A5006821996- Gut microbiota and health
- Endoplasmic Reticulum Stress and Disease
- Helicobacter pylori-related gastroenterology studies
- Diet and metabolism studies
- Digestive system and related health
- Inflammatory Bowel Disease
- Systemic Lupus Erythematosus Research
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Rheumatoid Arthritis Research and Therapies
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Diabetes Treatment and Management
- Sarcoidosis and Beryllium Toxicity Research
- Monoclonal and Polyclonal Antibodies Research
- RNA regulation and disease
- Liver Disease Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- 3D Printing in Biomedical Research
- Clostridium difficile and Clostridium perfringens research
- Cancer Research and Treatments
- Systemic Sclerosis and Related Diseases
- Immune Cell Function and Interaction
- Microscopic Colitis
Technical University of Munich
2012-2024
Hanusch Hospital
2015-2024
Massachusetts Institute of Technology
2024
University of Manchester
2024
Digital Research Alliance of Canada
2021
Psoriasis Association
2021
Bipar
2018
Ludwig Boltzmann Institute of Osteology
2015-2017
Leibniz-Institute for Food Systems Biology at the Technical University of Munich
2015
Medical University of Vienna
2009-2013
As the gut microbiota contributes to metabolic health, it is important determine specific diet-microbiota interactions that influence host metabolism. Bile acids and dietary fat source can alter phenotypes of diet-induced obesity, but interplay with intestinal microorganisms unclear. Here, we investigated consequences diets enriched in primary bile or without addition lard palm oil, studied structure functions mice. In combination acids, fed male C57BL/6N mice for a period 8 weeks enhanced...
Abstract Control of intestinal epithelial stemness is crucial for tissue homeostasis. Disturbances in function are implicated inflammatory and neoplastic diseases the gastrointestinal tract. Here we report that mitochondrial plays a critical role maintaining Using cell (IEC)-specific mouse models, show loss HSP60, chaperone, activates unfolded protein response (MT-UPR) results dysfunction. HSP60-deficient crypts display proliferation, accompanied by release WNT10A RSPO1. Sporadic failure...
Objective Reduced Paneth cell (PC) numbers are observed in inflammatory bowel diseases and impaired PC function contributes to the ileal pathogenesis of Crohn’s disease (CD). PCs reside proximity Lgr5 + intestinal stem cells (ISC) mitochondria critical for ISC-renewal differentiation. Here, we characterise ISC appearance under conditions describe role mitochondrial niche-maintenance. Design Ileal tissue samples from patients with CD, mouse models dysfunction (Hsp60 Δ/ΔISC ) CD-like ileitis...
Abstract CD4+CD25+Foxp3+ regulatory T cells (Treg) that specialize in the suppression of immune responses might be critically involved pathogenesis autoimmune diseases. Recent studies have described increased proportions CD4+Foxp3+ lacked expression CD25 systemic lupus erythematosus (SLE) patients but suppressive capacity these has not been analyzed so far. We therefore performed combined phenotypic and functional analyses CD4+CD25−Foxp3+ with diseases healthy controls (HC). Phenotypic...
Objective. To follow-up on all available infliximab-treated SLE patients for safety and long-term efficacy in order to extract information that is useful planning appropriate controlled trials with infliximab SLE. Methods. We analysed charts of six treated an open-label trial seven additional a compassionate care basis uncontrolled organ inflammation. Results. Out nine lupus nephritis, had response after four infusions combination AZA, lasting up 5 years. All five arthritis responded, but...
<h3>Objective</h3> Inflammatory bowel diseases (IBDs) feature multiple cellular stress responses, including endoplasmic reticulum (ER) unfolded protein responses (UPRs). UPRs represent autoregulatory pathways that adjust organelle capacity to demand. A similar mechanism, mitochondrial UPR (mtUPR), has been described for mitochondria. ER in intestinal epithelial cells (IECs) contributes the development of inflammation, and since alterations dysfunction are implicated pathogenesis IBDs,...
Intestinal nutrient transport and sensing are of emerging interest in research on obesity diabetes as drug targets. Appropriate vitro models lacking that allow both, studies processes well subsequent incretin hormone secretion including intracellular signaling. We here demonstrate murine small-intestinal organoids the first model system enabling concurrent investigations transport, fluorescent live-cell imaging signaling processes. By generating organoid cultures from wild type mice animals...
Activating transcription factor 6 (ATF6) regulates endoplasmic reticulum stress. We studied whether ATF6 contributes to the development of colorectal cancer (CRC) using tissue from patients and transgenic mice.We analyzed data 541 with CRC in The Cancer Genome Atlas database for genetic variants aberrant expression levels unfolded protein response genes. Findings were validated a cohort 83 Germany. generated mice intestinal epithelial cell-specific active form Atf6 (nATF6IEC) 2 alleles...
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative proteotoxic stress in mitochondria must be attenuated activation a ubiquitous UPRmt to promote prostate cancer (PCa) growth. Here we show that 2 key components UPRmt, heat shock 60 (HSP60, chaperonin) caseinolytic protease P (ClpP, protease), were required development advanced PCa. HSP60 ClpP expression via c-Myc...
Objectives. The aim of our study was to compare dual-energy CT (DECT) with US for the diagnosis gouty arthritis and correlate imaging findings results from synovial fluid aspiration whenever possible.
Intestinal transport and sensing processes their interconnection to metabolism are relevant pathologies such as malabsorption syndromes, inflammatory diseases, obesity type 2 diabetes. Constituting a highly selective barrier, intestinal epithelial cells absorb, metabolize, release nutrients into the circulation, hence serving gatekeeper of nutrient availability metabolic health for whole organism. Next functions, transporters including peptide transporter 1 (PEPT1) involved in absorption...
Abstract Objective The binding of abatacept (CTLA‐4Ig) to the B7 ligands CD80 and CD86 prevents engagement CD28 on T cells thereby effector cell activation. In addition, a direct effect CTLA‐4Ig antigen‐presenting (APCs) could contribute therapeutic effect. To further elucidate mechanism CTLA‐4Ig, we performed phenotype functional analyses APCs in patients with rheumatoid arthritis (RA) before after initiation therapy. Methods Peripheral blood mononuclear were analyzed at 2 4 weeks...
Mitochondrial dysfunction is associated with inflammatory bowel diseases (IBDs). To understand how microbial-metabolic circuits contribute to intestinal injury, we disrupt mitochondrial function in the epithelium by deleting chaperone, heat shock protein 60 (Hsp60
Background & Aims While hormone secretion from enteroendocrine cells (EECs) and their functions in digestion metabolism are well studied, the role of EECs intestinal inflammation is virtually unknown. In inflammatory bowel diseases (IBD), a contribution to pathogenesis indicated by autoantibodies affecting EEC function general disease symptoms like insulin resistance altered motility. Particularly, L cell-derived glucagon-like peptide 1 (GLP-1) exerts direct effects on intraepithelial...