A5100728518- Dental Radiography and Imaging
- Mitochondrial Function and Pathology
- Endodontics and Root Canal Treatments
- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Endoplasmic Reticulum Stress and Disease
- Heat shock proteins research
- Oral and Maxillofacial Pathology
- Ubiquitin and proteasome pathways
- Prostate Cancer Treatment and Research
- Cell death mechanisms and regulation
- Plant Disease Resistance and Genetics
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Silymarin and Mushroom Poisoning
- Crop Yield and Soil Fertility
- Neuroscience of respiration and sleep
- Dental Trauma and Treatments
- melanin and skin pigmentation
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Amino Acid Enzymes and Metabolism
- Dental materials and restorations
- Essential Oils and Antimicrobial Activity
- ATP Synthase and ATPases Research
Roswell Park Comprehensive Cancer Center
2016-2025
National Institute of Pharmaceutical Education and Research
2024
King George's Medical University
2014-2024
Sankalchand Patel University
2024
All India Institute of Medical Sciences Rishikesh
2024
Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan
2017-2024
All India Institute of Medical Sciences
2024
DR. B.R.A. Institute Rotary Cancer Hospital
2024
Navodaya Dental College and Hospital
2023
Patna Medical College and Hospital
2023
Abstract Cancer cells tend to develop resistance various types of anticancer agents, whether they adopt similar or distinct mechanisms evade cell death in response a broad spectrum cancer therapeutics is not fully defined. Current study concludes that DNA-damaging agents (etoposide and doxorubicin), ER stressor (thapsigargin), histone deacetylase inhibitor (apicidin) target oxidative phosphorylation (OXPHOS) for apoptosis induction, whereas other including staurosporine, taxol, sorafenib...
// Isabel R. Schlaepfer 1,* , Dhanya K. Nambiar 2,3,* Anand Ramteke 2,4,* Rahul Kumar 2 Deepanshi Dhar Chapla Agarwal 2,5 Bryan Bergman 6 Michael Graner 7 Paul Maroni 8 Rana P. Singh 3 Rajesh and Gagan Deep 1 Division of Medical Oncology, Department Medicine, University Colorado Denver, Aurora, Colorado, USA Pharmaceutical Sciences, Skaggs School Pharmacy Cancer Biology Laboratory, Life Jawaharlal Nehru University, New Delhi, India 4 Molecular Biotechnology, Tezpur Tezpur, 5 Center,...
Mitochondrial proteostasis, regulated by the mitochondrial unfolded protein response (UPRmt), is crucial for maintenance of cellular functions and survival. Elevated oxidative proteotoxic stress in mitochondria must be attenuated activation a ubiquitous UPRmt to promote prostate cancer (PCa) growth. Here we show that 2 key components UPRmt, heat shock 60 (HSP60, chaperonin) caseinolytic protease P (ClpP, protease), were required development advanced PCa. HSP60 ClpP expression via c-Myc...
Macrophage migration inhibitory factor (MIF) is responsible for proinflammatory reactions in various infectious and non-infectious diseases. We have investigated the mechanism of anti-inflammatory activity epoxyazadiradione, a limonoid purified from neem (Azadirachta indica) fruits, against MIF. Epoxyazadiradione inhibited tautomerase MIF both human (huMIF) malaria parasites (Plasmodium falciparum (PfMIF) Plasmodium yoelii (PyMIF)) non-competitively reversible fashion (Ki, 2.11–5.23 μm)....
The current study focused on GC-MS analysis for identification of bioactive compounds in leaf extract mangrove plant, Avicennia alba and the was tested cytotoxicity against MCF 7 HeLa cell lines. spectral properties (GC-MS) each separated compound were determined found different namely terpenoids, di-terpene alcohols, tri-terpenes phenolic compounds. proved that contain a high content methanol showed potent Human breastadeno carcinoma (MCF7) lines, viability cancerous cells is reduced to...
This study investigated the direct roles of hydrogen peroxide (H
The mycotoxin, citrinin (CTN), is a contaminant of various food and feed materials. Several in vivo vitro studies have demonstrated that CTN has broad toxicity spectra; however, dermal not known. In the present investigation, exposure to was undertaken study oxidative stress, DNA damage, cell cycle arrest, apoptosis mouse skin. A single topical application caused significant change stress markers, such as lipid peroxidation, protein carbonyl content, glutathione (GSH) antioxidant enzymes...
Hypoxia is associated with aggressive phenotype and poor prognosis in prostate cancer (PCa) patients suggesting that PCa growth progression could be controlled via targeting hypoxia-induced signaling biological effects. Here, we analyzed silibinin (a natural flavonoid) efficacy to target cell growth, angiogenesis, metabolic changes human PCa, LNCaP, 22Rv1 cells under hypoxic condition. Silibinin treatment inhibited the proliferation, clonogenicity, endothelial tube formation by (1% O2 )...
Abstract Prostate cancer (PCa) is the leading malignancy among men. Importantly, this disease mostly diagnosed at early stages offering a unique chemoprevention opportunity. Therefore, there an urgent need to identify and target signaling molecules with higher expression/activity in prostate tumors play critical role PCa growth progression. Here we report that NADPH oxidase (NOX) expression directly associated progression TRAMP mice, suggesting NOX as potential controlling PCa. Accordingly,...
In the present study, phytochemical and antimicrobial analysis of selected mangrove species: Suaeda nudiflora, Lumnitzera racemosa, Ipomoea tuba Avicennia alba was performed. The phenol found in all mangroves tannins terpenoids Avicenia alba. steroids emodins were not species. antioxidant proved that maximum inhibitory potential leaf extract obtained racemosa minimum scavenging activity nudiflora. with different solvents screened for antibacterial against pathogenic strains: Micrococcus...
Interleukin-8 (IL-8) and heat shock protein 60 (Hsp60) play crucial roles in cell survival maintenance of cellular homoeostasis. However, cross talks between these two proteins are not defined.IL-8 expression tumour tissue sections was analysed by immunohistochemistry. IL-8 release cancer cells quantified using enzyme-linked immunosorbent assay (ELISA). Apoptosis caspase activity Annexin-V/PI staining.We observed from response to histone deacetylase inhibitor, apicidin (Api), non-competitive...
Background: Patients with cancer are at a higher risk of severe forms coronavirus disease 2019 (COVID-19) and mortality. Therefore, widespread COVID-19 vaccination is required to attain herd immunity. Objectives: We aimed evaluate the uptake vaccine in Indian patients collect information regarding hesitancy factors that contributed hesitancy. Materials Methods: This was questionnaire-based survey conducted between May 7, 2021 June 10, aged 45 years over, solid tumors. The primary end points...
During the past two decades, significant advances have been made in discovery and development of targeted inhibitors aimed at improving survival rates cancer patients. Among multitude potential therapeutic targets identified thus far, Receptor Tyrosine Kinases (RTKs) are particular importance. Dysregulation RTKs has implicated numerous human diseases, particularly cancer, where aberrant signaling pathways contribute to disease progression. a profound impact on intra intercellular...