis 1050 Lynch syndrome (LS), identified six (five...
Lymphocytic and collagenous colitis are emerging as common findings in subjects undergoing colonoscopy for chronic non-bloody diarrhea (CNBD). Data concerning microscopic (MC) still limited affected by controversial epidemiological evidences. Recent converging lines of evidence suggest that MC correlates a lower risk colorectal neoplasia. Accordingly, we prospectively assessed prevalence multicenter cohort submitted to CNBD, thereby defining whether influences the Consecutive patients with...
Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and anaemia chronic (ACD). ACD characterized by macrophage retention induced proinflammatory cytokines. Hepcidin the master inducer accumulation during ACD, its production mainly regulated IL-6 novel erythroid hormone erythroferrone (ERFE). This study evaluates whether anti-TNF monoclonal antibodies therapy modurates hepcidin levels main regulators, leading to...
Abstract Background A new capsule endoscopy (CE) system featuring two advanced optics for 344°-viewing and a prolonged operative time has been recently developed Crohn’s disease (CD) patients. Hence, we evaluated, the first time, performance of this novel CE add-on value in multi-center real-life setting. Methods Consecutive patients with suspected or established CD received PillCam™ System as supplementary diagnostic work-up focused on small-bowel between June 2017 2018. Technical clinical...
Abstract Data regarding double switching from originator infliximab (IFX) to IFX biosimilars in inflammatory bowel diseases (IBDs) are lacking. The purpose of this study was evaluate the safety and efficacy CT‐P13 subsequently SB2 (double switch) patients with IBD. Patients undergoing IFX‐double switch eight Centers Lombardy (Italy) November 2018 May 2019 were retrospectively analyzed. discontinuation rate, incidence type adverse events (AEs), clinical remission rate recorded. A comparison a...
Abstract Leukocytes are thought to play an important role in the pathogenesis of inflammatory bowel diseases; granulocyte–monocyte adsorptive (GMA) apheresis, extracorporeal technique aimed at removing activated circulating leukocytes from blood, may represent a safe and effective therapeutic tool these patients. The Italian Registry Therapeutic Apheresis performed observational, multicentric study involving 24 Gastroenterology Units. In this study, laboratory data clinical outcomes 230...
Background and study aims The thulium laser system (TLS) is an emerging surgical tool. 2-μm wavelength provides a confined coagulation depth (0.2 - 0.4 mm) to reduce the potential for inadvertent injuries. For first time ever, we assessed TLS feasibility endoscopic hemostasis ex vivo in pigs. In addition, performed hemostatic treatments humans. Patients methods Tissue damage induced by using different settings optical fibers was compared that from argon plasma (APC) established animal...
Background & Aims: Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms with unclear etiology that may show functioning or non-functioning features. Primary tumor localization often requires integrated imaging. The European Tumors Society (ENETS) guidelines proposed wireless-capsule endoscopy (WCE) as possible diagnostic tool for NETs, if intestinal origin is suspected. However, its impact on therapeutic management debated. We aimed to evaluate the yield WCE in detecting...
Abstract This study tested the hypothesis that bowel preparation with mannitol should not affect colonic concentration of H 2 and CH 4 . Therefore, SATISFACTION study, an international, multicenter, randomized, parallel‐group phase II–III investigated this issue. The II dose‐finding part evaluated , O concentrations in 179 patients randomized to treatment 50 g, 100 or 150 g mannitol. Phase III compared presence intestinal gases 680 (1:1) receive single dose a standard split‐dose L...
Inflammatory bowel diseases (IBD) are characterized by an increased thrombosis risk of uncertain etiology. Coagulation derangement arising from inflammation may be a triggering factor. We hypothesized that strong inhibitors (eg, anti-tumor necrosis factor-α drugs) affect coagulation.Forty patients with IBD were compared 57 control for coagulation factors and endogenous thrombin potential (ETP), the latter being most sensitive marker in vivo pro- anticoagulation balance. measured ETP presence...