Giuseppe Costantino

ORCID: 0000-0003-4369-4252
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About
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Research Areas
  • Inflammatory Bowel Disease
  • Microscopic Colitis
  • Child and Adolescent Psychosocial and Emotional Development
  • Counseling Practices and Supervision
  • Psychological Testing and Assessment
  • Helicobacter pylori-related gastroenterology studies
  • Migration, Health and Trauma
  • Biosimilars and Bioanalytical Methods
  • Heart Rate Variability and Autonomic Control
  • Mental Health Treatment and Access
  • Eosinophilic Esophagitis
  • Liver Diseases and Immunity
  • Health Systems, Economic Evaluations, Quality of Life
  • Educational and Psychological Assessments
  • Resilience and Mental Health
  • Cultural Competency in Health Care
  • Cardiac Health and Mental Health
  • Probiotics and Fermented Foods
  • Celiac Disease Research and Management
  • Dialysis and Renal Disease Management
  • Child Therapy and Development
  • Psychotherapy Techniques and Applications
  • Cardiovascular and exercise physiology
  • Cytomegalovirus and herpesvirus research
  • Behavioral and Psychological Studies

University of Messina
2015-2025

University of Bari Aldo Moro
2020-2024

University of Palermo
2017-2023

Université Gustave Eiffel
2023

Institut des Sciences de la Terre
2023

Université Savoie Mont Blanc
2023

Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2015-2021

Istituti di Ricovero e Cura a Carattere Scientifico
2017

MultiMedica
2013-2017

Medica (Italy)
2016

The authors sought to determine whether integrated mental health services or enhanced referral specialty clinics results in greater engagement health/substance abuse by older primary care patients.This multisite randomized trial included 10 sites consisting of and clinics. Primary patients 65 years old (N=24,930) were screened. final study group consisted 2,022 (mean age=73.5 years; 26% female; 48% ethnic minority) with depression (N=1,390), anxiety (N=70), at-risk alcohol use (N=414), dual...

10.1176/appi.ajp.161.8.1455 article EN American Journal of Psychiatry 2004-07-30

Aims Heart failure ( HF ) pathophysiology is believed to be mediated by autonomic dysfunction, including chronic sympathoexcitation and diminished baroreflex sensitivity, which correlate with mortality risk. Baroreflex activation therapy BAT a device‐based treatment providing through electrical stimulation of the carotid sinus. chronically reduces sympathetic activity in resistant hypertension. The purpose this investigation determine effects clinical . Methods results In single‐centre,...

10.1002/ejhf.138 article EN cc-by-nc-nd European Journal of Heart Failure 2014-07-28

Pain is a major health problem in end-stage renal disease (ESRD) affecting half of the dialysis patients; most them experience moderate to severe degree pain. Nevertheless, impact chronic pain and its consequences are often underestimated. Sources related uremic environment bone (osteitis fibrosa cystica, amyloidosis, osteomalacia), osteoarthritis, calcific arteriolopathy peripheral neuropathy. Moreover, comorbid conditions such as ischemic artery disease, diabetic neuropathy, osteopenia/...

10.5414/cnx77s104 article EN Clinical Nephrology 2012-12-13

Bowel ultrasonography (BUS) is a noninvasive tool for evaluating bowel activity in Crohn's disease (CD) patients. Aim of our multicenter study was to assess whether BUS helps monitor intestinal improvement/resolution following different biological therapies.Adult CD patients were prospectively enrolled at 16 sites Italy. Changes parameters [i.e. wall thickening (BWT), lesion length, echo pattern, blood flow changes and transmural healing (TH: normalization all parameters)] analyzed baseline...

10.1016/j.cgh.2021.03.030 article EN cc-by-nc-nd Clinical Gastroenterology and Hepatology 2021-03-26

The strength of this study lies in the microbiological characterization a wide range farm management data to achieve more comprehensive framework Apulian milk. Specific regional pedoclimatic and conditions impact taxa present their abundances within ecological food niche. obtained results lay groundwork for comparison with other worldwide extensive farming areas.

10.1128/spectrum.00514-22 article EN cc-by Microbiology Spectrum 2022-08-16

Abstract Examined treatment effects with Hispanic children and adolescents using a culturally sensitive storytelling intervention. Inner-city 9- 13-year-olds (N = 90) were screened for symptomatc7bgy by structured interview, randomly assigned to an 8-week intervention or attention-control group, pre- posttested standardized instruments measuring anxiety, depression, phobic symptomatology school conduct. No differences in depression found. Differences favor of found on the remaining outcomes,...

10.1207/s15374424jccp2301_3 article EN Journal of Clinical Child Psychology 1994-03-01

Recognition of cultural distance between Hispanic clients and non-Hispanic therapists has prompted efforts to introduce culture into therapy, but there is little evidence that such influence treatment outcomes. This article evaluates outcomes from a program research on modeling therapy with Puerto Ricans, targeting anxiety symptoms, acting-out behavior, self-concept problems. Evaluation confirmed the impact culturally sensitive symptoms other selected target behaviors, negative effects also...

10.1037//0022-006x.58.6.704 article EN Journal of Consulting and Clinical Psychology 1990-01-01

Research on bilingual patients is equivocal about how language influences clinical judgment in psychiatric interviews. In this study, 148 Hispanics with schizophrenia, depression, and anxiety disorders were interviewed English, Spanish, or both. Hispanic clinicians rated symptoms more severe than did Anglo clinicians, severity was highest interviews, followed by lowest English. Results have implications for Diagnostic Statistical Manual of Mental Disorders (4th edition; American Psychiatric...

10.1037/1040-3590.10.2.120 article EN Psychological Assessment 1998-06-01

To describe the design of Primary Care Research in Substance Abuse and Mental Health for Elderly (PRISM-E) study baseline characteristics randomized primary care patients with mental health problems at-risk alcohol use.Adults aged 65 older were screened at clinics from 10 sites throughout United States. Those diagnosed depression, anxiety, and/or consumption to either integrated or enhanced referral care.Of 23,828 participants, 14% had a positive assessment depressive anxiety disorders, 6%...

10.1177/0898264303260390 article EN Journal of Aging and Health 2004-02-01

Background and aims: Thiopurines represent the mainstay of immunosuppressive therapy in inflammatory bowel diseases. Since it is likely that response to adverse events depends on genetic background patients our study aimed evaluate retrospectively safety a mixed IBD population Southern Europe. Methods: We evaluated demographic clinical data treated with thiopurines. after 6 months responders non-responders therapy. Moreover likelihood remain thiopurine monotherapy was responders, whereas...

10.1016/j.crohns.2011.11.007 article EN Journal of Crohn s and Colitis 2011-12-11

Baroreflex activation therapy (BAT) has recently been shown to reduce muscle sympathetic nerve activity and hospitalization rate while improving clinical variables through 6 months of in patients with heart failure reduced ejection fraction (HFrEF). The objective the present study is extend information on this patient cohort over a long-term follow-up.Eleven were enrolled presented optimized, stable medical therapy, New York Heart Association Class III HFrEF left ventricular 40% or less,...

10.1097/hjh.0000000000000603 article EN Journal of Hypertension 2015-07-02

Background Efficacy and safety of ustekinumab for the treatment ulcerative colitis (UC) has been demonstrated in clinical trials, but few real-world data are available so far. The aim this study was to assess effectiveness a cohort refractory UC patients.Methods Data patients with moderate severe treated were retrospectively collected. Primary endpoint steroid-free remission at weeks 24 52 therapy. Secondary endpoints response, endoscopic remission, persistence 12 months safety.Results A...

10.1080/14712598.2021.1981855 article EN Expert Opinion on Biological Therapy 2021-09-15

Loss of epithelial barrier integrity is considered an early step in the pathogenesis Crohn's disease (CD), and rate enterocyte apoptosis one determinants intestinal function.Tumor necrosis factor-α (TNF-α), major proinflammatory mediators CD, extrinsic signals which initiate enterocytes.The aim this study was to investigate effects experimental colitis on apoptosis, two anti-TNF treatments, infliximab (IFX) etanercept (ETC).In addition, importance receptor I for TNF tested TNFR-1...

10.7150/ijms.5.169 article EN cc-by-nc International Journal of Medical Sciences 2008-01-01

nificant difference was found between UC patients and control group (P > 0.05).In CD patients, no significant association with G908R variant found.L1007finsC SNP showed an (9.8%) compared controls (2.9%, P = 0.002) (2.3%, 0.01).Moreover, in L1007finsC mutations were significantly associated different phenotypes to wild-type patients.No of IBD the TLR4 SNPs either cohort (allele frequencies: D299G-controls 3.9%, 3.7%, 3.4%, 0.05; T399I-controls 2.9%, 3.0%, 0.05). CONCLUSION:These findings...

10.3748/wjg.14.4454 article EN cc-by-nc World Journal of Gastroenterology 2008-01-01
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