A5022473427- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Autoimmune and Inflammatory Disorders
- Gastrointestinal motility and disorders
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Cell Adhesion Molecules Research
- Esophageal and GI Pathology
- Abdominal vascular conditions and treatments
- Immune Response and Inflammation
- Diagnosis and treatment of tuberculosis
- Celiac Disease Research and Management
- Gut microbiota and health
- Liver Diseases and Immunity
- Liver Disease and Transplantation
- Acute Lymphoblastic Leukemia research
- Diet, Metabolism, and Disease
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Medical and Biological Ozone Research
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
Hospital Quirón Teknon
2012-2024
Sonova (Switzerland)
2022
University of Michigan
2017-2021
Hospital Clínic de Barcelona
2006-2019
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2004-2016
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2008-2016
Universitat de Barcelona
2001-2014
Agaplesion Markus Hospital
2012
Centro de Investigación Biomédica en Red
2006-2011
Instituto de Salud Carlos III
2009
This paper is the first in a series of two publications relating to European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on diagnosis management disease concerns methodology process, classification, medical active quiescent disease. Surgical as well special situations including perianal this ECCO Consensus are covered subsequent second [Gionchetti et al JCC 2016].
### 5.1 General When deciding the appropriate treatment strategy for active ulcerative colitis one should consider activity, distribution (proctitis, left-sided, extensive1), and pattern of disease. The disease includes relapse frequency, course disease, response to previous medications, side-effect profile medication extra-intestinal manifestations. age at onset duration may also be important factors. #### 5.1.1 Disease activity The principal activity scoring systems used in clinical...
<h3>Objective</h3> Through genome-wide association scans and meta-analyses thereof, over 70 genetic loci (Crohn9s disease (CD) single nucleotide polymorphisms (SNPs)) are significantly associated with CD. We aimed to investigate the influence of CD-SNPs basic patient characteristics on CD clinical course, develop statistical models predict course. <h3>Design</h3> This retrospective study included 1528 patients more than 10 years follow-up from eight European referral hospitals. outcomes...
Previous studies indicate that ischemic preconditioning protects against lung injury resulting from hepatic ischemia–reperfusion (I/R) through inhibition of tumor necrosis factor (TNF) release Kupffer cells. The present study investigated whether this effect is limited to the or a generalized systemic response and explores molecular mechanisms involved. Hepatic I/R led an increase in neutrophil accumulation liver, lung, splanchnic organs. Although did not modify infiltration liver during...
In Brief Objective: To study the predictive value of Nod2/CARD15 gene variants along with disease phenotypic characteristics for requirement initial surgery and surgical recurrence in Crohn's (CD). Summary Background Data: play an important role susceptibility to CD. Studies genotype-phenotype relationship suggest that these are associated development intestinal strictures. Preliminary reports analyzing association between need have produced inconsistent results. Methods: A total 170 CD...
Abstract Platelets, in addition to exerting hemostatic activity, contribute immunity and inflammation. The recent report that platelets express CD40 led us hypothesize ligand (CD40L)-positive T cells could bind platelets, cause their activation, trigger granular RANTES release, creating a cell recruitment feedback loop. Platelets were cocultured with resting or activated autologous activation was assessed by P-selectin expression. binding endothelial confocal microscopy, its biological...
Abstract Oxidant stress has been implicated in the pathogenesis of inflammatory bowel disease. Antioxidant enzymes, such as superoxide dismutase (SOD), are candidate drugs for modulating this pathogenic factor. This study was designed to determine therapeutic value SOD an experimental model colitis and mechanisms underlying its effects on intestinal inflammation. For that purpose, colitic (trinitrobenzene sulfonic acid-induced) control rats were studied. Groups animals treated with different...
<h3>Objective</h3> Inflammatory bowel diseases (IBDs) feature multiple cellular stress responses, including endoplasmic reticulum (ER) unfolded protein responses (UPRs). UPRs represent autoregulatory pathways that adjust organelle capacity to demand. A similar mechanism, mitochondrial UPR (mtUPR), has been described for mitochondria. ER in intestinal epithelial cells (IECs) contributes the development of inflammation, and since alterations dysfunction are implicated pathogenesis IBDs,...
Background. There is a lack of prospective studies evaluating the natural history colonic ischaemia (CI). We performed such study to evaluate clinical presentation, outcome, and mortality as well variables associated with poor prognosis. Methods. An open, prospective, multicentre was conducted in 24 Spanish hospitals serving population 3.5 million people. The included only patients who met criteria for definitive or probable CI. A website (www.colitisisquemica.org) provided logistical...
Abstract Background Inflammatory bowel diseases (IBD), including Crohn disease (CD) and ulcerative colitis (UC), are complex disorders with multiple comorbidities. We conducted international patient physician surveys to evaluate current experiences perceptions of patients CD or UC physicians who treat IBD. Methods The IBD Global Assessment Patient Physician Unmet Need Surveys comprised a survey survey, fielded in North America Europe between August 16, 2019, November 10, 2019. Adults...
Abstract The CD40/CD40 ligand (CD40L) pathway is involved in Crohn’s disease (CD) pathogenesis. In the patients’ circulation, soluble CD40L (sCD40L) levels are elevated and surface increased platelets T cells, whereas intestine CD40 overexpressed microvasculature cells. therapeutic effects of infliximab CD attributed to its systemic anti-TNF-α action, but because TNF-α modulates both CD40L, we investigated whether affects CD40/CD40L intestine. Eighteen patients were evaluated before after...
Increased homocysteine contributes to the pathophysiology of several chronic inflammatory diseases. Whether could participate in mucosal inflammation bowel disease (IBD) has not been explored yet. Our aims were study levels plasma and IBD patients assess whether can trigger an reaction on human intestinal microvascular endothelial cells (HIMECs).Homocysteine was measured plasma, biopsy, lamina propria mononuclear cell (LPMC) supernatants from normal subjects. HIMEC cultured presence...
Endothelial protein C receptor (EPCR) and thrombomodulin (TM) are expressed at high levels in the resting microvasculature convert (PC) into its activated form, which is a potent anticoagulant antiinflammatory molecule. Here we provide evidence that Crohn disease (CD) ulcerative colitis (UC), 2 major forms of inflammatory bowel (IBD), there was loss expression endothelial EPCR TM, turns caused impairment PC activation by inflamed mucosal microvasculature. In isolated human intestinal cells,...